Surface display is for more than just antibodies.
It's a powerful platform for engineering enzymes and receptors, too. The key is converting function—catalysis or signaling—into a fluorescent signal.
Strategies here https://t.co/2cqE8Q0oc1
Is your library secretly biased? A few "jackpot" clones can kill your entire screen.
Sanger misses this. NGS catches it.
Our new guide shows how to properly QC your library's uniformity before you waste time and resources.
Read it here: https://t.co/vjfoQ8Nsjm
In surface display, the brightest cell isn't always the best binder. 🤫
Learn how to:
✅ Normalize binding vs. expression
✅ Apply pressure with antigen titration
✅ Select for off-rate & specificity
Level up your flow cytometry game. Read the guide: https://t.co/iQTuVZyjzT
Getting reliable affinity data from your cell display experiments is crucial. Don't let avidity effects skew your results!
Here is how to correctly titrate display levels in yeast and mammalian systems to ensure you're measuring true affinity.
https://t.co/DcqtOgM1Pr
A common misconception about cell display is that it can't handle complex proteins that need proper eukaryotic post-translational modifications. Think again.
Our new technical guide highlights cell display tech https://t.co/RgDu5T8kB5
Protein fitness landscapes are powerful conceptual maps that show how a protein's amino acid sequence relates to its functional ability. They're important because they provide a roadmap for understanding and engineering biology.
https://t.co/cV9mzw7xiW
Pseudovirus neutralization assays have become a robust way to determine the activity of biologics.
If your team has antibodies that you need functional data for, consider Ranomics pseudovirus neutralization assay.
Request a quote here:https://t.co/DsYGD9o0XL
#Antibodydiscovery
What kind of experiences do you guys have with anti-idiotypic antibodies? Have these made great therapeutics? Are they difficult to work with?
#syntheticbiology#proteinengineering#biologics
Will you be attending the Antibody Engineering & Therapeutics Virtual conference, Dec 14-16th? We're excited to learn all that we can from the speakers and presenters!
"B12 antibody" by NIAID is licensed under CC BY 2.0
#proteinengineering#antibody#conference2020
The team here at Ranomics is truly looking forward to the antibody engineering & therapeutics virtual event starting on Dec 14. There will be countless conversations about synthetic biology and how it relates to protein engineering for therapeutics. #AntibodyEng
Where does your firm sit on the Synthetic Biology Value-Added Chain? We find ourselves in the enabling technologies and products as well as the Enabled products sections.
Find out more about our services: https://t.co/JsZ27H6Qjj
#syntheticbiology#DNAsynthesis#Valueadd
As a scientific community, we must translate genetic understandings to people who need it most. VUS's leave physicians and patients unsure. Ranomics is well-positioned to make this apart of our history.
Learn more about our collaboration with BGI here:
https://t.co/djTCQzyyVt
Assay design can be difficult. At Ranomics we specialize in high-throughput assay design to help scientist get their research to market faster and with confidence in their data.
Find out more: https://t.co/zud5ZhWNuL
#syntheticbiology#assaydevelopment#Research#protein
The synthetic biology community is growing as researchers and industry are starting to see the potential of these technologies. To learn more about the #syntheticbiology solutions we offer at Ranomics visit our website: https://t.co/JsZ27H6Qjj
#Biotechnology#synbio#research
Are you familiar with the types of directed mutations that can be done on a DNA molecule? In your opinion, which of these types of mutations is likely to generate the highest number of variants?
#biotech#genetherapy#synbio#syntheticbiology