Lactic acidosis with NRTIs
🎯Commonly implicated NRTIs:
▪️Zidovudine
▪️Lamivudine
▪️Stavudine
▪️Didanosine
🟡Hepatic steatosis:
📍 Lactic acidosis is a contributing factor for hepatic steatosis which often co-exists
📍 Lactic acidosis decreases mitochondria beta-oxidation of fatty acids: TG esters accumulate in liver resulting in hepatic steatosis