REQUITE

Clinical research: Validating Predictive Models and Biomarkers of Radiotherapy Toxicity to Reduce Side-Effects and Improve Quality of Life in Cancer Survivors

[Sara Gutiérrez-Enríquez @SaraGutierrezEn]

Thanks to patient-derived samples from @RequiteProject, we are going to investigate if #microRNAs from blood are #biomarkers of long-term-side effects of #radiotherapy in #breastcancer and #prostatecancer patients!

[Miguel Elías @mikeeelias]

"The Green Journal has just published an exciting new article describing the REQUITE project, from idea to present status." https://t.co/gNooELz2WA

[Marianne Aznar @marianneaznar]

@CatharineWest3 from @RRR_UoM illustrating risk modelling integrating polygenic risk scores with clinical / dosimetric NTCP data. Large international efforts such as @RequiteProject are essential. #medphys #radonc #ptcog58

[Vall d’Hebron Institute of Oncology (VHIO) @VHIO]

Collecting data from 4438 #Cancer patients, the @RequiteProject aims to identify biomarkers for radiotherapy toxicity to improve quality of life.

VHIO's involvement led by @SaraGutierrezEn and Radiation Oncology Department from @vallhebron.

Read more: https://t.co/cV09ZVZUm0

[Sara Gutiérrez-Enríquez @SaraGutierrezEn]

Very happy to have contributed with @VHIO @vallhebron to @RequiteProject, #Europeanproject recruiting data, DNA and RNA samples from about 4300 #breastcancer #ProstateCancer #lungcancer patients to validate prediction models and biomarkers of radiotherapy-induced side effects

[Catharine West @CatharineWest3]

Chris Talbot talking about how circadium rythmn genetic variants affect risk of toxicity when radiotherapy is given am or pm.

[Research at Leicester's Hospitals @LeicResearch]

Were you involved in the #REQUITE study on radiotherapy @Leic_hospital? A new patient leaflet to say thanks & update you on the progress of the study is available here, in 7 languages https://t.co/J1KwxtMUYT
@RequiteProject @hopeagnstcancer

[REQUITE @RequiteProject]

Final REQUITE Dissemination report available! The aim of this report is to provide a final update on the outputs and dissemination activities of the REQUITE consortium. Thanks to the whole consortium including a very active #PatientAdvisoryGroup. see https://t.co/gI3ucXv8Me

[REQUITE @RequiteProject]

REQUITE Report on SNP selection online! To report on the genotyping undertaken of blood samples collected in the observational study and processed by the CIGMR biobank. see:https://t.co/P7CekJvjJg #SNPs #CNVs #RadiotherapyToxicity #PredictionModels.

[REQUITE @RequiteProject]

REQUITE report on patient recruitment available online: https://t.co/wWrw3mLBon In total, 4,438 patients with breast, prostate or lung cancer were recruited prospectively. 383 additional lung cancer patients were genotyped alongside the REQUITE cohorts. (additional lung cohorts)

[REQUITE @RequiteProject]

Chamberlain Mbah defended his PhD and had the manuscript accepted (September 2018): “Challenges in predicting normal tissue toxicity in radiotherapy”. https://t.co/cIjPWtbAVZ

[REQUITE @RequiteProject]

We are very proud of Four PhD students who have successfully defended their theses that made use of REQUITE data: see: https://t.co/UMUGLoa6wC
Gilles Defraene, Tim Rattay, Kerstie Johnson and Chamberlain Mbah.

[REQUITE @RequiteProject]

Kerstie Johnson defended her PhD and the manuscript accepted (July 2018): “Predicting radiotherapy toxicity in patients treated with radical radiotherapy using predictive assays and circadian rhythm”. https://t.co/e7DzofwE54

[REQUITE @RequiteProject]

Tim Rattay defended his PhD and had the manuscript accepted (Febr2018): “Predicting acute radiation toxicity in breast cancer”. This thesis is not currently available. due to an embargo by the REQUITEconsortium that core publications are prioritised above other research/analyses.

[REQUITE @RequiteProject]

Gilles Defraene defended his PhD and had the manuscript accepted (January 2018): “Image based quantification of radiation induced lung damage”. https://t.co/omHpsixaIh

[Manchester Cancer Research Centre @MCRCnews]

❗APPLICATIONS FOR PHD PROJECTS ARE NOW OPEN❗ https://t.co/1nZFndxXK8
We have a wide range of clinical and non clinical opportunities that will train the science leaders of the future!

[Catharine West @CatharineWest3]

@RequiteProject animations highlight a #bettertogether approach to science and how to build cohorts to identify genetic variants that increase risk of radiotherapy toxicity. https://t.co/NhXKrJ5RGZ
https://t.co/k651Pdf1qw

[REQUITE @RequiteProject]

The REQUITE Animation produced @VincentdeMees shows why we founded the @RequiteProject and is available in 6 languages @YouTube: see links on https://t.co/fUELNvVoO5 #ProstateCancer #Breastcancer #Lungcancer #radiotherapy #toxicity #PersonalTreatment

[RT Answers @RTAnswers_org]

Radiation Therapy after surgery can decrease the chance of cancer returning in the breast and improve survival. Check out our video on Radiation Therapy for #BreastCancer to learn more about this treatment method. #bcsm #breastcancerawareness #radonc https://t.co/ARlKuJsXVX