River Charles

[Jonathan Zuckerman MD PhD @JZRenalPath]

Wonderful new study from @arkanalabs.bsky.social on the value of MPO IHC in crescentic GN with immune complexes; especially MN. Likely single disease process. May be useful tool to exclude endocarditis related GN in this setting. https://t.co/3IL6SEUrtJ #renalpath #nephrology

[American Society of Pediatric Nephrology @ASPNeph]

The Utility of Myeloperoxidase Immunostaining to Characterize Immune Deposits in Patients with Crescentic Glomerulonephritis
@KIREPORTS
https://t.co/eyDNrjL0ag

[Sanjeev Sethi @SethiRenalPath]

It was a hard sell.
It is now accepted that the likely etiology of DDD & C3GN in older patients is a monoclonal gammopathy. And targeted treatment is treatment of choice.

But back in 2008-2009 no one would buy it. This is the very first report. #NephJC

https://t.co/GNSppIrskm…

[Jonathan Zuckerman MD PhD @JZRenalPath]

Nice example of striped fibrosis which is often attributed to chronic CNI toxicity in kidney transplant biopsies. #renalpath #pathtwitter

[Sanjeev Sethi @SethiRenalPath]

I had no idea at first, then it suddenly hit me.

1. Normal glomeruli,no FSGS
2. Tubules filled with large granules
3. IF negative=not light chain tubulopathy

Chromogranin +++ in tubules

Dx: Neuroendocrine tumor-associated tubulopathy

65-yr, diabetes, HTN, pancreas mass, ⬆️ Cr

[American Journal of Transplantation @amjtransplant]

Congratulations to the surgeons of @MGHSurgery @LVRiella for the groundbreaking achievement https://t.co/O86Om4mQpO.

To stay informed on the advances in xenotransplantation, check AJT's Xenobulletin page - https://t.co/rU02A6PklM

#AJTXenoBulletin #Xenotransplantation

[Leonardo V. Riella @LVRiella]

With tremendous joy, I share that our patient who received a gene-edited pig kidney transplant was discharged home today after removal of his dialysis access. We hope that this is a first step that will bring hope to many patients waiting for a kidney transplant #xenotransplant

[Rachelle Ariele Gietzen, MD @RachGietzen]

Thank you to the Renal Pathology Society for our research awards! And to @arkanalabs for helping us achieve this. Tomorrow I’ll be sharing how we’ve used MPO staining to characterize immune deposits in Crescentic Glomerulonephritis. #USCAP2024 #renalpathology @Renalpathsoc

[Jonathan Zuckerman MD PhD @JZRenalPath]

Hematoxylin body "crescent" in a case of lupus nephritis. #renalpath #pathtwitter #pathx

[Rachelle Ariele Gietzen, MD @RachGietzen]

Time for kidney week with my favorite co-fellow @RiverCharles5. Thanks @arkanalabs for taking us! #ASN23 #ASNKidney #KidneyWk #kidneypathology

[Jonathan Zuckerman MD PhD @JZRenalPath]

Striking example of multinucleated podocytes in a case of cystinosis. EM shows crystalline clefts in podocyte cytoplasm. #renalpath #pathtwitter

[Sanjeev Sethi @SethiRenalPath]

A simple case but I’m always baffled by this finding-
Normal appearing glomerulus with RBCs leaking through & forming RBC casts.

Urine: RBC and RBC casts.

Dx: IgA nephropathy with mild mesangial proliferative features.

Oxford-M1 E0 S0 T0 C0

23 yr old, hematuria & proteinuria

[Kuang-Yu Jen, MD, PhD @KidneyPath]

Long weekend often brings urgent cases. Here is one that was STATed, ended up showing anti-GBM GN. Diffuse crescents (nearly 100%). Linear IgG. #RenalPath

[Jonathan Zuckerman MD PhD @JZRenalPath]

Time zero implantation biopsy with nodular medial hyalinosis of an arteriole. Typically considered a sign of chronic CNI tox. But as illustrated, not always specific. #renalpath #PathTwitter

[ROHIT MEHRA @drmehrarohit]

Great example of the uncommon Prostate cancer with aberrant p63 expression- Important not to over-grade as they are often atrophic looking #prostatecancer #gupath #pathology @PCF_Science @UMichPath #pathresidents

[Gerônimo Jr. @GeronimoJrLapac]

Multiple skin nodules. Dx?
The condition is strongly associated with ________?

#dermpath #pathology

[DavidSusterMD @MdSuster]

What a case!!

Patient presents with abdominal discomfort; whats the diagnosis?

#pathtwitter #GIpath #surgpath #pathology #clinpath #bugs

[Jonathan Zuckerman MD PhD @JZRenalPath]

Young adult with elevated sCr, proteinuria, and uncontrolled HTN. Biopsy with chronic active microangiopathic injury: arteries with mucoid intimal edema, onion skin change and hyalinosis in arterioles, and focal glomeruli with double contours. #renalpath #pathtwitter

[Journal of Brown Hospital Medicine @BrownJHM]

A 50 year old farmer came with fever, cough, night sweats and rash after recently being in Arizona. No improvement despite being on antibiotics. Culture revealed spherules with endospores. What is the diagnosis and treatment? (Images: Medpics, Wikipedia) #IDtwitter #MedTwitter

[Boonyarit Cheunsuchon, MD @roboonya]

Anti-GBM glomerulonephritis in a 60 yo F. Cellular crescent and small fibrinoid necrosis noted in LM. IgG linear staining along GBM by IF. #renalpath #pathtwitter