Manfredini Lab

Prof. Rossella Manfredini's Lab @ UNIMORE. Myeloproliferative Neoplasms | single-cell | mouse models | immunophenotyping | AIRC Mynerva group

[Manfredini Lab @RM_Lab_]

1/Excited to share our latest study on the effect of chromosome 9p duplication in JAK2-mutated Myeloproliferative Neoplasms - now out in
@LeukemiaJnl 🎉
https://t.co/k27CcDUvEb
🧵below:

[Manfredini Lab @RM_Lab_]

We're now at the end of a fantastic #ESHMPN2026 meeting full of fruitful discussions! So grateful to have had the opportunity to present our data on combined MEK+JAK inhibition to target MF and single-cell multiomic analysis to dissect JAKi resistance in MF!
@ESHaematology

[Ruggiero Norfo @RuggieroNorfo]

What a blast! Lots of exciting advances in the CHIP/MPN and in the HSC fields and lots of friends to meet @EHA_Hematology 2025!

[Manfredini Lab @RM_Lab_]

If you're in coffee break, get a glimpse of our discoveries at Behind the Paper https://t.co/Bcmc9Xeisv
Congrats to all the authors who teamed up in this project! 📄🙋🏻‍♂️🙋🏻‍♀️🙋🏻

[Cancer Stem Cell News @cancerscnews]

Chromosome 9p trisomy increases stem cells clonogenic potential and fosters T cell exhaustion in JAK2-mutant myeloproliferative #neoplasms, reports a team at @UNIMORE_univ, including Dr. Chiara Carretta.
https://t.co/l7oXooSMt4

[UNIMORE @UNIMORE_univ]

🔸Una nuova alterazione del DNA, responsabile di una forma neoplasia mieloproliferativa, è stata scoperta da un gruppo di ricercatrici e ricercatori del Centro Interdipartimentale di Cellule Staminali e Medicina Rigenerativa (CIDSTEM) di Unimore.

🔗https://t.co/6o5As1V79a

[Manfredini Lab @RM_Lab_]

11/ This research was primarily conducted at @UNIMORE_univ by @ailuromania, Sandra Parenti, @TheFiendBlood, and @RuggieroNorfo. We also thank our collaborators at @Uni_Insubria and @dmsc_unifi, and a special thanks to @AIRC_it, the main supporter of all our ongoing projects

[Manfredini Lab @RM_Lab_]

1/Excited to share our latest study on the effect of chromosome 9p duplication in JAK2-mutated Myeloproliferative Neoplasms - now out in
@LeukemiaJnl 🎉
https://t.co/k27CcDUvEb
🧵below:

[Manfredini Lab @RM_Lab_]

10/ Overall, we demonstrated a synergistic effect of JAK2 mutation and chr9p duplication in MPNs. This condition results in:
1. Higher CD34+ stemness and clonogenicity due to OCT4+NANOG upregulation
2. The establishment of a PD-1/PD-L1 dependent immunosuppressive phenotype

[Blood Cancers Today @Blood_Cancers]

Blockage of CTLA-4, an immune checkpoint receptor on T cells, appeared to boost the cytotoxic T-cell–mediated immune response against #myelofibrosis cells in human xenografts.

📰 Read more: https://t.co/0gUMXHfv4U

@LaraTavernari @RuggieroNorfo @RM_Lab_ @AjHematology

[Manfredini Lab @RM_Lab_]

@jjkiladjian Viva Verdi!! 🎻🎶

[Manfredini Lab @RM_Lab_]

Congrats @LaraTavernari , @RuggieroNorfo , and @SebastianoRontauroli for leading this fantastic study on exhausted cytotoxic T cells rescue in #myelofibrosis xenografts! Out today, read it in @AjHematology 👉 https://t.co/o0G9ECJ34W

[Manfredini Lab @RM_Lab_]

@rosslevinemd In the recent ESHMPN meeting our poster showed that chr9p duplication in JAK2mut MPN patients results in higher clonogenicity, stemness and immune evasion. Not a p53-related CNV, but still a relevant proof that CNVs definetely play a disease-modifying role 🧩