Robert C. Sharp, Ph.D.

Biomedical scientist with specialization in genetics, immunology, clinical sciences Google Scholar:

[Robert C. Sharp, Ph.D. @RobertCSharpPhd]

This is my first time ever on twitter! Decided to make it my official work twitter, where I will be posting about papers I published or other interesting biomedical sciences articles. Follow me for more information about autoimmunity and other clinical sciences!

[Robert C. Sharp, Ph.D. @RobertCSharpPhd]

Another #preprint our lab published earlier this year about how #vps35 and #lrrk2 play a huge role in #microglia #inflammation. Another good paper about how peripheral immune response could cause #neurodegenerative symptoms: https://t.co/M8N0o5Jgh3

[Robert C. Sharp, Ph.D. @RobertCSharpPhd]

Getting back on X. Here is a #preprint our lab published last year about how peripheral inflammation mediates #Lrrk2 kinase activity by #Rab32 expression. This shows that a peripheral immune response could cause #neurodegenerative symptoms: https://t.co/jnCws8uXTK

[Robert C. Sharp, Ph.D. @RobertCSharpPhd]

I'm guest editing a #specialissue for @FrontImmunol, and we are looking for submissions of papers for our issue: Polyautoimmunity Development with Autoimmune-Associated Gene Mutations (https://t.co/u5OKnHCTMt). Send papers! #polyautoimmunity #autoimmunity #Frontiers #Immunology

[Robert C. Sharp, Ph.D. @RobertCSharpPhd]

I am a guest editor of a #specialissue for @Cells_MDPI , and we are looking for submissions of papers for our issue: Molecular and Cellular Mechanisms of Type 1 Diabetes (T1D) (https://t.co/xJ6s0puw3o)
Please contribute your research! #type1diabetes #T1D #research #Cells #MDPI

[Robert C. Sharp, Ph.D. @RobertCSharpPhd]

Haven't post in awhile! I feel like I'm ready to get back into Twitter/X or whatever you call it now! Going to try to update this more frequently and highlight some cool papers out there in the #immunology field. Also wanting to advertise myself as well too! #backagain #scientist

[Robert C. Sharp, Ph.D. @RobertCSharpPhd]

Our #new #paper on how #flowcytometry methods and results are extremely variable across 58 studies looking at mouse brains. #systematicreview #immunology #mousebrain
Experimental procedures for flow cytometry of wild-type mouse brain: a systematic review https://t.co/8NWn4NmRw8

[Robert C. Sharp, Ph.D. @RobertCSharpPhd]

My old #postdoc #lab doing great work! Proud that I worked with such great people doing great #science to improve #treg functionality to reduce #t1d. #cd226 #diabetes #nodmice #mousestudies #mice #tcells #foxp3 #tcellregulation #molecularbiology
https://t.co/WWr1AxvuRi

[Robert C. Sharp, Ph.D. @RobertCSharpPhd]

Our #preprint of a new #systematic #review based on determining #immunecell counts from #wildtype #mouse #brains via #flowcytometry. The field is #chaotic!
Flow cytometry for immune characterization in homogenized mouse brain: A systematic review https://t.co/YRtqt3rnHl

[Robert C. Sharp, Ph.D. @RobertCSharpPhd]

A #study that shows opposite of what I have talked about in my #research. This group says that #SIRPalpha #SIRPa is NOT found on #pancreatic #betacells, but found on #Tcells. Just shows that the #CD47 #SIRP #signaling is still not fully understood
https://t.co/oP8cBFeebN

[Robert C. Sharp, Ph.D. @RobertCSharpPhd]

A great example of using #CRISPRCas9 #geneediting to show how #riskallele #SNPs can cause overactive #immunecell activity. A good mesh of my old #PhD project and my old #Postdoc project! Wish I had the technology back in the day to do this! #PTPN22 #Tcell
https://t.co/C5FW1jLnT9

[Robert C. Sharp, Ph.D. @RobertCSharpPhd]

Good #review about a specific subset of #diabetes called Latent Autoimmune Diabetes in Adults (#LADA), which doesn't get enough attention in the #autoimmune field. Discussion about different #immuneprofiles of LADA patients compared to both #T1D and #T2D.
https://t.co/vegFwRvVO6

[Robert C. Sharp, Ph.D. @RobertCSharpPhd]

A #variant of #PTPN22 that could negatively regulate active PTPN22 proteins. Relatable to my old #research!
Clinical value of the expression levels of protein tyrosine phosphatase non-receptor type 22.6 mRNA in PBMCs in Crohn’s disease https://t.co/nObtIjonw6

[Robert C. Sharp, Ph.D. @RobertCSharpPhd]

Hello everyone! Finally decided to get back into trying to keep this regular again! To start, here is a really good #protocol on #visualizing #immunecells from live #pancreatic tissues.
https://t.co/j1N2AZGPQr

[Robert C. Sharp, Ph.D. @RobertCSharpPhd]

Back at it again! A really good #review about how the #gutflora and #intestinalhealth is associated with #neurologicaldisorders and #neurologicaldiseases!
#gutmicrobiota #immunity
Mucosal Immunity and the Gut-Microbiota-Brain-Axis in Neuroimmune Disease
https://t.co/Ewu3PTwjCl

[Robert C. Sharp, Ph.D. @RobertCSharpPhd]

Hey everyone! It's been awhile, but my wife and I have been a little busy...a new little #scientist in the making! Also another #UCFKnight in the making as well! I'll be back on #Twitter more later this month to provide great #science #papers!!! #UCF #LetsGoKnights

[Robert C. Sharp, Ph.D. @RobertCSharpPhd]

An interesting #study that looks at #serum levels of #IL1b #NLRP3 and #synuclein from #Parkinsonsdiease patients. The #inflammasome could play a bigger role in #pathogenesis!
Inflammasome and α-synuclein in Parkinson's disease: A cross-sectional... https://t.co/6ddd9b7xGW

[Robert C. Sharp, Ph.D. @RobertCSharpPhd]

A really great #review that is tying the #immunesystem to #neurodegenerative diseases, such as #Parkinsonsdisease together. Very exciting stuff!
Parkinson disease and the immune system — associations, mechanisms and therapeutics
https://t.co/sF1dQHsNtC

[Robert C. Sharp, Ph.D. @RobertCSharpPhd]

This group found some potential new #genetic targets for #type1diabetes that could influence #immune #phenotypes! Good stuff!
A genome-wide functional genomics approach uncovers genetic determinants of immune phenotypes in type 1 diabetes https://t.co/DgBsfHOIeI

[Robert C. Sharp, Ph.D. @RobertCSharpPhd]

More evidence that #HLA isn't the only #susceptibility #gene associated with not only #T1D, but with other #autoimmunedisease as well.
Non-HLA Gene Polymorphisms in the Pathogenesis of Type 1 Diabetes: Phase and Endotype Specific Effects https://t.co/okmnlBczZf

[Robert C. Sharp, Ph.D. @RobertCSharpPhd]

An interesting kind of "rebuttal" to my work as a #phdstudent. This group found that #PTPN2 #SNPs are NOT associated with #CrohnsDisease in #Indian patients. Shows how much #genetic differences there is between different countries when looking at SNPs!
https://t.co/ZVM1AYbsuG