Rob Palumbo

Growth, startups, Tweets etc. | fCMO @ week over week | Growth Partner at | ex-@OutPointHQ, @Borrowell, @ProperlyHomes, @PolicyMeHQ

[Aoden Teo @AodenTeoMT]

Today, we’re excited to introduce Miso One, the most emotive voice model in the world.

Miso One is an 8-billion-parameter text-to-speech model for highly expressive speech generation. It emotes like a human and responds faster than a human, with just 110 milliseconds of latency.

We’ve open-sourced the model weights, with API access coming soon.

Hear how Miso One sounds in the thread below.

[Sean Frank @Seanfrank]

Rapid weight lose and GLP-1s are going to change Americans lives more than ai this decade (before 2030)

[Adrienne LaFrance @AdrienneLaF]

You really have to read Ted Chiang on consciousness and AI—just published in The Atlantic:

https://t.co/z9eRSlkwQ8

[Vikram Pai @vikpai]

Running a business is just realizing how dumb you were 6 months ago every 6 months

[Adam Shuaib @adamshuaib]

Most ultra successful people have a very low need for social approval, although society tends to label this incorrectly as a red flag.

The average person is terrified of looking like a fool or bothering people. I’ve met CEOs that will send ten follow-up emails to a dream hire or pitch their idea to a stranger in an elevator without a second thought. This personality type means they can bypass the politeness instinct that slows down everyone else’s career.

Hesitation to ask for help or feedback is a common bottleneck in most professions; someone who isn't slowed by the fear of being annoying can squeeze a year’s worth of progress into a week.

There are very few things in life that shameless persistence won’t give you.

[Rob Palumbo @RobPalumbo]

@wesbos don’t forget our friend

[Brian Armstrong @brian_armstrong]

Aging is arguably the root cause of most major diseases (loss of function in our cells). Four years ago, we made a bet that aging was treatable, and NewLimit was born.

NewLimit now has a prototype drug that reverses the age of some human cells (restores function they had when they were younger), and a clinical trial scheduled for next year (with more drug candidates in the pipeline).

Grateful to Founders Fund, Thrive, Greenoaks, and the rest of the investors for this latest round. @jacobkimmel and the team are just getting started.

[ClaudeDevs @ClaudeDevs]

How do you get Claude Code to check its own work before handing it back?

Watch how you can encode your manual checks so Claude closes its own feedback loop:

[Dr. Parik Patel, BA, CFA, ACCA Esq. @ParikPatelCFA]

Imagine paying $20/month for Claude when you can just ask questions to the Chipotle customer support bot and get Opus 4.8 for free

[Eric Glyman @eglyman]

Introducing Stack.

The AI operating system that lets accounting firms take on more clients without hiring. Learns your firm's process, runs the close, posts the journals. Fully auditable.

We’re living through the biggest shift in accounting since the spreadsheet.

[Rob Palumbo @RobPalumbo]

LLMs allow CFOs to switch production costs from fixed labour costs (annual salaries) to variable operating costs.

Big P&L and cash flow management implications.

[Sam Blond @samdblond]

3/ There is no one in the world better than you at selling the vision of your product and company. Sales is hard. Keep going. Hopefully the below is helpful.

[Factory @FactoryAI]

Introducing model routing to Factory.

Factory Router picks the right model for every task, automatically.

Maintain frontier performance while cutting costs by 25%.

[Rob Palumbo @RobPalumbo]

Ask: Do I have any friends working in PE or at PE-backed roll-ups focused on food and beverage or pharmaceutical manufacturing?

I’m looking to do a few customer discovery conversations on how LLMs and AI are being adopted on production lines. Not selling. Just trying to better understand current workflows, pain points, and practical AI use cases.

[Rob Palumbo @RobPalumbo]

Ask: Do I have any friends working in PE or at PE-backed roll-ups focused on food and beverage or pharmaceutical manufacturing?

I’m looking to do a few customer discovery conversations on how LLMs and AI are being adopted on production lines. Not selling.

Just trying to better understand current workflows, pain points, and practical AI use cases.

[Peter Kazanjy @Kazanjy]

Founders: The champion enablement kit:

1. 1-page executive summary
2. ROI calculator
3. Implementation timeline
4. Security/tech specs
5. Customer references

Give them everything needed to sell internally.

Make it easy to buy.

[broadglow @broadglow]

I've been saying -- its now a certainty we'll have

- goalseeking autoresearch AI in all major research fields (cs, math, pharma)
- 1000x the autonomous vehicles
- 1m humanoid robots - agentic coding, code review, and debugging (probably still a 10-20x compute build)
- jevons paradox applied to music, film and apps (ai generated songs already printing on Spotify)

these imply a 100x in compute build out and will have massive economic impact

[Samuel Hume @DrSamuelBHume]

One of the most amazing things I’ve ever seen: a standing ovation for the full Daraxonrasib results

I feel inspired and energised, to put it mildly — we have a targeted therapy for pancreatic cancer now, and nothing is undruggable anymore

[wordgrammer @wordgrammer]

Working 100 hours a week is characteristic of jobs where you “work” very little, but need to always be on call (think: investment bankers). Fields that require deep creative work or technical precision usually get 4 productive hours each day. Agents moved SWE from (2) to (1)

[Ilya Sukhar @ilyasu]

Agree. But still find it very disconcerting when founders can't articulate a simple wedge value proposition to attract early adopter customers.