RO TRIAD

*Unofficial* Stylized Dr. Ro triads from 2pm lectures | tweets ≠ medical advice | #Pathology simplified in 1-2-3 | #AtTheScope #pathologists #pathology

[RO TRIAD @RoTriad]

Helpful features in yolk sac tumor: eosinophilia hyaline globules, basement membrane-like material, Schiller-Duval bodies

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Nots of Spermatocytic Tumor: not assoc with ITGCN, not assoc with undescended testis, not seen outside testis

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Spermatocytic Tumor: Small lymphocyte-like cells, large cells with, soccer ball-like chromatin, intermediate cells

[RO TRIAD @RoTriad]

Beware of testis germ cell tumor cells hiding in prominent granulomatous inflammation. OCT3/4 can help highlight them.

[RO TRIAD @RoTriad]

Choriocarcinoma: two cell population (mononuclear/multinucleated giant cell), hemorrhage, spatial arrangement (vague villous configuration)

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Seminoma triad: lymphocytes, fibrous bands, clear cells with no nuclear overlapping #RoTriad

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Seminoma gross appearance: homogenous, lobulated, bulging

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Seminoma cytologic features: distinct cell border, no nuclear overlapping, uniform cells. #RoTriad

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Intratubular germ cell neoplasia: clear cytoplasm, nuclear enlargement, prominent nucleolus. Use OCT3/4 to diff btw ITGCN (+) vs other (-)

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Three types of testes Germ Cell Tumors (continued)

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Three types of testes Germ Cell Tumors #AlwaysThree #RoTriad

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Always remember to do your BeST!

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@davidacohenmd @marenwhymd @JMGardnerMD very good!

[Maren Y. Fuller is not here @marenwhymd]

Dr. Ro: Always do your BeST! 👏🏼👏🏼👏🏼 @RoTriad @JMGardnerMD @davidacohenmd #pathology

[RO TRIAD @RoTriad]

Reporting lymph node metastasis: number of positive nodes, extranodal extension present/absent, size of largest tumor deposit

[David Cohen, MD @davidacohenmd]

Dr Ro and head... MP invasion in UCa @marenwhymd @RoTriad

[RO TRIAD @RoTriad]

Extension of urothelial cancer to prostate: within prostate gland only = T2, with stromal invasion through prostate gland = T4

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A few notes on fat invasion in urothelial carcinoma

[RO TRIAD @RoTriad]

Remember the 2 types of noninvasive carcinoma in bladder: Ta = noninvasive papillary carcinoma, Tis = carcinoma in situ; give low/high grade

[RO TRIAD @RoTriad]

Inverted urothelial papillary lesions: inverted papilloma/PUNLMP, inverted papillary urothelial carcinoma, carcinoma associated w/ papilloma