Ruby Pelingon

Biochemistry | Glycoproteomics | Protein Engineering | Postdoc at UQ | @[email protected]

[Nature Reviews Bioengineering @natrevbioeng]

Engineered cells as programmable mRNA delivery vehicles https://t.co/6uns57HzGM

[Kelvin Anggara @vixklen]

#TeamMassSpec 🫶 #TeamCryoEM! Membrane proteins ions from mass spec = now visualized in 3D! Congrats @ESIBDLab!

https://t.co/ztjAiSU9wL

[Marcin Czerwinski @CzerwinsMarcin]

Everything that you wanted to know about glycomics in clinical science: @PLinkLenczowski presents his first-hand experience about the evaluation of glycans in cancer, autoimmune disorders, inflammation, CDGs, and neurodegenerative diseases. Must-read!

https://t.co/8f7vjaNBO2

[Exosome RNA @ExosomeRNA]

Engineered bacterial extracellular vesicles show promising anti-inflammatory and tissue-repairing effects in IBD. BEVs from L. plantarum may offer a new therapeutic path. - @UofMaryland https://t.co/3y7RtNwpLA

[Iain Wilson 🏴󠁧󠁢󠁳󠁣󠁴󠁿🇦🇹 @IainWil92988866]

Final published version of my student's paper on glycan remodelling and glycan arrays in @jbiolchem
Generating and probing NeuAc, NeuGc, GlcA, SO4 and Fuc epitopes, partly in combination, on N-glycan, lacto-tetraose or ganglioside scaffolds.
#glycotime
https://t.co/4PHjkhGltu

[Prof. Nikolai Slavov @slavov_n]

A beautiful demonstration of individual genes producing multiple proteoforms with different subcellular localizations.

Alternative translation initiation sites generate N-terminally truncated proteoforms that localize to different cellular compartments.

[Science Magazine @ScienceMagazine]

Targeted protein degradation is a therapeutic strategy that entails hijacking a cell’s natural pathways for marking proteins for elimination.

In a new #ScienceReview, researchers look at recent advances that expand the range or targets, drug modalities, and control mechanisms, enabling promising therapeutic applications. https://t.co/UGAxRvSW35

[Nature Reviews Drug Discovery @NatRevDrugDisc]

Chemical modifications can improve the stability, efficiency and specificity of RNA therapeutics, while reducing their immunogenicity - find out more in this review
https://t.co/sEugYpvX26
https://t.co/F8UxINqUMS

[Marcin Czerwinski @CzerwinsMarcin]

Proteoglycan linkage region glycosyltransferases B4GalT7, B3GalT6, B3GlcAT-1 are dimeric and show promiscuity towards complex type N-glycans. B3GalT6 is a covalent dimer linked by a disulfide in the center of the large dimerization domain. https://t.co/EHHOSW4L06
#glycotime

[Nature Reviews Drug Discovery @NatRevDrugDisc]

For readers interested in approaches to improve the preclinical assessment of immunogenicity risk of engineered antibodies and other protein therapeutics, here's a recent review https://t.co/dB3dgDLPx4
https://t.co/wQKwgAelmh

[Nature Reviews Molecular Cell Biology @NatRevMCB]

New Online! N-glycan-dependent protein maturation and quality control in the ER https://t.co/HT9M71bmIK

[Marcin Czerwinski @CzerwinsMarcin]

New review on structural glycobiology in glycosciences: "From enzymes to organelles". Carbohydrate processing enzymes, glycosylation networks in vitro, cryo-ET in direct visualisation of native biology.
https://t.co/IKnwazqj7K

#glycotime

[Prof. Nikolai Slavov @slavov_n]

This rate of validation suggests that antibodies should be considered non-specific until proven otherwise:

357 validated out of 1,124 tested.

.

[Molecular & Cellular Proteomics @molcellprot]

MCP press| Improving the Depth and Reliability of Glycopeptide Identification Using Protein Prospector.
Learn more:
https://t.co/XHbVxFlwVq

[Trends Cell Biology @TrendsCellBio]

Sugar symphony: glycosylation in cancer metabolism and stemness https://t.co/KYusUwlQLt

[Marcin Czerwinski @CzerwinsMarcin]

Interesting piece about glycosylated RNAs (glycoRNAs): sialylated glycoRNAs are present in human cell lines, and sialylation of glycoRNAs depends on the catalytic isoforms of the oligosaccharyltransferase (OST) complex.

https://t.co/DKw2nNEUCW

[Nature Communications @NatureComms]

@SMereiter @penningerlab and colleagues introduce a scalable method to profile N-glycans across 20 mouse tissues, revealing tissue-specific glycosylation patterns and novel N-glycan structures #glycotime

https://t.co/Lgsl6I6TBc

[Nature Reviews Bioengineering @natrevbioeng]

Protein sequencing is key to understanding cellular signalling pathways and metabolic processes. In their Review, @cees_dekker et al discuss how nanopores enable single-molecule protein sequencing and the identification of post-translational modifications
https://t.co/4K22T2ktga

[Shi Yan @mryanshi]

#glycotime Cell-based glycoengineering of extracellular vesicles through precise ... https://t.co/m3sqCtYX2a

[Marcin Czerwinski @CzerwinsMarcin]

Now this is big! S. aureus vaccine exerts production of high levels of IL-10, resulting in the hyper-α2,3 sialylation of antibodies, which interfere with opsonophagocytic killing of S. aureus. Reviewed in https://t.co/YY1jAnXbsI, details in https://t.co/AaNJkuMwYC
#glycotime