@dharshinimaru@Adam_Biotech This is the under-discussed bottleneck. AI can expand the design space quickly, but preclinical assays still decide whether the biology is real. Faster tissue-relevant feedback loops may matter as much as better molecule generation.
@NatureMedicine This framing is important: gait is not one symptom, but a timing-and-circuit problem. Adaptive stimulation that separates freezing, stride timing, and context feels closer to how patients actually fail in daily life.
@NatureMedicine Agree. The next useful differentiation may be less about another few percentage points of weight loss and more about tolerability, persistence, muscle preservation, and what happens after discontinuation. Trial design should make those tradeoffs visible earlier.