S3 Ventures

Born in Texas. Investing Nationwide.

[S3 Ventures @S3ventures]

https://t.co/0EyPgVAxwV

[S3 Ventures @S3ventures]

🎉We're proud to co-lead Advanced NanoTherapies' $31M oversubscribed Series B!

Restenosis after coronary intervention remains one of cardiology's most persistent challenges and outdated therapies often fail to deliver durable results. Advanced NanoTherapies' SirPlux Duo DCB uses a proprietary nanoparticle system to deliver two proven antiproliferative agents directly into the vessel wall, achieving higher potency at lower doses while leaving nothing permanently behind in the vessel.

Exclusively licensed from @ClevelandClinic and FDA Breakthrough Designated, SirPlux Duo has completed a first-in-human study in 28 patients with two-year follow-up showing no new treatment failures. The company is conducting an ongoing 30-patient feasibility study in Spain mirroring the U.S. pivotal protocol.

We're proud to back this exceptional team alongside a strategic co-lead and continued support from T45 Labs and existing investors.

 Full story in the comments👇

 #MedTech #SeriesB #SirPluxDuo #DrugCoatedBalloon #InterventionalCardiology #VascularIntervention

[S3 Ventures @S3ventures]

@AdvancedNanoT

🎉We're proud to co-lead Advanced NanoTherapies' $31M oversubscribed Series B!

Restenosis after coronary intervention remains one of cardiology's most persistent challenges and outdated therapies often fail to deliver durable results. Advanced NanoTherapies' SirPlux Duo DCB uses a proprietary nanoparticle system to deliver two proven antiproliferative agents directly into the vessel wall, achieving higher potency at lower doses while leaving nothing permanently behind in the vessel.

Exclusively licensed from @ClevelandClinic and FDA Breakthrough Designated, SirPlux Duo has completed a first-in-human study in 28 patients with two-year follow-up showing no new treatment failures. The company is conducting an ongoing 30-patient feasibility study in Spain mirroring the U.S. pivotal protocol.

We're proud to back this exceptional team alongside a strategic co-lead and continued support from T45 Labs and existing investors.

 Full story in the comments👇

 #MedTech #SeriesB #SirPluxDuo #DrugCoatedBalloon #InterventionalCardiology #VascularIntervention

[S3 Ventures @S3ventures]

https://t.co/xS0WkLDbDF

[S3 Ventures @S3ventures]

🎉 Having led @ArpioRPO's Seed, we are excited to double down and co-lead their $15M Series A with @Paladincap—alongside @DraperVC, Uncorrelated, @valorvc, CreativeCo Capital, and Lookout Ventures!

Big congrats to Doug Neumann, Shaw Terwilliger, and the entire Arpio team!

Arpio’s cloud resiliency platform enables enterprises to validate and recover critical workloads with unparalleled speed and ease.

Learn more 👉 https://t.co/CEPHuuTser

#CloudResilience #Cybersecurity #DisasterRecovery #AIInfrastructure

[S3 Ventures @S3ventures]

🏥 CEO Spotlight Now Live!

Denis Harrington, President & CEO of @VMG_FLEX, found his way into vascular medicine after graduating from West Point and serving time in the Army. It became his life's work.

With 30+ years in vascular device commercialization, Denis has led organizations of 1,800+ people, guided companies through acquisition, and now leads the team behind the FLEX™ Vessel Prep System — a fundamentally different approach to lesion preparation that is redefining what's possible in endovascular care.

In our latest CEO Spotlight, Denis shares his journey from Army officer to medical device executive, what it means to build technology around a clinician's frustration, and where he sees AI reshaping the future of vascular intervention.

Read the full interview to hear Denis's perspective on mission-driven leadership and the next frontier of medical device innovation.

🔗 https://t.co/XCQl6I44oq

#CEOSpotlight #Leadership #MedTech #VascularHealth #HealthcareInnovation #MedicalDevices

[S3 Ventures @S3ventures]

@MythicInc https://t.co/jzAKixEIgM

[S3 Ventures @S3ventures]

🎉 Congrats to @MythicInc on acquiring Videantis GmbH, one of Europe's leading digital processor IP companies with 25M+ chips shipped worldwide!

This acquisition expands @MythicInc's hybrid #AI compute platform — delivering 100x greater energy efficiency over conventional GPU-based systems.

 Full story in the comments👇

 #AICompute #EdgeAI #DeepTech #Semiconductors

[S3 Ventures @S3ventures]

Last week, we had the privilege of co-hosting some of the most inspiring female founders and CEOs in #AustinTech. From incredible bites to a breathtaking performance 🎶 by Maren Morris at The Moody Theater—this is what community in #Austin looks like.

Thank you to Amee Ly and Eli Kaplan of @justworks, our very own @nicole_a_bentz, and Addie Olsen Rasche of Silverton Partners for hosting — and to all who shared their evening with us: Abby Coleman, Amela Kraja, Ashley Beeler, Carolyn Lowe, Connie Lee, Corina Kellam, Jacqueline Karlin, Jana Montgomery, LaTecia Johnson, Neha Shivnani, Rachel Balke, Sarah Hampton, Stephanie Guttman, Vanessa Heppner

#FemaleFounders #WomenInTech #S3Ventures

[S3 Ventures @S3ventures]

Congratulations to @SuiteStudios_io and the @Adobe - https://t.co/8kbus9D8R1 team on @Frame_io Drive being named a #BestofShow 🏅 award winner at the 2026 @NABShow! 🎉

Read more here 👇
https://t.co/FjeXoHgHHz

[S3 Ventures @S3ventures]

Thank you to all the venture investors who attended our dinner with @LiveOakBank at Raleigh's Michelin award-winning 🥂 Mala Pata Molino + Cocina. 🌮

The founders, startups, and investors in North Carolina continue to impress, which is why we've backed four incredible companies across the state: @allstacks, @repvue, @ArpioRPO, and most recently, @tryopine. We can't wait to see what visionary founders and ideas emerge next from this thriving ecosystem. 🚀

Special thanks to @tweeterwee and Matt Sallese for co-hosting and making this one to remember for all our attendees: Daniel Coley, @davidstjones, Greggory Bordes, Jackie Lipkin, @jcaplain, @mrostick, @M_Bressler, Michael Wooten, Pat Scheper, Sonali Sanjay, Trent Myers, and Yash Mehta

[S3 Ventures @S3ventures]

During #SaaStockUSA on Tuesday @charlieplauche took the stage, breaking down #tech trends every #SaaS investor should have on their radar.

Big thanks to @SaaStock for putting on a great event!

[S3 Ventures @S3ventures]

@SuiteStudios_io @Frame_io @Adobe https://t.co/CG2gCGkZD9

[S3 Ventures @S3ventures]

@SuiteStudios_io file streaming technology is now the engine behind @Frame_io Drive, an @Adobe company, giving creative teams real-time access to media from any location.

This is an infrastructure shift the industry has been waiting for. Congratulations to Craig Hering and the entire @SuiteStudios_io team on this milestone! 🎉

#FrameDrive #FileStreaming #MountedStorage

Read the full story in the comments 👇

[Frame.io @Frame_io]

Say goodbye to lengthy downloads, sync delays, and version chaos.

Frame.‍io Drive removes creative workflow friction.

Mount Frame.‍io directly to your desktop for instant access to media without downloads, syncing folders, or transferring files.

[S3 Ventures @S3ventures]

🎉Congratulations to @rosezhong and the entire @GetSudozi team on their acquisition by Zone & Co!

Rose founded @GetSudozi to solve the challenges she faced firsthand as a 3-time CFO, with finance teams flying blind on spending decisions, until invoices landed on their desks. @GetSudozi was built to move finance into the decision-making process — centralizing purchase requests, automating vendor management, and embedding AI-driven procurement intelligence throughout vendor intake, purchase requests, and approval workflows.

By joining Zone & Co, Sudozi's procurement intelligence will plug directly into the AI-powered financial operations platform already trusted by 4,000+ companies nationwide.

It has been a privilege to be part of @GetSudozi's journey since our initial investment in 2021, and we can't wait for what's next.

Read more here 👉 https://t.co/5KNuTuyBjY

[S3 Ventures @S3ventures]

🎉 Portfolio Announcement: S3 Ventures is thrilled to announce our continued investment in @EndovascularEng (E2), who closed an $80M oversubscribed Series C co-led by @GildeHealthcare and @NorwestVP, to transform the standard of care for #PulmonaryEmbolism.

CEO Dan Rose and team have built the Hēlo® Thrombectomy Platform — combining clot-breaking and suction in a single streamlined catheter to tackle #VTE, the third leading cause of cardiac-related death, doing more in one pass where legacy systems fall short.

Honored to support E2 alongside @GildeHealthcare, @NorwestVP, Santé Ventures, 415 Capital, @panakes, and M&L Healthcare Investments.

Learn more 👉: https://t.co/I0PiuHuIpK

#MedTech #VTE #Thrombectomy #PulmonaryEmbolism

[S3 Ventures @S3ventures]

Have you heard? Our April newsletter is in the works!

Subscribe for the latest and greatest on our #portfolio wins, #startup resources, #CEOSpotlights, and more!

👉 https://t.co/FpOSCHGLhp

[S3 Ventures @S3ventures]

🎊 Shoutout to @InterplayLearn for being named one of @Forbes' America’s Best Startup Employers 2026—marking their fourth consecutive year on the list and a #2 ranking in Education and EdTech! 🏆

Read More 🔗: https://t.co/z45V7BaPzu

[S3 Ventures @S3ventures]

🎉 Another great SXSW investor dinner in the books.

Amid the pace of @sxsw 2026, it’s always meaningful to carve out time for a smaller, more intentional evening with peers across #VC. We appreciate everyone who joined us Sunday evening and helped spark so many thoughtful discussions.

If you’re a VC or senior investor interested in joining next year, share your information below 👇
https://t.co/yrxHHTSy2F

[S3 Ventures @S3ventures]

🤝 What a Friday! Thank you to everyone who joined us for our @sxsw panel on Venture Capital Trends in Texas and Across the US last week!

A huge thank you is also due to host @charlieplauche and our panelists @Oksana_ATX (@SputnikATX), @krishnasrini (@liveoakvp), and Morgan Flager (Silverton Partners) for sharing their insights on all things VC. From the IPO/M&A market reaching its third peak in a decade to $12.3B in VC funding invested in Texas companies (PitchBook-NVCA), 2025 showed real momentum. We can't wait to see what is in store for 2026.

#SXSW2026 #Startups #VentureCapital #TexasStartups #VCInsights