Excited that Channel 7 & 9 covered our @Cell_Metabolism study along with 62 news outlets. It suggests AP-1-linked chromatin opening drives organismal maturation across cell types by disrupting the activity of 'early-life' gene regulatory elements—a mechanism hijacked in aging via ongoing chromatin opening.
Our new @Cell_Metabolism study proposes a mechanistic connection between molecular remodelling in development & aging. We uncovered a common transcription factor pattern linked to chromatin remodelling in organismal maturation & aging.
Link https://t.co/Yyu1gLp8kK
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New! Online now: The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening https://t.co/LMhp2Mzfyv