Sarah Bolton

@UOregon Chemistry PhD candidate, @PluthGroup, graduating summer 2021, #scoducks

[Sarah Bolton @Sbolton56]

@Fluorist Hello- I found this tweet after googling this position from the Thermo site and am very interested! Could I get more details?

[Sarah Bolton @Sbolton56]

Check out my live poster session going on now on solubilizing the insoluble #SfRBM2020Virtual https://t.co/gUGsIWQkjD

[Sarah Bolton @Sbolton56]

Giving a poster presentation on my work in the @PluthGroup on solubilizing elemental sulfur for sulfane sulfur delivery to cells today at 1:30 PM PST/4:30 EST! Please check it out #SfRBM2020Virtual

[Sarah Bolton @Sbolton56]

@HaileyJKnox Yeah I don’t think there’s a way to change the S8 to H2S rate with the CD, just to modify how quickly S8 is released

[Sarah Bolton @Sbolton56]

My poster for #gaso2020 "Developing Methods of Biological Delivery of Sulfane Sulfur", H2S from elemental #sulfur itself! #Gaso2020H2S

[Sarah Bolton @Sbolton56]

@HaileyJKnox I do think it would be effective as a thiol activated donor in vivo, the main limitation is the fact that it has to be delivered with a large excess of cyclodextrin which could mess with cells

[Sarah Bolton @Sbolton56]

@HaileyJKnox Thank you! I hadn’t considered your first question before, since it’s not an actual chemical reaction releasing the S8 it would be different from tuning a synthetic donor...maybe modifying the core to make it more/less strongly binding to S8?

[Sarah Bolton @Sbolton56]

@profjeffchan @mdpluth Thank you, we tried smaller (alpha) and larger (gamma) and both had poorer fits than beta

[Pluth Group @PluthGroup]

Check out our recent @ChemRxiv preprint on a new approach to deliver sulfane sulfur / S8 to biological systems. Sheds light on new approaches for delivery, stabilization, and translocation of hydrophobic reactive sulfur species. Great work Sarah!
https://t.co/giA8HSjT7l