Jared Schrader

Enjoy all things related to RNA, RNPs, and biomolecular condensates. This account is inactive, find us on

[Jared Schrader @schraderlab]

Our lab is excited to share our latest preprint describing the BR-body proteome with huge help from @wschilders44 @JulieBiteenLab @ChampionNd and Elaine Zhu's lab @WayneStateEng @WSUBioSci
https://t.co/a8BWiziGNA

[bioRxiv Biophysics @biorxiv_biophys]

Stress Changes the Bacterial Biomolecular Condensate Material State and Shifts Function from mRNA Decay to Storage https://t.co/W1lpTBzW1L #biorxiv_biophys

[Taekjip Ha @taekjip]

Polyphosphate affects cytoplasmic and chromosomal dynamics in nitrogen-starved Pseudomonas aeruginosa | PNAS https://t.co/GhERjfc3Qz

[ShorterLab @ShorterLab]

A rapid inducible RNA decay system reveals fast mRNA decay in P-bodies: https://t.co/DfFHYk7TsQ

[eLife - the journal @eLife]

A conserved morphogenetic module that controls complex bacterial cell shapes. https://t.co/AzjyCkr5Mi

[Papenfortlab @papenfortlab]

Genome-wide profiling of Hfq-bound RNAs reveals the iron-responsive small RNA RusT in Caulobacter crescentus | mBio https://t.co/yZOygoAaTb

[brangwynnelab @brangwynnelab]

Congrats to former postdoc Felix Keber from our & @MartinWuhr lab on this fascinating paper using filtration experiments w mass spec to show that ubiquitous mesoscale condensate formation across >18% of the proteome. https://t.co/Xgo4D3Rg8O

[Achillefs Kapanidis @AchillesKap]

Our story on tracking the in vivo NusG whereabouts is on @MolecularCell! NusG rarely walks alone, enjoys 30S company, works out on anti-terminating and TT-coupling. True saga by brilliant @HAFEZELSAYYED, super support by
@ojp25 @M_Stracy and Max Gottesman! https://t.co/1tz5WIHaBI

[Matthew C. Good @buenoscience]

Thrilled to finally announce our work on the selectivity of disordered protein condensation in @NatureChemistry. Great collaboration with @JeetainMittal Led by @rmwelles and @kandarp_sojitra. https://t.co/b9ZO0g0Af1. See related work by Brangwynne lab https://t.co/HiUDH8vl9v

[brangwynnelab @brangwynnelab]

Excited to see beautiful manuscript led by @RanaUshnish & Kevin w @iAmAllAdhesion @M_T_Walls @javalosLAB & AZP out in @NatureChemistry (...after 5 mo. copyediting :( https://t.co/Zca8VdO0rJ Also see related co-submission by @buenoscience & @JeetainMittal https://t.co/WBS4LwjZ8K

[Anthony Vecchiarelli @CellfOrganized]

Interested in the mechanisms driving subcellular organization in bacteria?

The Vecchiarelli lab has a postdoc position available!

https://t.co/0GW7kzcOu5

Plz RT!

[Priya R. Banerjee @BanerjeeLab_UB]

Happy to see this one in the print 🙂 We describe how disordered prion-like domains can drive selective co-condensation of fusion oncoproteins with chromatin remodelers😎 Postdoc @richoodavis led this work with two talented grad students. 👏👏👏

https://t.co/6beIMD8AyL

[Manolis Maragkakis @em_maragkakis]

How does cellular stress affect #RNA? We sequence entire RNA molecules with @nanopore sequencing. We find 👉Global RNA decay mediated by XRN1, independent of poly(A) tail! 👉Decay absolutely depends on stress-granule formation! https://t.co/hwxlDxNuf1

[Nicolas Lux Fawzi @Nicolas_Fawzi]

Great to participate in this led by @HymanLab, Simon Alberti, @JeetainMittal and w/ @AyalaLab1, @titus_franzmann probing how cysteine oxidation aggregates TDP-43
Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates https://t.co/SG2njOEAdF

[Lars Barquist @LBarquist]

This is a very exciting paper with one of the clearest applications so far to take advantage of bacterial single-cell RNA-seq's ability to pull apart heterogenous gene expression within populations. Highly recommend! https://t.co/yQNQdinbRr

[Alex Bisson @Archaeon_Alex]

We have a new story out at BiorXiv! Amazing work led by @za_curtis (Bisson), Pedro Escudeiro (Alva) and John Mallon (Bisson).

Great collaboration with @Vikram_Alva (Max Planck) and @pohlschr (UPenn).

A summary of our findings in the thread (1/22)
https://t.co/qGvuQ7mwO1

[The EMBO Journal @embojournal]

What determines polar mRNA localization in E. coli?
Shanmugapriya Kannaiah, @OChoder et al @Hujimed find the polar transcriptome to depend on MinD inhibition of RnaseE recruitment
https://t.co/eTpUHranIy

[David R. Liu @davidrliu]

In a new paper in @Nature, an impressive and creative series of insights led @DDunkelmann and coworkers in Jason Chin’s lab to develop a powerful, general in vitro selection for aminoacyl-tRNA synthetase enzymes that charge tRNAs with a wide variety of small molecules, including those not necessarily compatible with known ribosome variants (yet). They used this system to create aaRSs that enable beta-amino acids and alpha,alpha-disubstituted amino acids to be site-specifically incorporated into proteins, solved the structure of GFP containing meta-brominated beta-phenylalanine as the third residue as confirmation, and advanced the non-canonical biopolymer field forward in the process.

Wow. Brilliantly explained in the thread below. 👏👏🍻

[Jared Schrader @schraderlab]

@AmyPalmerZinc @SmithLabUMBC There's two commercial solutions people suggested that have up to 3mm spacers, but one of my old Uhlenbeck lab-mates built custom rigs like Olke's https://t.co/uYzXOky9sl https://t.co/d0i2cujvFO

[Jared Schrader @schraderlab]

Anyone able to recommend vertical PAGE rigs for preparative RNA purification after T7 transcription? I inherited all my PhD Adviser Olke Uhlenbeck's old gel rigs when he retired, but they were all custom built, so I need to find commercially available replacements.

[bioRxiv @biorxivpreprint]

Late consolidation of rRNA structure during co-transcriptional assembly in E. coli by time-resolved DMS footprinting https://t.co/IS9JhE2a7G #bioRxiv