🚨Preprint alert #1🚨AI-driven spatial transcriptomics for a SC-pancreas transplant test case - fantastic collaboration with @ganoopyliujia@wenbowang11@ZuwanLin - checkout the youtube demo!
Sana Biotechnology's first-in-human study of hypoimmune-engineered deceased donor islets shows insulin production & immune evasion without immunosuppression #Diabetes#T1D#CellTherapy https://t.co/ynsDJKmP0o
Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”.
https://t.co/GKx6eslJz0
A tremendous collaborative effort led by @JohannaSiehler, @BilekovaSara and other members of the @LickertHeiko lab.
Online @Cell_Metabolism - a Focus on https://t.co/aAsQpIBqEu. Views on data accessibility, sharing, quality, and general thoughts on the field.
“https://t.co/SzapxteAFl: Improving accessibility, integration, and usability of human research islet data”
https://t.co/y9lrQob5M4
🧬 Exciting new study out in @NatureComms! We identify cell-type-specific responses in pancreatic islets to stress, shedding light on diabetes progression. It is #OpenAccess for all to download for free! #DiabetesResearch@WUSTLmed @WUDeptMedicine https://t.co/7s0534QwYu
Thrilled to announce we just got funded by @novonordiskfond Research Leader program!! We will explore the mechanisms behind islet cell maturation using human pluripotent stem cells. Recruiting PostDocs and PhD students really soon, get in touch ;) @STEMMProgram@helsinkiuni
Our most complex biologic system—immunity—is reviewed in 3 new @CellCellPress papers, open-access
Adaptive
https://t.co/rJRBnV7u8I
Innate
https://t.co/PMKA6KgL7R
New insights
https://t.co/rJRBnV7u8I @RMedzhitov
Endocrine-metabolic research at #WashUMed can be traced to the Nobel Prize-winning work of Drs. Carl and Gerty Cori. Among their trainees were Drs. William H. Daughaday and David M. Kipnis, who molded and led our division during the 1950s-1970s.
Read more: https://t.co/7ehUYrsnFR
We previously performed a study demonstrating AMX0035 improves in Wolfram Syndrome patient iPSC-derived islets with @FumihikoUrano. @amylyxpharma just announced interim clinical trial data with AMX0035 showing improved diabetes and vision! Congratulations! https://t.co/FweSU8FlRa
Great work from the lab and a thorough characterization of pig pancreas development and comparison to other species! Congrats to @Carina_K_YANG@HannahSpitzer1 and all authors for the highly collaborative project! See tweetorial from the boss below for more details on the work!
🗺️ Scientists charted a high-resolution roadmap with scRNA-seq to investigate pathogenesis of wolfram syndrome #βcell failure, revealing two distinct cellular fates along pseudotime trajectory: maturation and stress branches.
#OpenAccess in @cddpress:
🔗 https://t.co/hfkQUgRmdP
New from @HuisingLab @ucdavis The physiological role of δ cells and SST is to provide tonic feedback inhibition that reduces the β cell glucose threshold and consequently lowers the glycaemic set point in vivo #islets#diabetes@NatMetabolism https://t.co/bfnunRbmwV
A thing I ❤️ about my job is I'm lab-active. Semester is done; winter project going! 60 F1 hybrids; 500 plates poured for some F2s…time for some genetics! This will be a multi-day 🧵, which might become cautionary, about chasing an interesting observation w/dubious impact 1/n
Bright and sensitive red voltage indicators for imaging action potentials in brain slices and pancreatic islets | Science Advances https://t.co/J4VELofWUZ
Drs. Z. Ian Hu at @MDAndersonNews and Eileen O’Reilly at @MSKCancerCenter highlight contemporary areas of research for pancreatic cancer, including poly(ADP-ribose) polymerase inhibitors, KRAS-targeted therapies, and #immunotherapies.
https://t.co/OT1Xx9YtvG
Dr. Leete provides an overview of pancreatic anatomy, and the importance of research focused on the pancreas in #type1diabetes, which ranges from histological breakthroughs to briefly discussing the challenges associated with characterizing the organ.
https://t.co/4MDVwnuFZm