This has quietly been a miracle month in medicine.
In the last 5 weeks we’ve got news on:
- retatrutide, the triple agonist GLP-1 from Lilly, basically melting fat and body-wide inflammation at record levels
- RevMed’s new pancreatic cancer drug showing unprecedented abilities to extend life
- small trial of a one-and-done PCSK9 gene editing therapy for slashing LDL cholesterol
- Mayo’s AI-assisted radiology showing vastly improved cancer detection
- this new therapy for metastatic solid tumors
This stuff is at varying levels of evidence. Retatrutide is ~100% on its way, other stuff needs more clinical trial data. But put it together and we’re maybe on the verge of majorly reducing the mortality of heart disease and cancer, the two leading causes of death in America.
The businesses getting the most out of AI right now aren't tech companies.
They’re plumbers, agency owners, dentists, Etsy sellers.
New data from @OpenAI (cc @RonnieChatterji) makes the pattern clear: tech startups account for about 5% of ~active~ U.S. users doing entrepreneurial work with ChatGPT.
The other 95% are spread across services, retail, healthcare, and trades.
AI adoption for entrepreneurship isn’t concentrated in tech. It’s happening inside everyday businesses, folding into routine work that used to be slower or outsourced or entirely overlooked.
Attitude is a choice.
Gratitude is a discipline.
Bitterness is expensive.
Nobody accidentally has a great attitude.
Nobody stumbles into gratitude.
And nobody means to end up bitter, it just quietly moves in when you stop choosing something better.
Guard your peace like it cost you something.
Because it did.
Life rarely changes in a positive way without an increase in responsibility.
That can mean taking ownership of your health or committing to a relationship or starting a business.
Whatever it is, if you want the trajectory to change, the amount of responsibility usually has to change.