Selbach Lab

Real flying ion Circus studying the proteome and its dynamics @BIMSB_MDC @MDC_Berlin

[Selbach Lab @SelbachLab]

MEK inhibition + growth factor → unexpected JNK activation
💥 Dual inhibition = significantly impaired tumor cell growth
🔬 SPIED-DIA = a powerful tool to dissect signaling & resistance

#phosphoproteomics #cancerresearch #SPIED_DIA #MEKinhibition #DIA #precisionmedicine

[Selbach Lab @SelbachLab]

We present SPIED-DIA – a spike-in enhanced phosphoproteomics method combining DIA with targeted sensitivity to uncover synergistic signaling in colorectal cancer cells.

👉 [https://t.co/R4nL8acLu8](https://t.co/R4nL8acLu8)

[Selbach Lab @SelbachLab]

What happens to all those alternative transcripts?

👉 Many are translated
👉 Proteolytic processing adds even more diversity

Integrated mRNA & protein isoform landscape now out on bioRxiv!

https://t.co/AazRU6WXgl

#proteomics #transcriptomics #systemsbiology

[Selbach Lab @SelbachLab]

@michaelsteidel1 @DemichevLab Should be up by tomorrow the latest!

[Selbach Lab @SelbachLab]

Excited to share our new paper in MCP! 🎉 DIA with Spike-In SILAC (DIA-SiS) boosts proteome coverage and quantification.

Check it out: https://t.co/cKBh5FjlgE

#Proteomics #MassSpec #Research

[Selbach Lab @SelbachLab]

Celebrating summer with our annual group barbecue

[Selbach Lab @SelbachLab]

Read our latest preprint on targeted phosphoproteomics: "Spike-in enhanced phosphoproteomics uncovers synergistic signaling responses to MEK inhibition in colon cancer cells.": https://t.co/UdzO3X4XQt

#Phosphoproteomics #DIA #CancerResearch #Signaling #ColonCancer

[Selbach Lab @SelbachLab]

Read the latest preprint on medRxiv: Cross-platform Clinical Proteomics using the Charite Open Standard for Plasma Proteomics (OSPP)

[Ralser Lab @RalserLab]

Want to do absolute quantitative plasma proteomics, with an internal standard that costs you less than 1€ per sample? Have a look at our OSPP https://t.co/OuoBLuHLka

[Selbach Lab @SelbachLab]

Combining data independent acquisition with spike-in SILAC (DIA-SiS) improves proteome coverage and quantification. Read our new preprint on bioRxiv.

#SILAC
#DIA
#Proteomics

https://t.co/DCNP2uE1Mr

[Selbach Lab @SelbachLab]

Read our latest work on how phosphorylation in Intrinsically Disordered Regions (IDRs) affects protein-protein interactions in Nature Communications.

@TRrustemi

https://t.co/qyZ54OJ5Bd

#IDR
#phosphorylation

[Selbach Lab @SelbachLab]

Enjoy good lectures about DIA and the sun here in South Africa #UPSS2024

[Selbach Lab @SelbachLab]

We would like to congratulate Fabian @CosciaLab for being awarded the European Research Council (ERC) Starting Grant 👏.
#ERC
https://t.co/FLqlMHzTDs

[Selbach Lab @SelbachLab]

Wishing our institute, MDC-BIMSB, a very happy 15th birthday 🥳

https://t.co/oEzl9xSxia

#MDC
#BIMSB

[Selbach Lab @SelbachLab]

Our latest preprint investigates the pathogenic mutations of human phosphorylation sites that affect protein-protein interactions. Using peptide-based interaction proteomics, more insights regarding the transcription factor GATAD1 were unveiled. @TRrustemi https://t.co/PzOOiwXs2R

[Selbach Lab @SelbachLab]

Last week we went on a nice kayaking trip to Lübbenau/Spreewald 😃
#ProteomeDynamics
#MS

[Selbach Lab @SelbachLab]

We completed a 5x5 km team relay yesterday. Some of us already look forward to running again next year.

[Selbach Lab @SelbachLab]

Interested in joining our Proteome Dynamics lab in Berlin? We are offering a postdoc position: https://t.co/jPBN3OC4vR

[Selbach Lab @SelbachLab]

Looking for a method to identify drug targets? Our new paper on drug target identification by quantitative proteomics is now online: https://t.co/OIMhcO3Dvg

[Selbach Lab @SelbachLab]

Proteomics Pride @MDC_Berlin in celebration of #CSDBerlin #proteomics #pride #mdcberlin

[Selbach Lab @SelbachLab]

How can you predict kinase activity in phosphoproteomic data? This database allows you to do this, even for poorly annotated kinases. Read more in this new paper: https://t.co/93O0Wnlcyu”