Shira Eisman

PhD scientist studying human NK cell migration and development. Immunology + microscopy. Formerly in the @mace_em lab @ColumbiaMed @ColumbiaGenDev

[Shira Eisman @ShiraEisman]

🧵 Thrilled to share our paper in @JCI_insight from the @mace_em lab at @ColumbiaMed!

CXCR4 coordinates adhesion, migration, and development of human NK cells

What controls when developing NK cells move 🟢 and when they stop 🛑?

https://t.co/DTXjpFlnMR

[Shira Eisman @ShiraEisman]

Excited to see where this goes next 🎉

I’m especially grateful for @mace_em’s mentorship and support and to @HegewischSolloa, our coauthors and collaborators, the donors and patients, and the communities at @CSCIColumbia, @ColumbiaGenDev, and @KidsAtColumbia.

[Shira Eisman @ShiraEisman]

🧵 Thrilled to share our paper in @JCI_insight from the @mace_em lab at @ColumbiaMed!

CXCR4 coordinates adhesion, migration, and development of human NK cells

What controls when developing NK cells move 🟢 and when they stop 🛑?

https://t.co/DTXjpFlnMR

[Shira Eisman @ShiraEisman]

📣 Our data suggest that CXCR4 doesn't just tell NK cells where to go—it regulates how they interact with their environment once there.

Next questions: how is this stop–go balance tuned, what are the downstream signals, and how do they shape NK cell development and function?

[Shira Eisman @ShiraEisman]

Wow, what a Herculean effort this took! It has been inspiring to see. Beautiful work @SeungmaeSeo! The Mace Lab at it again! 🛼🛼🛼

[Shira Eisman @ShiraEisman]

An exciting season for the Mace lab! Congrats Niki!

[Shira Eisman @ShiraEisman]

So proud to be a small part of this massive endeavor. Congrats @HegewischSolloa, @janine_melsen, @mace_em, and everyone else! What an incredible resource this will be to the field!

[Evey Hegewisch Solloa, PhD @HegewischSolloa]

Excited to share that we have preprinted our work on defining the spatial localization of human NK cell developmental subsets in pediatric tonsil! Also check out our poster and talk at NK2023! @mace_em @ShiraEisman @MundyBosse @AmirHorowitz @janine_melsen https://t.co/73m7iJniBy

[Shira Eisman @ShiraEisman]

@adriancandelas @BrunetStphane7 @ManuelTHERY @GelinMatthieu @BenVianay @Lblanchoin Beautiful work! I’ve been eagerly awaiting a follow up to your previous paper with @ThomasXBessy! Did you look into CXCR4-CXCL12 in the context of asymmetric cell division? Especially considering @sarahrussellsci’s work on the role of CXCR4 for ACD in T cell development.

[Shira Eisman @ShiraEisman]

@rosslevinemd @RossLevineLab @cohesinlab @bowman_rl @lindemilesphd @gur_ola @shengfcai @JAK2TheFuture ❤️

[Shira Eisman @ShiraEisman]

@lindemilesphd @CincyChildrens @ChildrensCBDI YAY!!! ❤️

[Shira Eisman @ShiraEisman]

Anyone in Philly? Or want to be in Philly? Join @bowman_rl’s lab! He’s crazy smart, an amazing teacher, and the most giving mentor you could ask for! (And also shows appreciation for me on Twitter?!)