Sigtrans

[Sigtrans @Sigtrans]

Our new article: B7-H3 (CD276) in exosome biogenesis and the tumor microenvironment -a new therapeutic nexus
https://t.co/93h6sgQbge

[Sigtrans @Sigtrans]

Exploiting metabolic vulnerabilities to improve cancer therapeutics: Trends in Endocrinology & Metabolism https://t.co/sZdji4knOY

[William A. Wallace, Ph.D. @WilliamWallace]

Your muscles clear glucose in two different ways after a meal.
Most people only use one.

When you sit after eating, glucose disposal depends almost entirely on insulin signaling from the pancreas. That pathway works, but it has limited capacity, which is why post-meal glucose spikes are higher and longer.

When you move after eating, even lightly, a second pathway turns on in parallel.

Muscle contraction independently activates glucose transporters (GLUT4), allowing glucose to enter muscle without waiting for insulin. The result is faster clearance, lower peaks, and less strain on the pancreas.

What’s happening under the hood:
• Muscle contraction triggers GLUT4 translocation
• Glucose enters muscle directly
• Blood glucose falls more quickly
• Insulin demand is reduced, not replaced

This isn’t about burning calories or “earning” food. It’s about using the physiology you already have. Walking after meals doesn’t override insulin. It adds another clearance pathway.

That’s why timing matters.

[Sigtrans @Sigtrans]

I am extremely thankful to my students, collaborators, and the reviewers and editors for their valuable feedback that improved our manuscript.
https://t.co/mpVzo6nKgw

[Sigtrans @Sigtrans]

Artificial Intelligence-Large Language Models (AI-LLMs) for Reliable and Accurate Cardiotocography (CTG) Interpretation in Obstetric Practice https://t.co/CKtz5AyAz2

[Sigtrans @Sigtrans]

Circular RNA circCLASP2 promotes nasopharyngeal carcinoma progression through binding to DHX9 to enhance PCMT1 translation
https://t.co/LwrJHhMhkY

[Itai Yanai @ItaiYanai]

New work reveals the impact of anxiety & depression on PhD students.
"Anxiety and depression can have a substantially detrimental impact on graduate students’ experiences [..] and likely also contribute to increased time to degree and student attrition."
https://t.co/iNitLTuagj

[Sigtrans @Sigtrans]

The Chatbot's performance was as good as those of the very experienced human doctors. "Artificial Intelligence-Large Language Models (AI-LLMs) for Reliable and Accurate Cardiotocography (CTG) Interpretation in Obstetric Practice" https://t.co/OmsVZanyug

[Sigtrans @Sigtrans]

Autophagy: a critical mechanism of N6-methyladenosine modification involved in tumor progression and therapy resistance
https://t.co/ESJadgIuoH

[Sigtrans @Sigtrans]

AI Large Language Models (ChatGPT et al) in Decision-Making Support for Medical Oncology https://t.co/HXYYBKXsUp

[Sigtrans @Sigtrans]

Here's the latest 🗞 from [ Nature Communications ]: " Human papillomavirus-encoded circular RNA circE7 promotes immune evasion in head and neck squamous cell carcinoma" https://t.co/1lkYq3OoG9

[Mammary Cell News @MammaryCell]

Meet the SON of splicing! 👲 ✂️

Scientists identified SON as a novel RNA splicing factor that plays a critical role in regulating ErbB2/3 expression. #BreastCancerResearch

@BrJCancer | https://t.co/bYBRvM64Js

[Sigtrans @Sigtrans]

This work identified SON as a novel RNA splicing factor that plays a critical role in regulating ErbB2/3 expression, suggesting SON is an ideal therapeutic target in ErbB2-positive breast cancers. https://t.co/cLZIh3RgUX

[Trends in Biochemical Sciences @TrendsBiochem]

Other Review topics include:
📝 Evolution of the #HippoPathway
📝Re-evaluating #TRPchannel mechanosensitivity (@Charles_D_Cox @PooleLab1 @BorisMartinac)
📝Analysis of dual-function #isomerases
📝#NINJ1 in plasma membrane rupture (@broz_lab)
📝Protein #lipoylation

[Sigtrans @Sigtrans]

Protein lipoylation: mitochondria, cuproptosis, and beyond: Trends in Biochemical Sciences https://t.co/tFXNYgthzY

[Sigtrans @Sigtrans]

Geographical Disparities by AI Chatbots! https://t.co/vWHCbYVAmg

[Sigtrans @Sigtrans]

@DalmeetS @OPCW @cenmag ChatGPT responses varied significantly depending on where the questions were asked. https://t.co/Xeq37LFb2L

[Sigtrans @Sigtrans]

Disparities in medical recommendations from AI-based chatbots across different countries/regions. #Artificialintelligence
#Endometrialcancer #ChatGPT
#Disparity, https://t.co/ABPRzbbjDC

[Trends in Biochemical Sciences @TrendsBiochem]

Online now - the Review "Protein #Lipoylation: Mitochondria, #Cuproptosis, and Beyond" from Ming Tan and colleagues.

https://t.co/z1VDalbhN1

[Sigtrans @Sigtrans]

Protein lipoylation: mitochondria, cuproptosis, and beyond: Trends in Biochemical Sciences @TrendsBiochem https://t.co/tFXNYgtPpw