Simone Immler

Professor of Genetics and Reproduction @biouea
Founder and Scientific Director of Virilitas Labs Ltd

[Simone Immler @SimoneImmler]

We had a great end to 2024 publishing:

The Zebrafish Sperm Proteome
https://t.co/KUbz7Z7PsU

We described >5400 sperm proteins generating a great atlas for future work!

Spearheaded by PhD student @JaymeCohenBIO with great collaborators at @biouea and @JohnInnesCentre

[Simone Immler @SimoneImmler]

This is a simple parsimonious model to explain the evolution of lifespan extension by dietary restriction and other forms of stress that suppress fertility.
Happy to be part of this exciting study!

[Alexei Maklakov @AlexeiMaklakov]

1/8

Why does eating less extend lifespan? 🧬

We often think about saving energy or recycling waste - but we show how evolution acting on mutation load can generate longer life on low food 🧵

and preprint below:

🔗 https://t.co/xoP6WGq1Hb

[Dr. Alice Godden 🐠🐸🔬 @AliceGodden]

🚨Our new paper @SimoneImmler
FishPi: a #bioinformatic prediction tool to link #piRNA and #transposable elements
Read now in Mobile DNA >> https://t.co/0USpkO5VX2 ✅ Covers many species (more to come) ✅ GUI based software #TESky #zebrafish #transposons
@biouea
🐟🥧🥧🥧🥧🥟

[Simone Immler @SimoneImmler]

We had a great end to 2024 publishing:

The Zebrafish Sperm Proteome
https://t.co/KUbz7Z7PsU

We described >5400 sperm proteins generating a great atlas for future work!

Spearheaded by PhD student @JaymeCohenBIO with great collaborators at @biouea and @JohnInnesCentre

[Dr. Alice Godden 🐠🐸🔬 @AliceGodden]

🚨 Happy to share my latest preprint on #polarbear #transposon activity in response to diverging climates in #Greenland #TEsky 🐻‍❄🌞❄️��👩‍💻

[Dr. Alice Godden 🐠🐸🔬 @AliceGodden]

🚨Pleased to share our latest preprint on #zebrafish #geneexpression and #transposons in #sperm & #embryos exposed to social stress

[Simone Immler @SimoneImmler]

I finally caved and am now on bluesky - help me finding you and follow me there @immler.bsky.social and send me starter packs!

Thank you!

[Alexei Maklakov @AlexeiMaklakov]

We have PhD position advertised in evolution of ageing with Tracey Chapman and @SimoneImmler:

Please contact me if you have questions about the project or about this PhD programme

https://t.co/6xF38jlQJH

[Jen Perry @jennyperry]

Why is there so much diversity in male seminal fluid proteins?
Funded PhD position available with Tracey Chapman @biouea
Research team includes @WolfnerLab , @WHaerty , @SimoneImmler and me
https://t.co/vkO34A5kJn
Applications deadline Nov 25

[Simone Immler @SimoneImmler]

I am also incredibly proud of this preprint:

Gum Arabic (Acacia senegal) enhances reproduction and modulates the microbiota-gut-brain axis....
https://t.co/fmUVsDEbLB

Again a massive team effort by @Ko0L_J_ @asdfjohnny @AliceGodden @JaymeCohenBIO et al!

[Simone Immler @SimoneImmler]

@ItamarHarel Thank you, Itamar!

[Daniel Marcu @DrDanielMarcu]

Incredibly excited to share our preprint (https://t.co/eNPIHa1S2Z) from
@SimoneImmler’s Lab 🥳!

By harnessing genomics, proteomics, and phenomics, we show that selecting high-quality sperm within an ejaculate could reduce the risk of diseases in future generations 🤯!

[Simone Immler @SimoneImmler]

I am incredibly proud of this paper in preprint:

Within-ejaculate haploid selection reduces disease biomarkers in human sperm

https://t.co/bySTSaYBJD

It has been long in the making and has been a true team effort!
@danielmarcu @JaymeCohenBIO @AliceGodden @GAlavioon et al!

[Simone Immler @SimoneImmler]

I am also incredibly proud of this preprint:

Gum Arabic (Acacia senegal) enhances reproduction and modulates the microbiota-gut-brain axis....
https://t.co/fmUVsDEbLB

Again a massive team effort by @Ko0L_J_ @asdfjohnny @AliceGodden @JaymeCohenBIO et al!

[Simone Immler @SimoneImmler]

Selection within the ejaculate of men results in genetic changes in key genes involved in neurodevelopment, cell signalling and cell proliferation and that the 'fitter' sperm in an ejaculate exhibit reduced expression of biomarkers for neurodevelopmental disorders and cancers

[Simone Immler @SimoneImmler]

I am incredibly proud of this paper in preprint:

Within-ejaculate haploid selection reduces disease biomarkers in human sperm

https://t.co/bySTSaYBJD

It has been long in the making and has been a true team effort!
@danielmarcu @JaymeCohenBIO @AliceGodden @GAlavioon et al!

[Alexei Maklakov @AlexeiMaklakov]

Germline removal benefits males more than females - led by @martin_i_lind in @AgingCell : https://t.co/XAZO5Moqpo (see earlier bioRxiv link below). Stress resistance improved in both sexes. Remarkable congruence with killifish work https://t.co/nBtI1OSHp9 @ItamarHarel

[Alexei Maklakov @AlexeiMaklakov]

Reduced insulin/IGF-1 signalling upregulates two anti-viral immune pathways, decreases viral load and increases survival under viral infection in C. elegans by @E_Duxbury et al

[Simone Immler @SimoneImmler]

I am very happy to announce the recent publication of a beautiful theory paper with @mscott0106 and Karl Mackintosh (not on X) on the interactions between mating system evolution and haploid gametic selection in @PLOSGenetics

https://t.co/ExN0jWouRV

[Omar Ammar @OmarRawi89]

Merger of NYRA @YoungAndrology with @EAAndrology is highlighted in this society news article published in Andrology 🤩

https://t.co/MpHUluwIrx

@AndrologyASA