Sirius Capital

Biotech Specialist -

[Sirius Capital @SiriusStarCapi1]

Compliance off my back (didn’t get fired I swear) - will be active rest of year before new gig starts 📈📈📈

[Sirius Capital @SiriusStarCapi1]

$TRVI when uncooked alert?

[Sirius Capital @SiriusStarCapi1]

$KZIA still trades 1/7th $SNSE market cap

[Bull Stock Picks @Bullstkpicks]

$KZIA looking ridiculously undervalued right now!

Only ~$117M market cap while $CELC sits at $5.8B and $RLAY at $3B — both chasing PI3K/mTOR in breast cancer.

But $KZIA has the ONLY oral brain penetrant dual PI3K/mTOR inhibitor. Massive edge (20-30% of breast cancers hit the brain).

Early TNBC data already 3/3 responses (2PR + 1 confirmed CR in pembro-fail patient)

$46M cash, runway into 2029, zero debt.

I've built a sizable position.

I feel they may report strong data coming at ASCO.

DYOR - $XBI $INBX (tagging this one for those that followed me in it... it has a lot to run as well)

[Sirius Capital @SiriusStarCapi1]

$LCTX - under the radar cell therapy company could get some buzz as M&A heats up in the sector. Graphic shows why Opregen partner Roche/Genenetech could be natural buyer

[Sirius Capital @SiriusStarCapi1]

$APLS helping clean up some of the mess $WVE made

[Sirius Capital @SiriusStarCapi1]

Biggest contra long in my book is $APLS

Everyone despises the company and the drug. The drug provides no benefit and a modest slowing of progression in GA lesion size.

Was largest short in my book @ $70. Is a top 5 long in my book as of Friday.

[Sirius Capital @SiriusStarCapi1]

$WVE with 2 datasets this month in obesity and AATD Cannacord increases price target to street high $53 Price Target

[Sirius Capital @SiriusStarCapi1]

… presented without comment

[Biotenic @Biotenic]

$TRVI $TRML

[Sirius Capital @SiriusStarCapi1]

$SNSE bullish readthru to little $KZIA

PI3K/MTOR pathway is so back…

[Sirius Capital @SiriusStarCapi1]

Darwin Global just filed on $WVE

[Sirius Capital @SiriusStarCapi1]

Time to start buying $WVE, indeed.

[Seedy19 @seedy19tron]

• weekly commentary
• hedge fund returns update
• new multi bagger long idea
• big no show news re Miami conferences
Back to the old format since not many moves made this past week. $crvs -20% and $apge -15% on the shorts, saving the week for me since everything else has been weak. It’s been tough. $Lqda probably only other shining light. Puts for feb still jacked , market still expecting legal news imminently. I did cover $apge today to free up some margin.
$crvs think itll settle high teens not sure what the next catalyst that drives the stock up is, esp now momentum and hype has died. I had a bad time shorting towards the back of 2025, but glad to be able to turn things around. I will say this though some I found out recently that smart people added on the day of data, better to not be on the opposite side of their bets BUT for now I am correct
$nktr r/r is incredibly favourable here going into the readout and post $amgn OX40 news today. The narrative will shift and the cash concerns will be addressed imho.
I think it could be time to start buying $wve $ptgx add more $cogt $ovid
Q1 catalysts I’m bullish $cmps $nktr and bearish $goss $ctmx and $ocul (another one I got stick for but so far on the right side of sentiment)
I wanna go back into $prax Edelman likes it even at these levels.
I’m sad I didn’t short $pvla in the end. I think valuation shorts are back $inbx I’m going to start to press in Feb.
Another co I’m going to start shorting is $mbx , the M&A hype seems to be dying across the board. BP don’t seem to want to pay up at these levels. $azn just bought 8 long acting peptides for the price of 1 $mbx
$gpcr and $mbx both could be topping around here imho.
$abvx is holding up a lot of my activity that I mentioned above in the market. I’m definitely oversized but confident that even if I do nothing this name alone can significantly increase my account value by the end of the year. PATIENCE
Lastly, almost done with 2025 hedge fund returns. Still working on a few names , it’ll be the most complete list till date. Possibly over 60 hedge funds ranked top to bottom. Teaser: nearly half of the specialist funds underperformed the index $xbi . And there were some triple digit returns. AND a fund had negative 2025 returns too….
On the new long idea, I have been building a position today , will announce under this post after market closes. I am convinced it’ll will have returns higher than any in the biopick , shame it came onto my radar so late.
Lastly, $tern just dropped out from the Miami conferences .. watch this space could be a blockbuster M&A in AML space.

[Sirius Capital @SiriusStarCapi1]

$KZIA one of my “broken” recap names.

Own it for the PI3K/MTOR $CELC comp but interesting PR this am on the preclinical PD1 Degrader side

Amgen just copped Dark Blue for $880 mil for their preclinical MLLT1 and MLLT3 degraders

Multiple ways to win here… I think?

[Sirius Capital @SiriusStarCapi1]

A lot of air has come out of these hot recap names. L

$PALI -38% from peak (B group, Columbia Thread, Adage, ADAR)
$IVVD -40% from peak (RA, Janus, ADAR)
$KTTA -58% from peak (Coastlands, ADAR, Columbia Thread)
$KZIA -65% from peak (ADAR, Ikarian)

All should work in ‘26… imo

[Sirius Capital @SiriusStarCapi1]

@A_May_MD Thanks blood 🤝

[Sirius Capital @SiriusStarCapi1]

$LENZ -4%
$IBRX -12%
$NTLA -8%

I don’t make the rules!!

[Sirius Capital @SiriusStarCapi1]

Okay yes I suck at Twitter.

Short $NTLA
short $IBRX
short $LENZ

Entered all today. Sue me!

[Sirius Capital @SiriusStarCapi1]

@Chris4q432 lol look at stock today

[Sirius Capital @SiriusStarCapi1]

Okay yes I suck at Twitter.

Short $NTLA
short $IBRX
short $LENZ

Entered all today. Sue me!

[Sirius Capital @SiriusStarCapi1]

$CHRS $10 PT by Opco. Long

[Sirius Capital @SiriusStarCapi1]

@AaronRosenblum5 Forgot JSPR. Put it on the list! and don’t follow PEPG. Yes agreed on CALC know some holders

[Sirius Capital @SiriusStarCapi1]

$XBI everyone pumps the same consensus stuff on here… my CONTRA names that most hate that I think work in Q1 from here

$WVE
$CRDF
$APLS
$CALC
$MGNX
$FATE

[Sirius Capital @SiriusStarCapi1]

@BalaBioResearch IP goes out to 2037 I believe will check notes when back at screen. Think there is A LOT of competition coming in the next 5 years in GA and honestly don’t love APLS or ISEE drug (who does?) but they do real revs and some desperate pharma will acquire APLS imo to plug Rev gap

[Sirius Capital @SiriusStarCapi1]

@BalaBioResearch Yo! Have read a lot of your stuff. Dig it

Can you clarify the question? Currently share market with $ISEE drug. Or are you talking about IP

[Sirius Capital @SiriusStarCapi1]

@AaronRosenblum5 I like $KPTI

WVE contra bc know lots of ppl who hate it here including AF and some buyside guys I speak w