Steven Turetsky

[Steven Turetsky @SteveTuretsky]

@Just_Natalie_K @CMerandi @WeAreLinHealth feel like its similar to treating depression with SSRIs AND psychedelics AND exercise AND diet AND therapy. It's narrow to believe that only one thing is needed to cure or fix something. Multi-pronged approach is where all medicine has been heading for some time now!

[Steven Turetsky @SteveTuretsky]

@CMerandi @WeAreLinHealth There's a ton of research out there that complimentary care like this can be a useful supplement to opioids. Feels like there's lots of room in a broken pain management system for something that can be used in addition to traditional remedies.

[motif neurotech @motifneuro]

Motif has received FDA approval to begin the RESONATE EFS, the first clinical trial of our therapeutic BCI for treatment-resistant depression.

Read the full press release here: https://t.co/PtgLzvzgof

[Dan Knightly @DanKnightly]

For all the teenagers and young 20 somethings, I hope this Flyers team turns into your Richards, Carter and Briere .

[Aakash Gupta @aakashgupta]

Your brain processes self-talk through the same neural circuits it uses for actual speech. Broca's area, the auditory cortex, and the prefrontal cortex all fire when you're just thinking words silently.

This is where it gets wild.

When participants in an fMRI study repeated self-affirming phrases like "I am capable," their nucleus accumbens (the brain's reward hub) showed 30% greater activation compared to neutral phrases. The nucleus accumbens sits deep in the basal forebrain and receives dopamine signals that encode prediction errors. When you tell yourself something positive, your brain's reward circuitry interprets it as a success expectancy and primes the system to respond more vigorously to actual rewards.

The mechanism works in both directions. Negative self-talk suppresses dopamine release in that same circuit. Low tonic dopamine in the nucleus accumbens produces anhedonia, fatigue, and reluctance to start tasks. The symptoms most people call "lack of motivation" are often just a dopamine deficit created by their own internal dialogue.

Here's the practical piece. Ethan Kross at Michigan found that third-person self-talk ("You've got this" instead of "I've got this") creates psychological distance that reduces amygdala reactivity. The amygdala is your brain's threat detector. By using your own name or "you" instead of "I," you activate the same prefrontal override used in cognitive reappraisal, the clinical technique therapists use to reframe negative thoughts.

Your inner voice also activates the ventrolateral prefrontal cortex, which directly suppresses amygdala activity. A phrase as simple as "calm down, this is just a test" literally downregulates your fear response at the neural level.

About 25% of all human thought is inner speech. That means a quarter of your brain's daily processing is shaped by whether you're feeding it threat signals or reward signals. The circuitry doesn't distinguish between words you hear from someone else and words you generate internally. Both hit the same auditory processing regions.

You are, quite literally, your own most influential voice.

[Paul Hembekides (Hembo) @PaulHembo]

.326/.444/.744 (1.188 OPS)

Bryce Harper’s career slash line with a chance to clinch a series (or tournament).

5 HR (in 12 games), the last 3 of which have come in the 8th inning.

[Benjamin Ryan @benryanwriter]

NEW STUDY: No evidence to suggest medicinal cannabis is effective for depression, anxiety or PTSD

A landmark Lancet Psychiatry paper published today – the largest-ever review of the safety and efficacy of cannabinoids across a range of mental health conditions – found no evidence that medicinal cannabis is effective in treating anxiety, depression or post-traumatic stress disorder (PTSD).
https://t.co/t1MQ7Wxcxr
https://t.co/TDmZ7APfp1

[SportsCenter @SportsCenter]

🇺🇸 🇺🇸 🇺🇸

[Steven Turetsky @SteveTuretsky]

@BleavIn76ers TJ!

[Justin Lever ❤️⚾️ @JustinLever3]

Just had to win 1 freaking home game vs the Diamondbacks

[DAN KOE @thedankoe]

https://t.co/7l7Jef99QZ

[Vic Vela @VicVela1]

If you would’ve told 18-year-old me that in the year 2026, ESPN— during an NFL playoff game on Monday Night Football, no less— would pay tribute to the guy from the Grateful Dead who jumped around stage in short-shorts and a Madonna shirt… 😂 Love you so much, Bobby. ❤️ #BobWeir

[Steven Turetsky @SteveTuretsky]

@vibhu Or just do your job

[Frank Klose @FrankKlose]

I saw someone compare AJ Brown to Orion Kerkering on my timeline. Big difference: One of them stood and talked to reporters openly and honestly afterwards. One of them ran away.

[Eric Daugherty @EricLDaugh]

🚨 BREAKING: Anti-Khamenei Iranians are CLASHING with pro-Hamas white liberal women in Washington

You literally can't make this crap up.

The white liberal women support ISLAMIST HAMAS

The Iranians want to OVERTHROW the Ayatollah!

Liberals are insane

[Empire State Building @EmpireStateBldg]

Tonight we will shine in tie-dye to honor the life and legacy of Bob Weir @GratefulDead

[Big Cat @BarstoolBigCat]

Playing hell in a bucket in the stadium. More sad

[motif neurotech @motifneuro]

Today, we launched our patient registry and are accepting submissions from individuals with treatment-resistant depression (TRD) who may be interested in learning about potential future research opportunities.

Sign up here 👉 https://t.co/mzKkEM5Xyt

[Poaster Fluffhead @MinnieFluff]

A little backstory for this magical moment!
Trey Anastasio with Dave Matthews Band 8/14/07 (first performance post-arrest)

[Steven Turetsky @SteveTuretsky]

#FirePatullo