In Alzheimer's the presence of neurons with tau tangles is a close correlate for neuron loss BUT in new 2P longitudinal imaging work from the lab we show that neurons with tangles live while neurons without tangles die. I'm surprised, are you? @MGH_RI :
https://t.co/dc0yn9Qffg
In people w/ Alzheimer's, blood vessels are tortuous and irregular just like what we reported in tau models in 2018. In our new work, we show that there's a lot more perivascular tau than previously thought. Read about clear brains + vascular tau here: https://t.co/Bm3Ipwim6d
In a recent study published in the Journal of Brain, Behavior, and Immunity, researchers from @MGHNeurology and colleagues investigated MS and synapse damage from inflammation.
Read more: https://t.co/43nlyVmSYt @mghneurosci
Invisible tau and shunned neurons? A little teaser for work we have been doing with Brad Hyman and Ted Zwang. More to come soon (I hope)! https://t.co/Bxffm5bj39
Combined immunolabeling for tau and blood vessels in thick tissues reveals accumulation reminiscent of CAA?! This preprint describes what we've been up to recently: https://t.co/hbSF8g3kWj