Agata Sularz

IM Resident at Mayo Clinic | Clinician Investigator Track | Cardiology | Cambridge Grad | Views mine

[Agata Sularz @SularzAgata]

Link: https://t.co/YpElDSZk78

[Agata Sularz @SularzAgata]

What if the same CT used for TAVR planning could also predict long-term survival?

In 2,642 patients, a deep learning model quantified body composition to show that lower skeletal muscle and adipose reserves predict mortality after TAVR.

@adnanalkhouli
#cardiotwitter

[Agata Sularz @SularzAgata]

Grateful for the opportunity to attend the Hawaii Heart CV Imaging Conference through the generous IM residency attendance trip support. Learning what I love, alongside fantastic mentors and colleagues, in one of the most beautiful places—truly couldn’t ask for more 🌺🫀

[Mohamad Alkhouli @adnanalkhouli]

I’ve had the benefit of @ChetRihal mentorship for more than 10 years. If you’re serious about mentorship—either seeking it or providing it—this episode of the @MayoClinic human optimization project is a practical blueprint.

A few 💎 that stayed with me:

📌 Mentorship ≠ sponsorship. They’re related, but not interchangeable—and your career needs both. 

📌 The best mentors do more than teach skills—they help you see potential you may not yet recognize in yourself. 

📌 Don’t try to become a carbon copy of your mentor; the goal is to sharpen your professional identity. 

📌 Beware the “mentor as oracle” trap—strong mentorship supports judgment; it doesn’t replace it. 

📌 The endgame is growth: over time, you should increasingly be able to mentor yourself by clarifying your goals and internal drivers.

https://t.co/ehzRmeBjc8

[Agata Sularz @SularzAgata]

#AHA25: AI-enabled ECG “aging” reveals gene-specific differences in genetic CMP.
🧩 DSP & LMNA variants show the greatest biologic age acceleration.
🔗 AI-ECG age gaps mirror distinct LGE patterns, linking electrical and functional disease signatures. @MayoClinicCV @MayoMN_IMRES

[Dr. Filippo Cademartiri @FCademartiri]

🏛️ A 200-Year Journey Through Coronary Disease and Myocardial Infarction 💥
From bloodletting to genomics — the story of humanity’s fight against the #1 killer.

📜 🔹 Origins (1700s–1900s):
🩺 Heberden (1772) → first clinical description of angina.
🧠 Pathologists later linked it to coronary “ossification” and thrombosis.
⚡ Herrick (1912) defined myocardial infarction (MI) and promoted rest as therapy.
❤️ ECG transformed diagnosis (1919).

📈 🔹 Epidemiology & Risk Factors (1940s–1960s):
🧩 Framingham Heart Study (1948) unveiled risk factors: hypertension, cholesterol, smoking 🚬.
🩸 NHLBI launched preventive programs 🫶.
💡 Realization: CAD and MI are preventable diseases, not fate!

🏥 🔹 Coronary Care Revolution (1960s):
📊 Hospital mortality for MI = 30% 😱
👨‍⚕️ Julian (1961) → created Coronary Care Units: ECG monitoring, CPR, early defibrillation ⚡
💪 Result: In-hospital deaths halved.

🧰 🔹 Invasive & Interventional Era (1950s–1980s):
💉 Forssmann catheterized himself (1929) 😳
🎥 Sones developed coronary arteriography (1958).
🔧 Favaloro introduced CABG (1969).
🎈 Grüntzig pioneered angioplasty (1977) → foundation of PCI 💫
🧬 Cross-disciplinary teamwork reshaped cardiology forever.

💊 🔹 Modern Therapeutics (1970s–2000s):
🧫 GISSI & ISIS-2 ➡️ fibrinolysis + aspirin ↓ mortality.
🩻 PCI + stents revolutionized reperfusion 🚀
💊 ACE inhibitors, beta-blockers, statins, aldosterone blockers ➡️ longevity ↑.
⚙️ ICDs, CRT, LVADs transformed heart failure care ❤️‍🔥
🧬 Gene therapy (SERCA2a) emerging 🧪

🧬 🔹 Biology of Atherosclerosis:
🧠 Atherosclerosis = chronic inflammatory disease 🧨
💣 Plaque rupture → thrombus → MI
🧪 Furchgott, Ignarro, Murad → nitric oxide as endothelial relaxant → Nobel 1998 🏅
🧬 Brown & Goldstein → LDL receptor pathway discovery → Statins revolution 🏆

🧫 🔹 Molecular & Genetic Era (2000s–present):
🧬 Genomics, pharmacogenomics, stem cells, molecular targeting
🧩 Genome-wide studies reveal new genes for CAD (lipid metabolism + inflammation).
🧬 Personalized medicine emerges: warfarin genotype dosing, clopidogrel resistance (CYP2C19).
🌱 Stem cell therapy & cardiac regeneration — still early but promising 🌟

🌍 🔹 Global Cardiovascular Health:
CVD = #1 cause of death worldwide 🌎
Drivers: aging, smoking, sedentary lifestyle, poor diet 🍔
💡 Need: prevention, education, low-cost care, and global collaboration 🤝

💬 🔹 Take-Home Message:
From 1812’s “strangling of the chest” to today’s molecular cardiology,
our progress has been extraordinary — but the mission continues.
🫀 Prevention, innovation, and equity are our next frontiers. 🚀

📣 #Cardiology #NEJM #CAD #MyocardialInfarction #HistoryOfMedicine #CardiacImaging #Prevention #Atherosclerosis #Statins #PCI #InnovationInMedicine #HeartHealth #PrecisionCardiology

[Agata Sularz @SularzAgata]

Presented at #AHA25 on a case of NBTE + intraventricular small-vessel thromboembolic occlusion mimicking ICI myocarditis in a patient on pembro. Not all ICI-related troponin is myocarditis—multimodality imaging + histopathology matter. @MayoCVFellows @MayoMN_IMRES @MayoClinicCV

[Mamas A. Mamas @mmamas1973]

Unless there are fundamental comorbidities that preclude surgery such young patients shouldn't be having TAVIs.

Sure we can do such procedures with relatives ease- but it doesn't mean it's right for the patient. They have to deal with the consequences long after you or I have gone...

[Mayo Clinic CV @MayoClinicCV]

To close out @MayoClinic presentations at #TCT2025, @rajivxgulati takes the Main Arena stage to explore the Cath Lab’s role in SCAD management—part of the Acute Coronary Syndrome dilemmas session.

[Agata Sularz @SularzAgata]

What an amazing experience moderating at #TCT2025! Huge thanks to everyone for the thoughtful questions and lively discussions — I learned so much from you all. 🙌 @MayoClinicCV @MayoCVFellows @adnanalkhouli @MayoMN_IMRES

[Agata Sularz @SularzAgata]

Just presented at #TCT2025! 🎤

Our study shows magnetocardiography (McG) can rapidly and non-invasively detect total coronary occlusion in acute MI—supporting faster diagnosis & treatment. 💙 #Cardiology #Innovation @adnanalkhouli @MayoCVFellows @MayoClinicCV @MayoMN_IMRES

[Mayo Clinic CV @MayoClinicCV]

We’re excited to join colleagues from across the world at #TCT2025. Stay tuned for upcoming @MayoClinic sessions to hear how we’re helping shape research, education, and clinical practice. Or stop by booth #2341 to say hello & connect with our team. 👋w/ @MayoClinicCVS

[Agata Sularz @SularzAgata]

@adnanalkhouli @MayoClinicCV

[Agata Sularz @SularzAgata]

So excited to be back at #TCT2025—this time as faculty!

I’ll be moderating two imaging sessions on Monday, Oct 27:
🩺 Valvular Heart Disease (2 PM)
🫀 LAA Occlusion (5 PM)

TCT was my very first US cardiology conference—it’s special to return and help lead the conversation!

[Millie Marconi @MillieMarconnni]

Holy shit...Stanford just built a system that converts research papers into working AI agents.

It’s called Paper2Agent, and it literally:

• Recreates the method in the paper
• Applies it to your own dataset
• Answers questions like the author

This changes how we do science forever.

Let me explain ↓

[Sara Inglis @SaraInglisMBBCh]

Hemodynamic optimization of #CRT in an #LVAD patient using BiV #PVLoops
@JACCJournals

⭐️Optimal pacing determined by greatest benefit in BiV contractility and volume reduction

⭐️May serve as a strategy to guide individualized device optimization

https://t.co/BnYK9V1sQk

[Agata Sularz @SularzAgata]

@rajivxgulati @JACCJournals @claireraph @yadersandoval @marysia_tweet @SharonneHayes @mandeep_mayo Congratulations! ⭐️

[Rajiv Gulati @rajivxgulati]

Causes of MI in the Young!
The OCTOPUS study out in JACC today @JACCJournals
@claireraph et al

[Mayra Guerrero, MD @MayraGuerreroMD]

One hour workout followed by dinner together with Women In Cardiology @MayoClinicCV !!! A big thank you to our department leaders for their support. Proud and fortunate to be part of this wonderful team!!! 🙏😀❤️