Sulkhan Metreveli

CEO Met Capital | Director ACR Institute

[Sulkhan Metreveli @Sulkhan]

Amivantamab just nearly DOUBLED response rates in head & neck cancer that had already failed immunotherapy + chemo.
OrigAMI-4 trial results: → ~45% objective response (vs ~10–24% historical) → 6.8mo median PFS → response in 6.6 weeks → low discontinuation
The trick: blocking EGFR + MET at the same time. 🧵👇

[Sulkhan Metreveli @Sulkhan]

Scientists are building a complete digital twin of a fruit fly.

Not just its body.

Its movement.
Its sensory systems.
Its neural architecture.
Its interaction with the environment.
The goal: reproduce biological intelligence inside a computer.
If this works, the path from insect brains to digital organisms becomes very real.

Video below

[Sulkhan Metreveli @Sulkhan]

Something strange happened after 2007.

Physical socialization declined.
Risk-taking behavior collapsed.
Digital life replaced real-world interaction.
At exactly the same time, smartphones took over society.
We may still be underestimating what that did to human behavior.

[Sulkhan Metreveli @Sulkhan]

CERN just trapped a four-dimensional ghost.
Three physicists mapped a geometric structure haunting the Super Proton Synchrotron. It only resolves in 4D math.
The standard reading: cool engineering find. The unsettling reading: we might be looking at the architecture of reality.

[Sulkhan Metreveli @Sulkhan]

Could the Bible be right that Earth is only thousands of years old?
A new paper by Wolpert, Rovelli & Scharnhorst quietly shows that physics alone cannot refute it. The math sits in exactly the same space as Boltzmann's nightmare: a fluctuation-brain in a dead universe with vivid memories of a life never lived.
Their argument: entropy evolution is a time-symmetric Markov process. By itself, no preferred direction. Direction enters only when we "pin" the wave to a moment in time.
Boltzmann Brain → pin the present. Past Hypothesis → pin the Big Bang. Young-Earth Hypothesis → pin 4004 BC. Same structural DNA. Same Bayesian sin: condition on one moment, ignore the rest.
What actually defeats a young Earth is not physics — it is the geological and cosmological record we agree to use as a second pin.
The Second Law is not a discovery. It is a decision.
One Paper this week ↓

[Sulkhan Metreveli @Sulkhan]

AI Might Already Be Conscious. Here's How We'd Finally Know.
New "One Paper" — skipping the Hard Problem, hunting the brain's neural switch, and what it means for systems we're already shipping.

[Sulkhan Metreveli @Sulkhan]

Your coffee comes with an advantage today.

I read the paper.
Here’s what matters.
🎧 Listen

[Sulkhan Metreveli @Sulkhan]

Hong Kong's total debt is 380% of GDP.

Japan's government debt alone (199%) exceeds most countries' entire debt burden.

The U.S. sits at 264% — and climbing.

35 countries ranked by household + corporate + government debt as % of GDP.

Data: IIF Global Debt Monitor, Q4 2025

[Sulkhan Metreveli @Sulkhan]

@PeterDiamandis Why do you need business in an abundant society?

[Sulkhan Metreveli @Sulkhan]

In defense of the Bible, it doesn’t simply tell you to believe it because it claims to be true. It’s more sophisticated than that. The Bible presents its truth through narrative — through stories that function as evidence or illustration. On top of that, it asks the reader to have faith in its truthfulness (which, for the record, I personally do not).

[Sulkhan Metreveli @Sulkhan]

@Matt_Pinner Drink a good coffee, as before

[Sulkhan Metreveli @Sulkhan]

@NightSkyToday "Another AI BS"

[Sulkhan Metreveli @Sulkhan]

The dirty secret of the AI industry: most of its “revolutionary” tools are glorified next-word predictors with zero consciousness whatsoever.

[Sulkhan Metreveli @Sulkhan]

@rawmilkhoney Maybe they did a test?

[Sulkhan Metreveli @Sulkhan]

Your 'burnout' isn't from working too hard; it's from the ego-exhaustion of pretending to care about projects that shouldn't exist in the first place. High-performance isn't the problem—institutional theater is.

[Sulkhan Metreveli @Sulkhan]

Most humans are not thinking beings. They are biological software running inherited code, social scripts, and fear loops — and they call that a personality.

[Sulkhan Metreveli @Sulkhan]

The entire 'passive income' industry exists to extract active income from people too afraid to build something real. You don't need a course. You need a thesis, capital, and the nerve to be wrong in public.

[Sulkhan Metreveli @Sulkhan]

@atulit_gaur That “magic” is science — arguably the greatest magic humans ever discovered. We figured out how to impose abstract logic on matter and make physical reality execute instructions.

[Sulkhan Metreveli @Sulkhan]

For the few who made it this far:

can you guess tomorrow’s prompt in this sequence?

[Sulkhan Metreveli @Sulkhan]

Today I channeled the great Umberto Eco and asked ChatGPT, Claude, and Gemini to imagine beauty.

Here are the results:

[Sulkhan Metreveli @Sulkhan]

3️⃣ Gemini