Dr Stephen S. Barasa

I am a Senior Lecturer @UoE_Main #Organic #Chemistry #drug discovery, former postdoc @Pfizer UK @WHO tdr, researcher @rothamsted,PhD @OfficialUoM

[J. Am. Chem. Soc. @J_A_C_S]

On the cover of this week's issue: "Capturing the Conformational Heterogeneity of HSPB1 Chaperone Oligomers at Atomic Resolution"

Read it here 🔗 https://t.co/cF6WRGSUDG

[Dr Stephen S. Barasa @supersteveBChem]

@UoE_Main @UoMSciEng @ACSPublications @uonbi @OfficialUoM Pit Latrines Are Antimicrobial Pollution Hot Spots: Practical Circular Economy and Chemical Engineering Solutions | ACS Sustainable Resource Management https://t.co/VFzgQ27KK6

[Wellcome @wellcometrust]

Bioimaging is vital to the future of health research, but there are barriers to access and progress in the field.

Learn about our plans to overcome these barriers ⤵️
https://t.co/JNqiw8pfyV

[The University of Manchester @OfficialUoM]

What a view 🤩

[The Rockefeller Foundation @RockefellerFdn]

Explore The Rockefeller Foundation's efforts to bring clean, reliable energy and economic equity to millions. Dive into our Impact Report and see how we are making opportunity universal and sustainable

[Steve Wisniewski @stevewiz06]

We had to make this heterocyclic for one of our projects, and Vlad found this awesome way to make it without needing chiral chromatography. Check out our development of this CIDT! #BMSChemistry https://t.co/OHorPf7bGP

[drug hunter @drughunter_com]

Thyroid hormone receptor β (THRβ) agonists have seen a surge of interest in NASH, largely thanks to impressive Ph. III clinical data from resmetirom, a Breakthrough Therapy and 2022 Molecule of the Year candidate.

https://t.co/srJdr7nmS8

#chemistry #drugdiscovery

[Dr Stephen S. Barasa @supersteveBChem]

Obvious but not so obvious.....obviously! #NMR

[C&EN (Chemical & Engineering News) @cenmag]

Chemify is one of several organizations combining AI and robotics in automated pharmaceutical and materials discovery and synthesis labs. https://t.co/oCBTrBqSHu

[Johan A. Stenberg @Stenberg_JA]

Calling on plant ecologists and phytopathologists in FRANCE 🇫🇷
We need French collaborators to an ongoing EU wide project to obtain wild strawberry plants (Fragaria vesca) from your country. More info on how to join our network here:
https://t.co/kTT0HRDeCm

[The University of Manchester @OfficialUoM]

Meet the people driving teaching and learning excellence at Manchester.

#ManchesterMindMeet the people driving teaching and learning excellence at Manchester.

#ManchesterMindMeet the people driving teaching and learning excellence at Manchester.

#ManchesterMinds

[Dr Stephen S. Barasa @supersteveBChem]

Unusual

[C&EN (Chemical & Engineering News) @cenmag]

Chemists have discovered and characterized the first enzyme—known as JamD—that can tack either a bromine or an iodine onto terminal alkynes. https://t.co/PohThgFful

[Dr Stephen S. Barasa @supersteveBChem]

Profound!

[April Lukowski @AprilLukowski]

We went on the hunt for halogenases with new substrate preferences and found much more than we bargained for! In a collab between @moorelabsio and @GerwickL, we characterized the first enzyme capable of generating haloalkynes. A ��:

https://t.co/EdhzcqRYtX

[AstraZeneca @AstraZeneca]

Cardiovascular diseases, like heart attacks, heart failure and strokes, often coexist with metabolic disorders such as diabetes and obesity. These conditions share common risk factors and biological pathways, affecting our hearts and metabolism simultaneously.

[Abhik Ghosh @abhikghosh]

Nickel in biology: major insight into the Wood-Ljungdal pathway. https://t.co/QkAd4i8ZLh

[🔬 RicardoMontes @_MCRicardo_]

A Critical Rev of Kaempferol (Kf) in Intestinal Health & Diseases
▶️Kf enhances the production of coenzyme Q
▶️Kf is present in 🍎,🍇,🥦, 🍵...
https://t.co/vdD7HF8RhR @ToshiyukiHorie @EwingT_PhD @dronita_de @_INPST @IberianCitizen
The beneficial effects of Kf on the intestine

[Madam Mitochondria @Madam_Mito]

Cocoa Flavanols Enhance #Mitochondrial Function in Skeletal Muscle and Modify Whole-Body Metabolism in Healthy Mice.

https://t.co/tgjWhz4wlE

[Dr Stephen S. Barasa @supersteveBChem]

My son Joseph Super Barasa presenting at the national science and engineering fair in Nairobi today. Congratulations Son. I am very proud of your achievement. #STEM #Science #engineering

[Total Synthesis @TotalSynthesis]

#TotalSynthesis of abeo-Steroids via Cycloaddition Strategy by Long Min, Li-Ping Zhong, and Chuang-Chuang Li at @SUSTechSZ in @ACSPublications Accounts of Chemical Research https://t.co/M67PbLMgBS

[drug hunter @drughunter_com]

More LRRK2 On-Target Toxicity?

On Sunday, it was disclosed that additional, likely on-target adverse findings were observed in a primate GLP study on long-term treatment with Merck’s impressive LRRK2 inhibitors.

Key learnings summarized here: https://t.co/BPGO1xr1tH