Excited to share our recent review article that brings together emerging insights into collagen O-glycosylation. Grateful to @trayambakbasak , @dkumar02 and @CompCatLab for their constant guidance and support and @GhoshSusovon9 for the collaboration and shared efforts.
Disordered regions are not necessary for phase separation, in fact sometimes they inhibit it. The dimerization domains of PGL-3 are multivalent, necessary, and sufficient for LLPS into P-granules. As we show with @Seydouxlab in this @emboreports paper https://t.co/FRR2DTFcoa
Intrinsically disordered proteins are dysregulated in disease, but have been considered 'undruggable'. This Review in the October issue discusses experimental and computational approaches to conquer this barrier in drug discovery
https://t.co/CtK66DUq4y
https://t.co/uCOjGSckx8
Happy to share our community note published in Nature Communications. In this 14-page article (34 authors from 9 countries), we discuss current practices in biomolecular phase separation and hope it will be useful to the biomolecular condensate community.
https://t.co/UgwnvPpOk2