SWB Guardians of Resistance

Antimicrobial stewardship team, Sandwell and West Birmingham NHS Trust. All views are of our own.

[SWB Guardians of Resistance @SwbGuardians]

Promoting Antimicrobial stewardship at SWB https://t.co/WH03lFYus2 #AntibioticGuardian #AntibioticResistance #spreadawarenessstopresistance #KeepAntibioticsWorking #WAAW2021

[salujat @salujat1]

Exemplar ITU consultant sets the standard truly the best 👍👏👏
Keeps watch above the elbow, passing the test!"
complying with BBE policy @SWBHnhs @IpcSwbh @melrobe08536915 @MrDShakespeare1 @SwbGuardians

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

Echinocandin Vs fluconazole step down in patients with candida glabrata candidaemia?
🆕💫Retrospective,single-centre cohort study #JAC
No significant difference in treatment duration,incidence of persistent candidaemia or 30d clinical failure between 2 gps
https://t.co/D09j4Ubexd

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

Tazobactam does not inhibit AmpC-mediated hydrolysis of TOL and demonstrates poor binding affinity for both wild-type and mutant AmpC enzymes
🆕💫 #AAC
Restoring ceftolozane susceptibility: a role for diazabicyclooctane β-lactamase inhibitors #idxposts
https://t.co/Bu6LtNeGCJ

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

**Starting 2025 with a key update:
The new ATS/CDC/ERS/IDSA guidelines on treating drug-susceptible and drug-resistant tuberculosis (TB) are out!
What do you think about these changes? How will they shape clinical practice moving forward?**
#idxposts

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

In the context of emergence of cefiderocol resistance and of limited therapeutic options, the in vitro determination of cefiderocol susceptibility with a robust method is essential!
🆕💫Cefiderocol susceptibility testing: the challenge of disc diffusion
https://t.co/ZVh0AEL2a8

[Siddhant Shetty @Dr_ShettyID]

🔹Penicillin Binding Proteins🔹

⚡ Enterococci are relatively resistant to cephalosporins since Cps act through PBP2/3 while Enterococci use PBP4/5

⚡ MRSA are resistant to anti-Staph Penicillins by altering PBP2 ➡️ PBP2a through mecA/C

#MedTwitter
#IDTwitter
#JustIDThings

[Timothy Li @drtimothyli]

AmpC-producing Enterobacterales:
Expected phenotypes for wild-type strains and in cases of AmpC derepression and ESBL production

https://t.co/oQUPCAuoWO

[Jasmine Sethi @JasmineNephro]

🫀New Dukes criteria for Infective endocarditis

✅ E. faecalis is classified as a typical cause of IE

✅Inclusion of cardiac CT/PET for IE diagnosis

✅Surgical inspection of cardiac valve included as major clinical criteria

[Marc Mendelson @SouthAfricanASP]

Day 4 #WAAW2024

50% all antibiotic prescriptions are unecessary.
Time to hold prescribers accountable:

[RE] EDUCATE - yourself & remember what antibiotics are used for

ADVOCATE - for proper use

ACT NOW - be accountable change your role from driving to mitigating this crisis

[Pharmacy Infection @LTHTAntibiotics]

Blood cultures are 🔑 to detecting bloodstream infections & fighting #sepsis; we need them to optimize antibiotic prescribing. Let’s improve the blood culture pathway for better patient outcomes. #AntimicrobialResistance #AMR #AntibioticGuardian #KeepAntibioticsWorking #WAAW

[SWB Guardians of Resistance @SwbGuardians]

#WAAW2024
#AntimicrobialResistance
Promoting good antibiotics prescribing
To use antibiotics prudently and protect their effectiveness for future

[UK Health Security Agency @UKHSA]

This week is World AMR Awareness Week. We can all play a part in the fight against #AntimicrobialResistance. If you're prescribed antibiotics:

Don't save them for later 💊
Take them as directed 👩‍⚕️
Don't take them for colds and flu 🚫

#WAAW

[Syed Gilani @Syed_AD_Gilani]

#WAAW2024 Day 3 theme "optimising diagnostics" our Trust's CEO making the pledge.

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

Fantastic 🆕️🔥Review by @SIDPharm 🌟 @ChrissKonig @PharmacoJournal
Evolving resistance landscape in gram-negative pathogens: An update on β-lactam and β-lactam-inhibitor treatment combinations for carbapenem-resistant organisms
@Inox94 🙏 #idxposts
https://t.co/iVWL2cLaBD

[Juan Pablo Sánchez Navarro @melarsoprol7]

Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and emerging treatment

https://t.co/2YWKOQIKYq

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🔥Everyone's favorite #shorterisbetter table is updated
Wow, 4 RCTs [non S.aureus] bactremia
7= 14
Spread the word #shorterisbetter #idxposts

[Abid Hussain @MicrobLog_me_uk]

No evidence of difference in mortality with amoxicillin versus co-amoxiclav for hospital treatment of community-acquired pneumonia - Journal of Infection https://t.co/2gl5uppLIl

[ID:IOTS podcasting / idiots-pod.bsky.social @IDiots_pod]

Lets talk about Antibiotic PK. This week's 🧵: Distribution!

This is where the drug goes after it's absorbed/injected. Where it goes = what target sites it can be used at.

Main drug factors: Hydrophilic vs Lipophilic, plasma protein binding, and peripheral tissue binding

1/9

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

Is de-escalation from echinocandins to azoles a safe strategy in patients with candidemia?
🆕️🔥Systematic review & meta-analysis evaluating the clinical outcomes of antifungal early DES (<7d) in Candida infections in a relatively large sample size
https://t.co/OZyAegY72R

[Abi Jenkins @DrAbiJenks]

How many nurse hours could your Trust release on introducing an effective #IVOS pathway?

The numbers are eye watering, take a look!👇🏻

#BSACWinterConference