Jake Wintermute 🧬/acc

Synthetic Biologist - Foundry Theorist - American Wetware - stay humble biodesigners

[Jake Wintermute 🧬/acc @SynBio1]

Stop glamorizing the hustle and start glamorizing the mussel

[Tom Knight -- e/🦀🌴 @TomKnightSynBio]

Screening is increasingly impractical with massively parallel DNA pool construction, followed by assembly. Current screening relies on rejecting very limited target sequences from known pathogens. Likely worth it, but do realize the extreme limits.

[Jake Wintermute 🧬/acc @SynBio1]

@baym 96 I counted

[Jake Wintermute 🧬/acc @SynBio1]

Biosecurity threat level omega

[Champagne Joshi @JoshWalkos]

Bro was genuinely scared to death. 😂 🤣

[Jake Wintermute 🧬/acc @SynBio1]

@p_maverick_b I can still smell the camels on the drapes

[Jake Wintermute 🧬/acc @SynBio1]

He just like me fr

[Hunter Biden @HunterBiden]

@Kenneth_Belkin Do I look like I’m a part of the elite oligarch class. This was taken at a super 8 motel off I95 by the way.

[Michael Baym @baym]

Preventing bad actors from creating synthetic versions of dead plagues is a good thing, but doing it while also disarming our ability to control real biothreats like screwworm and natural pandemic respiratory viruses is pretty much the definition of biosecurity theater

[Jake Wintermute 🧬/acc @SynBio1]

Peep my boi @p_maverick_b at 2:34

[MTS @MTSlive]

OPEN LETTER ON BIOWEAPONS | MYTHOS RELEASES SOON | TSMC SUPPLY SHOCK https://t.co/qMa0YXxy3t

[Michael Baym @baym]

You: The world needs more bioproducts
Me: Behold, the biblically accurate 96-well plate

[Jake Wintermute 🧬/acc @SynBio1]

@cas_smith 🧑‍🍳👌

[Jake Wintermute 🧬/acc @SynBio1]

https://t.co/gr34TbfcmN

[Matthew F. McKnight @matt_f_mcknight]

(1/2) I signed, this is important work - but we need to be really careful to not get distracted from the bigger problem of rapidly decentralizing capabilities to create / deploy biothreats. Detection, identification, response - globally and persistent/pervasive - should be the top priority.

DNA synth will be distributed, it won’t be centralized in a way that can be effective with this approach. Desktop, at home, new synthesis tech coming, etc. Not to mention we can’t regulate China, etc. and this is a globally distributed technology.

This kind of legislation is sort of like telling people not to write viruses on all their home computers or, worse, if they do we will monitor them all to see what they type (which people would get around of course). Important now, not practical in medium/long run.

Necessary to reduce some risk, not nearly sufficient… nor where our top priorities should be.

Only practical thing is to make detection and response work great, global, and fast.

[Jake Wintermute 🧬/acc @SynBio1]

"So they tried to make a sourdough loaf"

[Christina Agapakis @thisischristina]

I appreciate that my friends know me well enough to send me this article about scientists making sourdough with cold-adapted yeast found inside a 5000 year old corpse, makes me feel seen

[Jake Wintermute 🧬/acc @SynBio1]

Bioproduct idea a thesis that will defend you

[Jake Wintermute 🧬/acc @SynBio1]

@owl_posting @draparente fr fr fr fr fr fr

[Jake Wintermute 🧬/acc @SynBio1]

@0x1F9ED I’m jealous of your experience with core facilities and CROs if you see them as acting with urgency and shipping results on week timescales

[Drew Volpe @drewvolpe]

"If you’re a biologist and you’ve never tried solving a problem that absolutely needs to ship next week, I recommend it. It is a thrilling change of pace."

[American Wetware @americanwetware]

What drop-shipping pixel art taught me about curing all diseases
(The case for shallow tech in biology)

[Jake Wintermute 🧬/acc @SynBio1]

Me putting on my businessman persona in preparation to post something on linkedin