Synaptic Plasticity & Memory Lab

How are memories formed, retained & lost? Our team tackles this question via electrophysiological, biochemical and behavioural tools. *Student-run*
Based in NUS

[Synaptic Plasticity & Memory Lab @SynPlasLab_NUS]

Great to be invited to speak at the 17th International Conference of Neurons and Brain Diseases today! @sajisaaj

[Synaptic Plasticity & Memory Lab @SynPlasLab_NUS]

In the recent #FENS2024 hosted by @FENSorg, our lab from Singapore presented 2 posters. Enjoyed meeting old friends and making new friends in neuroscience. Always a pleasure to share science.

[Synaptic Plasticity & Memory Lab @SynPlasLab_NUS]

Our lab's latest review on #synaptictaggingandcapture (STC) is now out in open access: https://t.co/gqELauOJwI

This article is part of the "Long-Term Potentiation: 50 Years On" meeting by the Royal Society. In it, we consolidated STC work on #neuro physiology and pathology.

[Synaptic Plasticity & Memory Lab @SynPlasLab_NUS]

Congratulations to the 9th PhD student from SPM lab, Zaki!

[M Zaki Ibrahim @ZakZakiIbrahim]

Defended my thesis last Tuesday, May 21!! Thank you to everyone whom had supported me through this arduous journey!

[M Zaki Ibrahim @ZakZakiIbrahim]

Defended my thesis last Tuesday, May 21!! Thank you to everyone whom had supported me through this arduous journey!

[Synaptic Plasticity & Memory Lab @SynPlasLab_NUS]

Saji's 9th PhD student is defending his thesis tomorrow. All are welcome - all the best!

[M Zaki Ibrahim @ZakZakiIbrahim]

I will be defending my thesis tomorrow at NUS MD9! Do drop by if you're free!! There will be refreshments!

DM me if you need a Zoom link! It is hybrid. See you there and wish me luck!

[Synaptic Plasticity & Memory Lab @SynPlasLab_NUS]

Celebrated @sajisaaj's birthday today and all the May babies in the SPM lab - instructor Dr Wong Lik Wei and PhD student Penny. Happy birthday!!

[Synaptic Plasticity & Memory Lab @SynPlasLab_NUS]

Go to the link below to access the book! https://t.co/4FLiEY73dB

[Synaptic Plasticity & Memory Lab @SynPlasLab_NUS]

Latest edition of Synaptic Tagging and Capture book now out! Get the eBook or hardcopy now! A great effort in the latest book by editors @TedAbelneuro @sajisaaj

Congrats to all the authors for contributing - a testament of STC's relevance in understanding plasticity.

[Synaptic Plasticity & Memory Lab @SynPlasLab_NUS]

In today's preclinical session for the 7th Singapore International Neuro-Cognitive Symposium, Saji presented on metaplasticity and possibilities to rescue synaptic dysfunctions in Alzheimer's disease. #neuro #7nsc #singapore

[M Zaki Ibrahim @ZakZakiIbrahim]

A little late - I was at the #SfN2023 meeting presenting my poster! Always a pleasure presenting science and meeting scientists.

[Synaptic Plasticity & Memory Lab @SynPlasLab_NUS]

Today is Day one of the LTP meeting! Join us online! https://t.co/Ym1M6lip5c

[Synaptic Plasticity & Memory Lab @SynPlasLab_NUS]

SPM Lab represent! #neuroscience

[M Zaki Ibrahim @ZakZakiIbrahim]

Last Friday I presented part of my #PhD thesis work in the Singapore Neuroscience Association Symposium 2023! It was great sharing my work and getting feedback during the talk and offline too. #neuroscience

[M Zaki Ibrahim @ZakZakiIbrahim]

Excited to be a short talk speaker for Singapore Neuroscience Association Symposium 2023: Synapse, Circuit and Brain Function!

[Synaptic Plasticity & Memory Lab @SynPlasLab_NUS]

Yesterday, we celebrated our visiting post-doctoral fellows' birthdays during our lab meeting! Happy birthday, Dr Sheeja and Dr Cai!

[Synaptic Plasticity & Memory Lab @SynPlasLab_NUS]

Last month, we had a lab BBQ at Saji's place. It rained a little but we still persevered. With the summer interns, our lab really grew in size!

[Synaptic Plasticity & Memory Lab @SynPlasLab_NUS]

Last week, we did a journal club of a pub which Saji's first PhD student is the corresponding author of. It is also the first student-as-corresponding moment for him. Congrats to Qin! Looking forward to more exciting papers to have JCs with.

[Synaptic Plasticity & Memory Lab @SynPlasLab_NUS]

Our results show that this p75NTR-mTOR pathway could be key to understanding and ameliorating cognitive impairments in aging.

[Synaptic Plasticity & Memory Lab @SynPlasLab_NUS]

We just published a paper on the inverted role of mTOR in CA1 synaptic plasticity of aged male mice. https://t.co/T5FNYsdgyi

[Synaptic Plasticity & Memory Lab @SynPlasLab_NUS]

Yet in aged mice, mTOR inhibition rescued aging-induced impairments in LTP. Instead, mTOR activation blocked LTP. These effects were lost in p75NTR knockout mice, which suggest the presence of a molecular pathway between aging, mTOR and p75NTR.