๐ Mupirocin ointment is used nasally in postโtransplant patients to decolonize Staphylococcus aureus (including MRSA) from the nares, significantly reducing the risk of serious surgical site infections, exitโsite infections & nosocomial sepsis in immunocompromised hosts.
โข Transplant recipients have high S. aureus infection risk due to immunosuppression, indwelling catheters & surgical wounds, nasal carriage is a key source of endogenous infection.
โข Mupirocin applied intranasally twice daily for 5 days (perioperative) or as prophylaxis eradicates nasal S. aureus in 80โ90% of carriers, cutting infection rates by up to 68%.