Tuomo Mäki-Marttunen

Computational neuroscientist interested in neuronal electrophysiology and plasticity at a cellular level and mechanisms of heritable mental disorders

[Tuomo Mäki-Marttunen @TuomoMM]

Our paper on GABABRs is out https://t.co/gMvVrDO4sN
In this paper, we model both pre- and postsynaptic actions of GABABR activation in a biochemically detailed manner - check it out :)

[Tuomo Mäki-Marttunen @TuomoMM]

Our university made a small press release of our new article: https://t.co/ZWIaIqezqL

[Tuomo Mäki-Marttunen @TuomoMM]

Our paper "Genetic mechanisms for impaired synaptic plasticity in schizophrenia revealed by computational modeling" is now published in pnas: https://t.co/aik93Uvw9x :)

[Tuomo Mäki-Marttunen @TuomoMM]

https://t.co/hTrG5DKea1
A small introductory video was made about our Computational Neuroscience research group in Tampere University (in Finnish only, sorry!)

[Tuomo Mäki-Marttunen @TuomoMM]

Our paper on the role of Ih channels and their neuromodulation in L5PCs is out: https://t.co/MtutmodbCx
We've however only scratched the surface of computational modelling of neuromodulation of pyramidal cells, looking forward to working on this topic more in the future :)

[Tuomo Mäki-Marttunen @TuomoMM]

A cool analysis by colleagues on expression of pre- and post-natal expression of genes associated with schizophrenia.

[Dennis van der Meer @DvdM33r]

New preprint!! We found: 1) two schizophrenia gene sets with pre- versus postnatal cortical expression, 2) these sets associate with distinct neurodevelopmental processes, and 3) set-specific polygenic scores interact to predict diagnosis. Read more: https://t.co/vI5FM2drSV

[Tuomo Mäki-Marttunen @TuomoMM]

My ex-colleague Alessio wrote a fascinating article on fitting neuron models based on using MEA data in addition to patch-clamp data. IMO this is an important step toward making spatially more realistic neuron models, a dream we had in https://t.co/5aWwnl9jEZ by means of VSD.

[Alessio Buccino @buccino_alessio]

#tweeprint time!

We are excited finally share the results of a fun and productive collaboration between @bel_ethz and @BlueBrainPjt!

We explored the combination of patch clamp and high-density MEA to build detailed multicompartment models. Here's what we found 👇
(1/6)

[Christoph Metzner @ChristophMetzn1]

New paper out in @schizjournal linking ScZ-associated genetic variants to changes in 40Hz ASSR power in schizophrenia using biophysically detailed models with @TuomoMM @gili_karni Hana McMahon-Cole and @steuber_volker https://t.co/ysswPTGUpb

[Tuomo Mäki-Marttunen @TuomoMM]

In my past modelling studies I've always had to use guesswork when someone asked me whether the Ih has excitatory or inhibitory role on neuron activity. Here, in this paper I wrote with Verónica, we study the question in layer V pyramidal cells in detail for many types of stimuli

[bioRxiv Neuroscience @biorxiv_neursci]

Excitatory and inhibitory effects of HCN channel modulation on excitability of layer V pyramidal cells https://t.co/BECfN6q9Y4 #biorxiv_neursci