Verena Körber

[DKFZ @DKFZ]

#Cancer does not develop overnight. Researchers at the DKFZ have now developed a method that allows for the first time to reconstruct the evolution of cancerous cells from a single tissue sample.
https://t.co/ZO7DeKLZKw

[Verena Körber @VeKoerber]

@Adrien_Jolly_ @pvyas_oxford @asger_jakobsen @NaserAnsariPour Thank you, Adrien!

[Verena Körber @VeKoerber]

Our paper on detecting and quantifying clonal selection from a single bulk sequencing sample is out! This was a great collaboration with @pvyas_oxford, Thomas Höfer, @asger_jakobsen and @NaserAnsariPour. Read the full story here: https://t.co/bpA30Lyy9Q

[Verena Körber @VeKoerber]

SCIFER is broadly applicable to whole genome sequencing data from somatic tissues and available here: https://t.co/Io03d9HscB

[Verena Körber @VeKoerber]

We then studied WGS data from human brain, finding pervasive clonal selection emerging early in life. In 2 cases, selection was associated with mutations known from brain cancer, suggesting pre-neoplastic expansion. For most cases, however, the cause of selection was unknown.