Willem Lybaert

Medisch Oncoloog VITAZ - UZA Belgium. Board member and Secretary BSMO, Vice-President NETwerk ENETS CoE, President VWHHT.

[Anirban Maitra @Aiims1742]

Data from Tango slide deck of PRMT5inh plus KRASinh (Daraxonrasib, left and Zoldonrasib, right) in 2nd/3rd line #PancreaticCancer
https://t.co/4WANawY4iY

In this recent study (Boston Gene), ~20% of pancreatic cancers have KRAS mut plus MTAP co-deletion.
https://t.co/XHwHtlpjYy

[Thor Halfdanarson @OncoThor]

Time for routine germline genetic testing in NETs yet...? Based on this, pathogenic variants are seen in 15.9% of unselected patients with NENs and almost 22% in patients with pancreatic NETs. A strong argument can be made for routine testing.

[Knowuro @knowuro]

✏️
Our 2026 Uro-Oncology Flowcharts are already available free of charge on our website. (https://t.co/J2ExAnFzVY)
Explore our Prostate Cancer Flowchart for a clear and practical overview of diagnosis and management pathways. Thank you, @JGomezRivas, for this great collaboration!

[Oriol Mirallas MD @DrMirallas]

🤯 Outstanding results for #MTAP #KRAS altered pancreatic cancer
✅ ORR 92%
✅ DCR 100%

$TNGX @RevMedicines
@OncoAlert

[The Italian Way of Life @learnitalianpod]

Italian Word of the Day 🇮🇹
💬 Gelataio (jeh-lah-TAH-yoh) - Ice cream maker
📖 Il gelataio del nostro quartiere fa il gelato più buono della città.
👉 The ice cream maker in our neighborhood makes the best gelato in the city.
💡 Traditional gelataios are respected artisans who often create their flavors daily using fresh, local ingredients and family recipes.
Learn it here, then practice daily at ItalianChat (it's FREE to try for 3 days). Link in profile.

[Ashwin Varma, MD @varma_ashwin97]

Did we accidentally discover a synthetic lethal pair lol?

[COR2ED @COR2EDMedEd]

Extrapulmonary neuroendocrine carcinomas (EP-NECs) are aggressive tumours often subject to misdiagnosis and treatment challenges

Understand more about EP-NEC at a glance, with this educational infographic

>> With input from INCA President and CEO of NeuroEndocrine Cancer Australia, Meredith Cummins

Tap image to expand for a better view! 🔍

📜 Download the infographic here: https://t.co/zhkMZtM3eb

Learn more about:

>>> NETs vs. NECs: Key differences in cell differentiation, growth, prognosis, and biomarker expression

>>> Diagnostic Gaps: Overcoming misdiagnosis and specialist access barriers

>>> DLL3 & T Cell Engagers: Visualising the mechanism of action of T cell engagers and DLL3 as a promising novel therapeutic target

>>> Importance of accessing specialist advice and emotional care

This programme has been sponsored by
Boehringer Ingelheim. Brought to you by COR2ED Medical Affairs

#MedEd #OncTwitter #MedTwitter

[Willem Lybaert @WLybaert]

@DrSamuelBHume @Ja_Capdevila The field of pancreascarcinoma seems to accelerate very fast now🥳

[Samuel Hume @DrSamuelBHume]

The RAS revolution continues!

Tango Therapeutics' new results date back to the discovery of a synthetic lethal interaction, in 2016: PRMT5 inhibition selectively kills cancer cells deficient in MTAP — about 40% of pancreatic cancer — while ~sparing normal cells

This mechanism itself is probably independent of RAS, but given RAS inhibition is the likely future foundation of therapy, Tango's PRMT5 inhibitor, Vopimetostat, was tested in combination with RevMed's RAS inhibitor, Daraxonrasib — in MTAP-deficient pancreatic cancer

Today's data come from a small number of patients, but the 6-month progression-free survival was 90% (compared, cross-trial, with Daraxonrasib alone, ~56%)

[Thor Halfdanarson @OncoThor]

Poorly differentiated gynecological neuroendocrine carcinoma is a rare cancer with a dismal prognosis if patients have advanced disease. DLL3-targeted therapy could be an option there but as reported in this study, GYN NECs frequently express DLL3.

https://t.co/bBwnsfzEfR

[Erman Akkus @Erman_Akkus]

GLP-1 receptor agonist use and cancer risk in obese nondiabetic adults - Annals of Oncology @OncoAlert https://t.co/D6xciIzxmD

[Erman Akkus @Erman_Akkus]

📙Renal and hepatic dose adjustment for oncologists

#cancer #oncology #MedX #drug #treatment #therapy #renal #kidney #hepatic #liver @OncoAlert

[Mambo Italiano @mamboitaliano__]

The Atrani Bend 1 – Artificial Intelligence 0

Nothing beats the Amalfi Coast 🇮🇹✨

[Willem Lybaert @WLybaert]

@W0rld2026 Amazing Lake🥰🥰

[WORLD 2026 🌊 @W0rld2026]

Lake como, Italy 🇮🇹

[𝕏 Travels, Hotels and Resorts @em3dia]

🇮🇹 Welcome to Positano, a destination that looks so spectacular it frequently feels like a painting.

This incredible cliffside village tucked along Italy’s sun-drenched Amalfi Coast is world-famous for its unique, vertical cascade of colourful Mediterranean houses that seem to stack effortlessly on top of one another.

Below the houses lie beautiful pebbled beaches, all connected by a labyrinth of steep, winding streets lined with bougainvillaea.

Without question, the views in Positano are truly unbeatable. The architecture is masterfully designed so that almost every vantage point faces the sea. Stepping out onto your private hotel terrace in the morning to take in the sweeping expanse of the deep blue ocean and rugged cliffs is an experience that stays with you long after your holiday ends.

🎥 loloschackman | IG

[Thor Halfdanarson @OncoThor]

Trying to explain somatostatin receptor PET imaging in as few words as possible for my talk at ENDO2026 next weekend... I have found my previous slides to be too wordy (no surprise to anyone who knows me...😅).

How are these for an explanation? My own slide first, then ChatGPT with a prettier slide but I think they complement each other

Nuclear Medicine folks: Feel free to make fun of this... I am just a simple chemotherapist... 🤣

[Erman Akkus @Erman_Akkus]

🏥T4, MRF, CRM in rectal cancer for medical oncologists

✅All related but different concepts
➡️T4b but MRF- (e.g. upper third tm)
➡️MRF by MRI, CRM by pathological
➡️MRF- but CRM+ (e.g. technically hard surgery)

PS: prepared by AI. Surgeon, pathologist, radiologist colleagues may correct if wrong

#cancer #oncology #MedX #rectal #GI @OncoAlert

[OncLive.com @OncLive]

🇪🇺 CHMP has recommended camizestrant plus a CDK4/6 inhibitor for ESR1-mutated HR+/HER2– advanced breast cancer based on data from the phase 3 SERENA-6 trial.

Full details ➡️: https://t.co/m65E4D4JnM

#bcsm #oncology

[BJS @BJSurgery]

Surgical management of small intestinal neuroendocrine tumours
➡️ https://t.co/IB3jb3wXWQ

I TNE dell’intestino tenue richiedono un approccio chirurgico specifico, in grado di conciliare controllo oncologico, preservazione della funzione intestinale, sollievo dei sintomi e qualità di vita a lungo termine
Questa Commission BJS sottolinea l’importanza di una presa in carico multidisciplinare, con expertise nei TNE, e la necessità di strategie più standardizzate e basate sulle evidenze lungo tutto il percorso perioperatorio

Lavoro di Julie Hallet , Massimo Falconi , Sean Bennet , Andrea Frilling , Alexandra Gangi , Sébastien Gaujoux , Rodney Pommier , Emilio Bertani , Gabriela A Buerba , Jennifer Chan , Callisia N Clarke , Sophie Deguelte , Jaydira Del Rivero , Els Nieveen van Dijkum , Teodora Dumitra , Dilmurodjon Eshmuminov , Anton Engelsman , Francesca Fermi , Simona Grozinsky-Glasberg , James R Howe , Angela Lamarca , Léamarie Meloche-Dumas , Frédéric Mercier , Sten Myrehaug , Julie Perinel , Charles De Ponthaud , Ville Sallinen , Yun Song , Heather Stuart , Eva T Janson , Pascale Tinguely , Francesca Tozzi , Tessa van Ginhoven , Susanne Warner , Kjetil Soreide , @spartelli

#SoMe4Surgery #MedTwitter #SurgEd #Surgery @RCPSGTrainees @aecirujanos @SEIQuirurgica @iss_sic #MedicalTechniques @BJSAcademy @young_bjs @BJSOpen @evanscolorectal @robhinchliffe1 @bplwijn @MalinASund @nfmkok @TejedorPat @paulo_sutt @PVaughanShaw @JJEarnshaw @juliomayol @ksoreide #some4UGI #uppergi #esophagealcancer #gastriccancer #reflux @ISDE_net @Augishealth @roux_group @T4UGIS @SARONG_Trial @YoungIFSO #bariatricsurgery