Lucy Yates

Cancer researcher at Wellcome Sanger Institute; Elucidating the nature and clinical relevance of breast cancer heterogeneity & evolution

[Moritz Gerstung @MoritzGerstung]

Interested in spatial biology and cancer evolution?

New spatial genomics technologies start unraveling how somatic evolution, tissue microanatomy and tumour microenvironments interact.

New review with @Yates_lab @LomakinAI and @zaira_sef

https://t.co/O6ejJOypdx

[Lucy Yates @Yates_lab]

@LomakinAI @MatsNilssonLab @MoritzGerstung Honoured to work on this project with such a talented, dedicated and inspirational group of individuals. Check out the figures and https://t.co/m4AxZjWD0T to see where clones actually live!

[Artem Lomakin @LomakinAI]

From sequencing and evolutionary theory we know that tumours grow as mosaics of clones - but so far we haven’t been able to see them.

The labs of @Yates_lab, @MatsNilssonLab and @MoritzGerstung created a new method to map the spatial evolution of cancers: https://t.co/t44QIJ5uY2

[Irshad Lab @IrshadLab_]

Delighted to have our deep dive into understanding the #tumourmicroenvironment of high-risk chemotherapy resistant breast cancers published in @CCR_AACR today!!
@KCLcancer_pharm @ICR_London
@CRUKresearch
https://t.co/LJdn3Ks9ux
https://t.co/aQlpdnvD3G

[Lucy Yates @Yates_lab]

@PapaemmanuilLab Great work Elli, Gunes and team. Fantastic to see what can be achieved in a clinically meaningful timeframe!

[Lucy Yates @Yates_lab]

@ATJCagan Congratulations Alex and team - a fantastic piece of work!

[Lucy Yates @Yates_lab]

@MoritzGerstung @sangerinstitute @emblebi @DKFZ @UniHeidelberg I will certainly miss the coffee shop based science chats! Good luck to you and the family in this exciting new chapter.

[Moritz Gerstung @MoritzGerstung]

What have we learned from analysing 200,000 SARS-CoV-2 genomes from genomic surveillance in England in the last 9 months?

These data provide important context for the current situation related to B.1.617.2.

Here’s a summary of the preprint. https://t.co/V3GCLJy8Ew

[Mike Spencer Chapman @doctor_msc]

1/ How do our bodies – with their incredible complexity - come from a single fertilised egg? How is it co-ordinated? What tissues come from what? Why (and how) might it go wrong? These are the questions we asked in our study out in @nature this week.
https://t.co/XVfHhX9ZLe

[Heather Machado @heatherEmachado]

So proud of this new study. We developed naive and memory B and T single-cell expansion protocols and produced lymphocyte and blood stem cell genomes, from healthy individuals aged 0-81. I am still stunned at the biological insights revealed. [1/10]
https://t.co/8qu19Xue5b

[Inigo Martincorena @imartincorena]

Excited to share our latest work. We present NanoSeq, a new duplex sequencing method with <5 errors per billion sites in single DNA molecules. A leap in our ability to study mutation in any tissue. 1/ https://t.co/QnrbVes3LA

[Vince Buffalo @vsbuffalo]

Alright, since folks are commenting on the Guardian article calling Bayes Theorem "obscure", here's a story about doctors, Bayes Theorem, log scales, and learning and listening from people even when they don't know the thing you know.

[Moritz Gerstung @MoritzGerstung]

These snippets highlight the huge potential of spatial genomics and transcriptomics with BaSISS to study cancer evolution. This will enable us to measure, understand - and hopefully one day prevent - the key steps of malignant progression. 8/9

[Moritz Gerstung @MoritzGerstung]

It's the result of a great research collaboration combining new technology, clinical oncology and data science. Huge thanks to Carina, Milana, @artem_shmatko, Jun, @GenomeDoctor, @stefan_seq, @vitaliikl, Vasyl, Tong, @bayraktar_lab, @luiza_moore, Sarah, Andrea and Peter. 9/9

[Peter Van Loo @VanLooLab]

Proud to present the final chapter of the PCAWG Evolution and Heterogeneity Working Group after 7 years: detailed pan-cancer characterisation of intra-tumour heterogeneity! #PCAWG https://t.co/Q1VFosuO9z

[The Economist @TheEconomist]

People will take enormous risks to enter Britain https://t.co/o4BVJaNeQZ

[Lucy Yates @Yates_lab]

Fantastic paper from the Gerstung lab applies histology based deep learning approach and not only identifies cancer type but also the underlying molecular aberrations.

[bioRxiv @biorxivpreprint]

Pan-cancer computational histopathology reveals mutations, tumor composition and prognosis https://t.co/7Uy0QsrDt1 #bioRxiv

[Luiza Moore @Luiza_Moore]

Our study on normal and cirrhotic liver is also out in @nature. Fantastic work by @sfbrunner led by @Matt_Hoare20 and Peter Campbell @sangerinstitute

Normal liver parenchyma is composed of small clones, but this changes with damage and regeneration in cirrhosis

[Heather McArthur, MD, MPH, FASCO @hmcarthur]

THIs. IS. HUGE!!! A15% improvement in pathological complete response with curative intent pembrolizumab plus chemo in Keynote 522 for #TNBC reported at #ESMO2019

[Eric Topol @EricTopol]

When the #brain is hijacked by #cancer.
It isn't at all pretty as the @nature cover this week
3 reports, summarized well by a @NatureNV by Andres Barria https://t.co/quTFje8LdN and @heidiledford's @NatureNews https://t.co/Hf6VkVg8ef