zerotonone

[BasedBiohacker @BasedBiohacker]

secured enough of the best psilocybin capsules that exist for the rest of the year

capsule form and they always ship fresh batches. Ed goes lengths to make sure we get immaculate quality 🫡

2-3 caps for a solid microdose - very elevated creativity, non-linear thinking, social enjoyment AND enjoyment in work.

it’s my favorite pattern interruptor. details in comments

[baron h. rothschild @HYPER_STITION]

the single most powerful supplement ever is also the cheapest

benfotiamine increases memory so much you can literally remember everything that ever happened in your life

the effects are so strong you will find yourself making new memories by recalling events that you never recalled before

it increases dopamine, motivation, working memory, attention

it increases IQ SIGNIFICANTLY

i won’t get into the psychological effects here, but let’s just say metacognition and agency are a solved science

and the best part? well, there are too many to name…

but one is that there is NO toxicity, meaning you can KEEP TAKING MORE and suffer zero harm

another thing is that thiamine is one of the cheapest supplements on the market

why benfotiamine? i’ve tried all the forms and its the one that i’ve personally felt to be the best

studies also show the same

on rats, benfotiamine, but not fursultiamine, dose dependently increased spatial IQ via maze solving times in rats

the dose these rats were taking was up to 200mg/kg

anyway

if you make money by being able to think, the biggest possible lever you have right now is benfotiamine

uniquely crosses the BBB better than anything else

fat soluble so it stays in the brain and you don’t just piss it out

also has massive effects on strength and motor function, just another bonus

increases metabolic rate

and so on

i could keep going

but i have things to do

benfotiamine

[Mark Kaplan @markkaplan20]

@laumom2 The real risk for heart disease

[Simon Hill MSc, BSc @theproof]

After a scan showed early plaque forming in one of my coronary arteries, I wanted an honest answer to a question I get asked all the time: can a supplement actually reverse plaque, or only slow it down?

In this solo episode I rank eight popular supplements by the strength of the human evidence, from the one with a genuinely strong case to the ones that are all hype, including a fact-check of a claim you have probably seen online.

For the full show notes head to: https://t.co/YAJFJjcTyT

[Craig Brockie @CraigBrockie]

I've tested hundreds of supplements over 30 years to heal myself.

Most are worthless, but these 15 transformed my health.

At 50, my bloodwork is better than when I was 20.

The evidence-based supplement list that actually works: 🧵

[Avid @Av1dlive]

You can build an AI second brain in 15 minutes.

No coding experience needed. no $1000 course

[Here is how you can do it in 5 mins:]

Step 1: Download Claude Desktop.

Step 2: Download Obsidian Desktop.

Step 3: Create a new vault and start dropping .MD files into it.

Step 4: Tell Claude Code to connect directly to your vault using Andrej Karpathy's prompt: https://t.co/2SJBZyjXDl

That is it.

Your entire knowledge base becomes searchable, connectable, and queryable by the most powerful AI model on earth.

Every note you have ever written.

Every idea you have ever captured.

Every resource you have ever saved.

Claude can now read all of it, find connections you missed, and surface insights from your own thinking that you forgot you had.

Most people are using Claude as a search engine.

The people building second brains with it are using it as an intelligence layer on top of everything they know.

The gap between those two use cases is the gap between asking Google a question and having a research partner who has read everything you have ever written.

Bookmark this.

Build it tonight.

[Khairallah AL-Awady @eng_khairallah1]

this is f*cking gold

A senior Google engineer dropped a 424-page doc on agentic design patterns.

424 pages.

Most engineers bookmarked it and never opened it again.

if I had this a year ago, I would've shipped my first app in a day instead of 2 weeks

in the right hands, this changes everything:

[Afshine Emrani MD FACC @afshineemrani]

I'm a cardiologist. After 40, stop guessing about your health. These numbers tell you whether you're building a long, vibrant life — or quietly declining without knowing it.

I run these on myself. I run them on every patient I care about. Most are cheap bloodwork. All are available now. And together, they paint a picture no standard annual physical will ever give you. Print this. Bring it to your next appointment. Your 60-year-old self will thank you.
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𝗙𝗮𝘀𝘁𝗶𝗻𝗴 𝗜𝗻𝘀𝘂𝗹𝗶𝗻
Target: below 5 μIU/mL. Ideal: 3-4.
This is the 10-year warning bell your standard panel completely misses. Your glucose and A1c can look "normal" for a decade while your pancreas is working overtime to keep them there. Fasting insulin catches insulin resistance 5-10 years before your A1c moves. By the time A1c rises, the damage is already extensive.

𝗛𝗢𝗠𝗔-𝗜𝗥
Target: below 1.0.
Calculated from fasting insulin and fasting glucose. The single best measure of insulin sensitivity. Above 1.0 and your metabolism is already under strain. Above 2.5 and you're insulin resistant — even if every other number looks fine.

𝗛𝗯𝗔𝟭𝗰
Target: below 5.4%.
Not below 5.7% — that's the threshold where medicine calls you "prediabetic." By then you've been metabolically compromised for years. Optimal is below 5.4%. Blood sugar mastery is longevity mastery.

𝗧𝗿𝗶𝗴𝗹𝘆𝗰𝗲𝗿𝗶𝗱𝗲 : 𝗛𝗗𝗟 𝗥𝗮𝘁𝗶𝗼
Target: below 2. Ideal: below 1.
Your metabolic health crystal ball. This ratio predicts insulin resistance, cardiovascular risk, and metabolic syndrome better than any single lipid number alone. A ratio above 3.5 is a red flag regardless of what your total cholesterol says.

𝗔𝗽𝗼𝗕
Target: below 80 mg/dL for moderate risk. Below 60 for high risk.
I've written about this extensively. ApoB counts every atherogenic particle hitting your artery walls. A 2024 analysis found 54% of patients had dangerous levels that standard LDL testing completely missed. If you only know your LDL, you're driving with one eye closed.

𝗟𝗽(𝗮)
Test once in your lifetime.
100% genetic. 1 in 5 Americans are elevated. Triples heart attack risk independently of everything else on this list. Diet and exercise cannot lower it. The 2026 ACC/AHA guidelines now recommend everyone be tested. Most never have been.

𝗵𝘀-𝗖𝗥𝗣
Target: below 1.0 mg/L.
You can have perfect cholesterol and inflamed arteries silently preparing to rupture. hs-CRP measures the fire behind the plaque. The JUPITER trial proved that finding and treating inflammation saves lives — even when lipids look fine. If this number is elevated, your mouth, your gut, your metabolic health, and your visceral fat are the first places to investigate.

𝗩𝗶𝘁𝗮𝗺𝗶𝗻 𝗗
Target: 50-80 ng/mL.
Not the bare minimum of 30 your doctor accepts. Suboptimal vitamin D is linked to higher inflammation, weaker immunity, increased cardiovascular events, worse mood, and poorer outcomes across nearly every disease I treat. Supplement D3 with K2 — without K2, calcium deposits in your arteries instead of your bones.

𝗧𝗲𝘀𝘁𝗼𝘀𝘁𝗲𝗿𝗼𝗻𝗲 (𝗧𝗼𝘁𝗮𝗹 + 𝗙𝗿𝗲𝗲)
Men: optimal range 600-1000+ ng/dL total.
Declining testosterone is an independent predictor of cardiovascular death in men. It's tied to insulin resistance, arterial stiffness, visceral fat accumulation, and systemic inflammation. DHEA-S drops 10-20% every decade after 30. Tracking these isn't about vanity — it's evaluating your body's systemic resilience.

𝗕𝗹𝗼𝗼𝗱 𝗣𝗿𝗲𝘀𝘀𝘂𝗿𝗲
Target: below 120/80. Aim closer to 110/70.
Every point above optimal is cumulative arterial damage. Buy a home cuff. Measure morning and evening, seated quietly for five minutes, arm at heart level. White-coat readings in the office miss what's really happening. The smartest $40 investment in cardiac self-care.

𝗩𝗢𝟮 𝗠𝗮𝘅
Men over 40: above 40 mL/kg/min. Women over 40: above 35.
Cardiorespiratory fitness is the single strongest predictor of all-cause mortality — stronger than smoking, diabetes, or heart disease as individual risk factors. A landmark study in JAMA found that extreme fitness was associated with the lowest mortality with no upper limit of benefit. You can estimate VO2 max with a timed mile, a rower test, or a wearable. Get faster every year.

��𝘂𝗺𝗯𝗲𝗿 𝗼𝗳 𝗠𝗲𝗱𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀
Target: as few as possible.
Every medication you're on should be earning its place. I just wrote about five commonly prescribed drugs that do more harm than good with long-term use. Bring your full medication list to every appointment. Ask: "Do I still need this?" Deprescribing is one of the most powerful and underused tools in medicine.
ꟷꟷꟷ

Thirteen numbers. Most available through cheap bloodwork and simple tests. Get them once or twice a year. Here's what I want you to understand: these numbers don't just tell you where you are. They tell you where you're heading. A fasting insulin of 8 today becomes diabetes in five years. An ApoB of 120 today becomes a heart attack in ten. An hs-CRP of 3 today means your arteries are inflamed right now — regardless of how healthy you feel. The standard annual physical checks a fraction of these. It was designed to find disease that's already there. This panel finds the disease that's coming — years before it arrives.

What gets measured gets improved. Optimize with the foundation I write about every week on this platform:
Zone 2 cardio plus resistance training 3-4 times per week. High-protein whole-food nutrition. Sleep 7-9 hours — non-negotiable. Morning sunlight. Stress management. And the targeted supplements I've covered in detail — creatine, magnesium, CoQ10, D3+K2, glycine, omega-3, psyllium husk.
The breakthroughs coming in the next decade — gene editing for cholesterol, cellular reprogramming, senolytics that clear senescent "zombie" cells driving inflammation and aging, GLP-1 drugs rewriting metabolic medicine — will be most powerful for people who've already built the metabolic foundation to receive them.

The future of medicine is personalized. But it starts with knowing your numbers today. Print this list. Book the bloodwork. Own the data. Prevention isn't passive. It's the most aggressive thing you can do for the decades ahead.

[ゆな @nursahbazx]

Xで最も検索してはいけないアカウント
1位: 0no_a00

2位: R_Kundesu888

3位: aagde4

4位: vqde66

5位: 63wlz

6位: rnqco_t

7位: pisudayo194514

[ZIP🇹🇿 @zipdmpjr26]

Top Netflix Series with Steamy & Porn Vibes (TV-MA)

Netflix isn’t full porn, but these have tons of explicit sex scenes, nudity & hot moments:

Thread 👇👇👇👇👇

[Elon Musk @elonmusk]

The standard applied by DOGE was very simple and easy:

Provide contact information for the recipients of aid, so that we can confirm it is not fraudulent.

The reality is that money was being sent to corrupt politicians under the guise of aid! Liars and stock insider traders like Ro the Robber should be in prison!!

[Chioma Amadi @Chioma__Amadi]

If you’re hunting for a remote job, you just need to figure out how Reddit works, and you’ll never be unemployed for a long time.

Here’s a list of subreddits you should bookmark right now:

[BasedBiohacker @BasedBiohacker]

everyday 100 people tell me about their problems and ask for a solution.

99% of the time, it goes like this:

i get brain fog and feel tired all the time
- 500mcg oral BPC-157, 1 drop vitamin E, B1 TTFD, 500mg ALCAR, 200mg CoQ10
- your gut and metabolism is nuked. stop eating like shit, have some kefir in the morning, and avoid stress as well as you can.

i can't focus, i get distracted
- 200mg modafinil, 100mg bromantane
- make a to-do list, put your phone in a kitchen drawer and don't get up until you're done.

i sleep like shit, how do i fix it
- 80mg silexan, 1mg pinealon, 3mg epitalon, 5g glycine, 144mg magnesium l-threonate, topical magnesium
- avoid blue light after the sun goes down, read before sleep.

my brain is fucked after substance/alcohol abuse, how do i get it back?
- 5mg dihexa, 14 days of 1 ampoule cerebrolysin, 2mg pinealon, 100mg bromantane
- read my article "brain rehabilitation beyond conventional medicine" to understand this deeper and tailor it to your situation.

i have an annoying injury that won't go away
- localized BPC-157 injection. or KLOW.
- inject once or twice a day until the injury is healed/ max 45 days.

obviously it's not always this easy... but it often isn't much more complicated to get real, tangible results you can feel on day one or within a few days by applying the right compound to the right situation.

you can learn more about all of these here: https://t.co/hI1Nt0PffZ

[Ridark @ridark_eth]

I genuinely don't understand why everyone isn't using this yet

Andrej Karpathy, a co-founder of OpenAI, posted a simple idea that hit 16 million views: stop using AI to write code, use it to build a second brain.

You point Claude Code at a folder, drop in any source, an article, a transcript, a PDF, and Claude reads it, links it, and files it into a living wiki of everything you know. It compounds like interest, the more you feed it, the smarter it gets.

Here's the whole thing:

> Install Obsidian, create a vault, open it in Claude Code

> Paste Karpathy's wiki idea file and tell Claude to build it

> Claude makes three folders: raw for sources, wiki for its pages, a CLAUDE.md that runs it

> Drop any source into raw and say "ingest this"

> Ask questions across everything, forever

Five minutes to set up, and you never start from a blank chat again.

Full step-by-step guide with Claude and Obsidian, link below.

Bookmark this

[Michael Morelli @morellifit]

I see a lot of guys 35+ on X spending thousands on peptides…

But nobody told them to check:
→ fasting insulin
→ ApoB
→ hs-CRP
→ fasting glucose
→ blood pressure
→ liver enzymes
→ kidney markers

They’re chasing optimization while their fundamentals are quietly getting worse.

Here’s the support system I personally use to keep my body in a place where performance can actually happen:

• insulin sensitivity
• cardiovascular health
• liver support
• kidney support
• recovery
• long-term performance

Daily foundation:
→ Creatine (strength + performance)
→ Magnesium glycinate (sleep + recovery)
→ Omega-3s (lipids + inflammation support)
→ Vitamin D3 + K2 (if labs support it)
→ Electrolytes (hydration + performance)
→ Fiber + whole foods first
→ Protein target daily
→ Walking after meals
→ Resistance training
→ Sleep

Then supplements become leverage.

Next peptides become leverage.

Finally advanced therapies make sense.

Not before.

Performance healthcare doesn’t mean inject more.

It’s…building a body that responds.

Your stack means nothing if your biomarkers are getting worse.

[Greg O'Gallagher @gregogallagher]

Ozempic was never designed to make you lean.

It was built for type 2 diabetes. GLP-1 is a signal your gut sends after you eat. It tells the pancreas to release insulin. It calms glucagon. And blood sugar improves.

Then researchers noticed something they weren’t looking for.

The patients were losing weight. They ate less. They got leaner. Not through willpower. Through improved satiety.

So it was studied for weight loss. And approved for it.

Then came the next layer. Tirzepatide. They added a second signal, GIP, to improve tolerability and insulin sensitivity. And in the trials, something fascinating showed up.

The improvements seemed to start before the weight came off. Markers of metabolic health moved early. Inflammation markers came down. The benefit didn’t appear to be just from weight loss alone.

Now researchers are asking the bigger question. Why does steady GLP-1 and GIP signaling seem to create broad band health benefits

[CyrilXBT @cyrilXBT]

140K GitHub stars. Three months.

Most people still copy-pasting into ChatGPT every morning.

Hermes plus Obsidian plus NotebookLM equals a second brain that compounds forever.

Writes its own skills. Maps its own knowledge. Remembers everything you taught it.

One setup. Runs locally. Never starts from zero again.

Save this before you explain yourself to an AI one more time.

Bookmark this now.

[BasedBiohacker @BasedBiohacker]

modawhale just dropped ivermectin in the EU and US

curious to hear how people have been using it

the internet has been kind of quiet about it lately

[Morty @0xMortyx]

Andrej Karpathy in 1 hour reveal how he actually works with AI: "i just tell the machine what i want, in plain words"

no prompt frameworks. no 40-line system prompts. no magic.

by 2026 the engineer who dismisses LLMs loses to the junior who configured one right

1 hour. free. the most honest look at how the best in the world actually uses AI

bookmark & watch

[Rahul @sairahul1]

Claude Code's creator said something that stopped me cold:

"I don't prompt Claude anymore. I write loops — and the loops do the work. My job is to write loops."

Most developers are still crafting the perfect prompt.

The person who built the tool moved past prompting entirely.

In 30 minutes Boris reveals his actual daily Claude Code setup.

Claude Code + loops + dynamic workflows.

Worth more than any $500 vibe-coding course.

Watch it.

Then read this - everything you need to know about loops to actually apply what he says ↓

Bookmark both. This is your weekend.