At 37 Patrick Collison listed the reason not to start a company in every decade since the 80s.
Japan will win everything, Microsoft will dominate, the dotcom crash, Google, then Facebook, now the AI labs:
Every single time it was empirically a great time to start a company.
He arrived in Silicon Valley in 2010 and people were already saying the funding was drying up.
For more than a generation, betting on entrepreneurship has been a durable bet.
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At 42 Mark Zuckerberg put cameras in his gym so an AI can coach him in MMA between rounds.
He has 60 seconds between rounds and the AI took 30 to answer, so he told it to optimize itself:
The agent writes an entire video processing pipeline and he never sees a line of code.
It tells him about hip position and the underhook he missed in side control.
His prediction is that everyone will soon be writing tons of code without knowing it.
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In 2025 Zuckerberg was poaching OpenAI researchers with nine figure offers and Sam Altman had three words.
"So, bring it":
He says winning is fun and he expects to win.
Then he shares the best mental shift of his life, learning to love the hard parts.
Someday he will be retired on a ranch missing the drama, so he decided to be grateful for it now.
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In 2023 Mark Cuban put his own name on a company for the first time in his life, to sell drugs.
Cost Plus Drugs shows you its cost, adds 15%, and that is the price:
A cancer drug that CVS charges $2,000 for costs $61.
A paralyzed friend was quoted $110,000 every three months, Cost Plus charges $51.
Shkreli raised a price 100 times in a day, Cuban says that proved you can cut it just as fast.
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In 2023 Mark Cuban read Twitter's open source algorithm and found the problem, Elon himself.
160 million followers plus an algorithm that amplifies the biggest users and everyone they reply to:
When Elon writes "interesting" under a crazy post, that post goes everywhere.
His fix is for Elon to remove himself from the algorithm, and he told him so.
He also suspects abandoned 2015 accounts are being turned into bots to pump user numbers.
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In 2025 Sam Altman said his son will never be smarter than an AI, not for one day of his life.
Kids born a few years earlier had a brief window, his never will:
He only went to half of college and does not expect his kid to go at all.
The baby in the dentist's office treating a magazine like a broken iPad is the whole story.
In 18 years education will look like a very, very different thing.
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