Angela sharp

[Dr. Sean Mullen @drseanmullen]

In 2020, my concern was infection and death.

By early 2021, after reading everything I could get my hands on, talking with infected individuals, and seeing changes emerge in cognitive screenings from my own lab, I realized we were dealing with something much bigger.

I’d tell my students, almost matter-of-factly, “Covid causes brain damage.” They’d look at me like I was Tom Hanks having a conversation with Wilson in Cast Away.

Years later, what’s hardest isn’t being right. It’s realizing how much of this could have been prevented…and how many people never had the chance.

[Zdenek Vrozina @ZdenekVrozina]

A German study followed 74 children and teens with severe long COVID for up to 3 years after infection, measuring their immune systems repeatedly. The finding worth unpacking - that immune picture kept shifting over time. It wasn't frozen in place.🧵

[Bocquet Annelise 🔬🧬📚🚜 @AnneliseBocquet]

Hé ben... ouaip...
Le COVID - surtout sévère - peut accélérer le vieillissement cérébral. C’est comparable à la vague de parkinsonisme post-1918.

Il faut savoir que... Après la pandémie de grippe espagnole (1918-1920), on a observé une augmentation très nette de cas de parkinsonisme (symptômes ressemblant à la maladie de Parkinson : tremblements, rigidité, troubles de la marche) chez des personnes ayant eu la grippe, parfois des années plus tard.

Ce n’était pas la maladie de Parkinson "classique" (dégénérescence idiopathique lente), mais une forme post-infectieuse (appelée encéphalite léthargique ou parkinsonisme post-encéphalitique). Elle touchait surtout les ganglions de la base (notamment le noyau caudé et le substantia nigra), avec une composante inflammatoire et possiblement auto-immune.

C’est l’un des exemples historiques les plus clairs d’un virus respiratoire neurotropique qui laisse des séquelles neurologiques à long terme, parfois des décennies après l’infection aiguë.
https://t.co/scpTUQahqa

Ici, dans le cadre du SARS-CoV-2, c'est une étude génétique qui renforce l’idée que le COVID laisse des traces neurologiques durables, notamment via des mécanismes inflammatoires et protéiques (amyloïdes/prion-like) dans des zones comme le noyau caudé.
https://t.co/b07MlwQJ2C

Cette zone, le noyau caudé (caudate, dans les ganglions de la base), ressort particulièrement touchée, même dans les formes légères selon d’autres études. Et... c'est la même zone impliquée dans la maladie de Parkinson, les symptômes prodromaux du covid-long, l’agrégation d’α-synucléine et l’inflammation des monocytes.

Il me semble que j'ai averti pour les vagues neurodégénératives à venir... hum...
https://t.co/YQGltnxjuc
https://t.co/MGjIfA3IGV
L’élévation des NfL dans les covid-longs (comme mentionné dans les threads ci-dessus) est cohérente avec un processus encéphalitique subaigu ou une neurodégénérescence post-virale de type parkinsonien. C’est un marqueur non spécifique de dommage neuronal, mais très utile pour suivre l’évolution.

Je sais que mon vocabulaire et mes méthodes ne sont pas très académiques. Mais je sais encore de quoi je parle... on a perdu du temps... beaucoup de temps. Pour diverses raisons... mais on me met beaucoup de bâtons dans les roues. Cela, c'est une certitude.

[Governor Tim Walz @GovTimWalz]

America’s real state fair starts August 27th. Plan accordingly and thank you for your attention to this matter.

[Zdenek Vrozina @ZdenekVrozina]

And public health treated prevention as optional. No clean air mandate, mild reframed as fine, reinfection normalized. If this signal holds, we will have run an uncontrolled neurodegeneration experiment on the whole population and called it returning to normal.

[Mike Levin @MikeLevin]

Let me tell you what just got reported, because you will not believe it until you see it laid out.

The Trump administration cut a billion-dollar tungsten deal with Kazakhstan. Tungsten is the metal we need for missile warheads, fighter jets, and computer chips. Trump himself got on the phone to close it. Commerce Secretary Howard Lutnick worked it from the inside, sending letters, leaning on the Kazakh president, lining up as much as $1.6 billion in federal financing.

Within weeks of those negotiations, investors tied to a firm partly owned by Donald Trump Jr. and Eric Trump took a 20% stake in an entity connected to the very same Kazakhstan project their father was negotiating. Around that same time, Cantor Fitzgerald, the firm run by Lutnick’s own sons, raised $210 million for a partner in the deal and pocketed the fees.

The fathers set the policy. The sons cashed in.

Six days after the Trump sons and their partners moved their money, Lutnick signed the final deal.

The reporting found one or both families have financial ties to at least 14 companies working with the government on critical mining deals.

The total federal funding flowing toward those companies tops $8.9 billion.

This is your tax money.

It is supposed to secure our supply chains and protect our troops, not pad the portfolios of the President’s children and the Commerce Secretary’s children.

This is the most corrupt administration in American history. It is not close.

We must keep digging, and keep asking the questions they do not want asked. Republicans in Congress are unwilling to lift a finger. Mike Johnson is running a protection racket.

Either we will end the corruption, or the corruption will be the end of us.

https://t.co/yFOl7zvOhC

[Angela sharp @1MNgardener]

@drseanmullen Exactly this. I never fully realized how self absorbed humans could be or felt so much disgust.

[Dr. Jennifer Irwin @drjenirwin]

Long-term neurological & cognitive impact of COVID-19: systematic review & meta-analysis in over 4 million patients

Findings included:
fatigue 43.3%
memory disorders 27.8%
cognitive impairment 27.1%
sleep disorders 24.4%
concentration impairment 23.8% https://t.co/Mldydwj5M3

[Tim Walz @Tim_Walz]

Found an imaginary problem, said only they could fix it, didn’t listen to experts, hired buddies who grifted millions, failed miserably, bragged how great it went.

The entire Trump presidency in a nutshell.

[Barack Obama @BarackObama]

To George and Laura, Bill and Hillary — we're grateful for your friendship, counsel, and devotion to this country. And to Joe and Jill, thank you for being on this journey with us.

[Amy Klobuchar @amyklobuchar]

With $300 billion, we could end homelessness, fund cancer research for 40 years, and give every child free pre-K for over 7 years. Instead, Trump is sending it to Iran. This is not America First. Not even close.

[Rep. Dr. Jasmine Clark @jasmineforga]

When I head to Washington, I will be the first woman in Congress with a science PhD. That matters. At a time when science is under attack, Congress needs more leaders who understand the value of evidence-based decision-making.

[Bill Kristol @BillKristol]

So the ballroom is a fiasco, the reflecting pool is a fiasco, the Iran war is a fiasco—the Trump administration is a fiasco.

Thank you for your attention to this matter.

[Vipin M. Vashishtha @vipintukur]

#LongCOVID may leave a visible metabolic fingerprint in the brain—years after the initial infection.

➡️ Using 18F-FDG PET-CT, researchers found persistent areas of reduced brain glucose metabolism (hypometabolism) in Long COVID patients, particularly those suffering from fatigue and post-exertional malaise (PEM). 1/

[AJ Leonardi, MBBS, PhD, MPH @fitterhappierAJ]

I was a fellow at the National Cancer Institute for 4 years in immunotherapy of cancer

They paid for my PhD

I am happy to explain hypotheses for a potential SARS Cov 2 based increased risk of cancer:

1/4

[Dr. Jennifer Irwin @drjenirwin]

The “please be kind to those who choose to wear a mask” directives feel like a special kind of gaslighting.

Instead, how about: “please consider thanking every masked person you see for their evidence-based & respectful decision to help keep themselves and you safe.”

[Dr. Sean Mullen @drseanmullen]

In academia and industry, indoor air quality has largely been driven by an HVAC-first mindset. Most innovation focuses on optimizing building performance, energy efficiency, occupant comfort, and increasingly, AI-driven monitoring systems that adjust conditions room by room.

Technologies like UV disinfection are beginning to gain traction, but adoption remains relatively limited and is often confined to specialized applications such as upper-room systems and in-duct treatment.

What surprises me is how little urgency exists around indoor air as a public health intervention. We monitor food safety, water quality, and countless environmental hazards, yet the air we share indoors receives comparatively little attention despite its implications for respiratory infections, chronic disease, productivity, and quality of life.

Part of the challenge may be that air quality improvements compete for attention in a world filled with economic uncertainty, political conflict, public health fatigue, budget cuts, and competing priorities. When people are worried about paying bills, geopolitical instability, or the next crisis in the news cycle, clean air often feels abstract and invisible (actually…it’s almost always invisible unless you live in an area where you can see air pollution).

Yet that invisibility is exactly the problem. Air quality influences health whether we think about it or not. Everyone would say that indoor air matters…it’s just that we’re not willing to invest in prevention before the consequences become impossible to ignore.. Even the freakin air experts are flying on baseless assumptions, faulty reasoning and they all seem to have a really bad memory.

[Jo @JoJoFromJerz]

How the fuck do we have $300 billion to rebuild Iran after we spent $80 billion bombing it, when we don’t “have the money” for pediatric cancer research?

[Harry Spoelstra @HarrySpoelstra]

The long-term cardiovascular risks of SARSCoV2 infection and reinfections

Your heart is under silent, cumulative attack from SARSCoV2, and every reinfection can reload/worsen the damage.

Here a personal recap of 10 important studies from the last 2 years showing exactly how this virus and its reinfections can/may shape (and shorten) your cardiovascular future.

Evidence is clear, long-term, and growing.

Print and show your Cardiologist.

Let’s connect the dots…

1. Immunothrombosis multi-omics study:
3 months after hospitalisation, long COVID patients still have blood biologically “clot-ready” with persistent endothelial activation and prothrombotic signalling.
https://t.co/9yj7zVbgxO

2. IL-6 & SAA 6-year study:
Higher acute-phase IL-6 and SAA levels independently predict cardiovascular events and death up to 6 years later, the initial inflammatory storm leaves a lasting CV mark.
https://t.co/Vk7FvK9fQc

3. MIS-C long-term outcomes:
Up to 4.5 years later, MIS-C raises cardiovascular disease risk 14× and hypertension 9× in children, with risks still accumulating.
https://t.co/itRENsOlOS

4. Viruses & cardiac disease review:
SARS-CoV-2 stands out for direct cardiomyocyte invasion + explosive damage + relentless accumulation of risk with every reinfection.
https://t.co/fOX07JNW2o

5. Mayo PET long COVID study:
Persistent cerebral hypometabolism in fatigue/PEM patients still detectable up to 2 years post-infection.
https://t.co/puvllNfghC

6. Reinfection CV outcomes summary:
Reinfections worsen cumulative heart damage, arrhythmias, thrombosis, stroke risk and long COVID cardiovascular symptoms.
https://t.co/B3q7DzyxCZ

7. Youth reinfection & long COVID study:
Reinfection roughly doubles PASC risk, with myocarditis up to 3.6× higher, heart disease ~2× higher and increased thromboembolism.
https://t.co/aqN3VV0kMX

8. Mild infection + reinfection risk:
Even mild cases trigger lasting endothelial damage and prothrombotic state (1.5–2× long-term CV risk), each reinfection compounds the burden.
https://t.co/SvPzOBSOx1

9 Mitochondrial dysfunction in long COVID:
Persistent mitochondrial dysfunction and suppressed oxidative phosphorylation remain in long COVID, pointing to durable multi-organ impact.
https://t.co/98MbV19R9r

10. Cumulative reinfection impact on future CV health:
Reinfection stacks additional damage on prior endothelial injury and inflammation, increasing lifetime risk of heart failure, arrhythmias, thrombosis and accelerated cardiovascular disease.
https://t.co/aqN3VV0kMX

11. Extra, my earlier general reminder post on this exact theme: https://t.co/o3QT12nIG4

‼️Overall convergence across the studies:
Immunothrombosis, acute inflammation markers, direct invasion, endothelial damage, and mitochondrial issues create lasting CV vulnerability that reinfections can keep reloading. #L0ngC0vid

The pattern is very clear.

Fewer infections = lower lifetime cardiovascular risk.

You only have one heart.

Protect it!
#AvoidSars2 #AvoidReinfections #CleanAir #VaccineUpdated

[Bluebird pooped an X @bluebirdpoopies]

This is not residual algae. This is not sabotage. This is not sea monkeys. This is not going away. This is the result of incompetence and creating a heat sink in a shallow non chlorinated pool.