Alfonso Felipe

[Alfonso Felipe @ALFONFX]

@e_dampier @MGF30120499 @Brandon_Beaber My PPMS has progressed significantly, but please stop it for all those future 27-year’s olds like I was, knowing something is not OK.

[Alfonso Felipe @ALFONFX]

@Brandon_Beaber All pediatric MS is RRMS, right? Makes sense… good news!!

[Alfonso Felipe @ALFONFX]

@GS1_US I emailed, issue resolved. Thanks! 😊

[Alfonso Felipe @ALFONFX]

@GS1_US i'm trying to create a ticket to get support, but my portal says 'access denied'. How can I get help?

[Alfonso Felipe @ALFONFX]

@Brandon_Beaber So tired of this… as if MRI could show what really happens in MS. None of these DMTs target underlying neurodegeneration, the real MS. 🤦🏻

[Alfonso Felipe @ALFONFX]

@Brandon_Beaber I agree with you: “profound effect” is what they want to project to lure investment.

[Alfonso Felipe @ALFONFX]

@Brandon_Beaber It is the same target of eque-cel (CT103A), a drug cleared by the FDA to start trials in MS: https://t.co/tWYMQzhNN5

[Alfonso Felipe @ALFONFX]

@Brandon_Beaber can we trial this in a phase III in pMS?
https://t.co/QFmWl780WI

[Alfonso Felipe @ALFONFX]

@KiranDhamale77 @Brandon_Beaber As a rapidly-evolving PPMS patient, listening about ‘benign MS’ seems incredible

[Alfonso Felipe @ALFONFX]

@RachelHorne19 @Brandon_Beaber I am now hopeful for anti-BCMA CAR-T cell therapy, given the meh results of BTKs. Hope I get to see some good results in the future !!

[Alfonso Felipe @ALFONFX]

https://t.co/tg9hxrbc3T

[Alfonso Felipe @ALFONFX]

@Brandon_Beaber Any info on PPMS? Why is this rarely prescribed?

[Alfonso Felipe @ALFONFX]

@Brandon_Beaber I usually assume rapidly-evolving, young PPMS is the “worst” in the MS spectrum, in relation to disability accrual. Not always, apparently.

[Alfonso Felipe @ALFONFX]

@Brandon_Beaber Guess the argument “pMS is the real MS” is true after all

[Alfonso Felipe @ALFONFX]

@Brandon_Beaber I’d agree. I was d’xed with PPMS, haven’t got a single relapse. PIRA has been brutal since 2024, despite Ocrevus since 2019.

[Alfonso Felipe @ALFONFX]

@Brandon_Beaber

[Alfonso Felipe @ALFONFX]

Majestic in defeat, defiant in silence — you’re not done yet.

[Alfonso Felipe @ALFONFX]

@Brandon_Beaber For inactive, young PPMS, that doesn’t seem to be the case 😣. So sad & scary to be on this side of the spectrum…

[Alfonso Felipe @ALFONFX]

@Brandon_Beaber Wish all my academic achievements would save me from my rapidly evolving, non- active, young-onset PPMS, now going EDSS > 6. Good that when I was younger I was blissfully unaware of what would come 🤪

[Alfonso Felipe @ALFONFX]

@SpringerIME CAR-T cell therapies for B-cell malignancies should be studied in progressive multiple sclerosis also.