Alex Predeus 🇺🇦

Moscow State - Michigan State - WashU Pathology & Immunology - Bioinformatics Institute SPb - University of Liverpool - Wellcome Sanger Institute

[Caroline Watson @carolinewatson]

How does leukaemia develop? 🩸 How long does it take? ⏳

🌟 Our paper, started back when I was a PhD student in @jrblundell’s lab, is out today in @Nature 🌟

Yearly blood samples from women who developed AML in later life let us trace it back decades 👇
https://t.co/fqyOpc5OKH

[Alex Predeus 🇺🇦 @APredeus]

@squidian истерика! впрочем, не поменял на серп и молот, и то хлеб

[Alex Predeus 🇺🇦 @APredeus]

@komposterov В Португалии недавно уличный трамвайчик свалился катастрофически, человек 40 угробил

[Alex Predeus 🇺🇦 @APredeus]

@joerees75395391 @molecularpepsi @Nature @mbeisen That's an amazing way to spell that word, if I guessed the word correctly

[Alex Predeus 🇺🇦 @APredeus]

@javid_lab @NikoMcCarty Pretty much everybody knows it's not really simple and elegant. The cool trick that many "experimentum crucis" approaches use though, is to find a point of view, from which a certain aspect of it becomes simple and elegant.

[Aleksejs Sazonovs @alehins]

We would like to become a guest-editor on the latest issue of Frontiers Genomics

[jon drake @DrakeGatsby]

“In situations like this” what the fuck are you talking about. Are you Wile E Coyote

[𝓟𝓮𝓷𝓰 𝓗𝓮 何鵬 @PengHeAtlas]

1/8 What remains undiscovered in the human kidney? 🔍

While building an integrated human kidney atlas for the Human Cell Atlas, we discovered new biology—presented in our new preprint, with highlights below. 🧵

https://t.co/Z1veUKiFqS

[Alex Predeus 🇺🇦 @APredeus]

@komposterov

[Maxim Artyomov @maxim_artyomov]

Out today in Immunity! Our pan-atlas of human immune aging: 12.4 million PBMCs from 2,609 people across 8 global cohorts (including new 188 people cohort from UK).
https://t.co/hYbe2k3XEi
We map shared aging patterns onto 59 key immune populations and link the balance of GZMK+ and GZMB+ CD8 effector memory T cells to health trajectories; show differences in RTEs and Th2s with sex etc; ethnicity associated features.

https://t.co/AHmFVQVfM6

How it came to be:
in 2023 we published first hierarchically annotatied atlas of human immune aging in PBMC - 166 people, 55 populations, key changes revealed - CD8 naives, KLRC2/NKG2C+ CD8 memory going down, GZMK+ CD8 T cells and Th2 and Tc2 type 2 memory cells going up! (Terekhova et al, Immunity 2023)

in 2024 we added major phenotypes within naive cells - SOX4+ RTE cells and their CD38 marker going down. (Bohacova et al, Immunity 2024)

In 2025-26 more atlases published with their own annotations making impossible to leverage power of data..

Now we provide unique in its power and consistency resource - 2600 people across ages, sexes, races, continents etc. All annotated in sync and analyzed for what aging looks like globally!

[Alex Predeus 🇺🇦 @APredeus]

@xanaxagor @lpachter well, I guess it depends on how complex of a thing you mean? if you can see every outcome of the game, you stop enjoying it.

[Alex Predeus 🇺🇦 @APredeus]

@xanaxagor @lpachter I don't think its solved in a conventional sense, the number of possible combinations is too large

[Alex Predeus 🇺🇦 @APredeus]

@e_dampier @baym Who says it's 6-10 years away? Vaccines against herpesviruses are among the hardest things to create. So far any timeline seems pretty much meaningless

[Sri Kosuri @srikosuri]

This is fun.
1. Mango Banana - banana on the outside, mango on the inside. Enough said.
2. Plant machine interfaces - we should be able to trade plants N,P,H2O for reduced carbon compounds. Do to them what they did to chloroplasts
3. Solution phase self assembly of 3D memory chips using designed self-assembly of macromolecules - do we really get protein design
4. A brain the size of a building. - what would it be thinking?
5. A five assed monkey - bc South Park
6. Self growing housing - the rent is too damn high
7. Obviously brain machine interfaces - I will judge this by when I can browse the web by thinking about it.
8. Dinosaurs.
9. Cats with dog personalities.
10. A nice smelling microbiome

[Sam Sinai @samsinai]

Anthropic: We are going to relax the Claude safe guards, act responsibly, it can be used to make bioweapons.

Biologists:

[Jaime @izurietavarea]

Meanwhile, at the Federal Reserve Bank of New York

[Alex Predeus 🇺🇦 @APredeus]

@StevenSalzberg1 so, to put it short, you don't believe in GWAS? that's pretty wild. Don't you think it merits an editorial? Do you also not believe in RVAS?

[Alex Predeus 🇺🇦 @APredeus]

@StevenSalzberg1 RSS might be an unfortunate acronym - there's a recombination signal sequence (RSS) in VDJ recombination. General similarity of context would make it hard to distinguish the two in searches, AI-based analysis, etc.

[Alex Predeus 🇺🇦 @APredeus]

@Sci_Saint @baym you can feed it with money, and hope for the best. that's how a lot of investment works anyway

[Alex Predeus 🇺🇦 @APredeus]

@baym That's an oddly specific number Michael. You seem to know more than you are telling us.