Kevin Sun

Turnkey solution of m2PM for free moving animals imaging | History buff | Road cycling | Deputy General Manager @vivoscope | Opinions my own

[Kevin Sun @A_KwanSun]

Congratulations to the primary authors, Dr. @LunWangm, Dr. @jxqjim, Dr.@Xiaochen_Sun_ , and Dr. @GChattree，along with PI Dr. Mark J. Schnitzer and the team at @Stanford for their groundbreaking work.

[TRANSVISTA @vivoscope]

The parallel revolutions in spatial biology and in vivo microscopy have transformed our ability to record cellular dynamics and profile molecular signatures—yet 𝗹𝗶𝗻𝗸𝗶𝗻𝗴 𝗮𝗰𝘁𝗶𝘃𝗶𝘁𝘆 𝗽𝗮𝘁𝘁𝗲𝗿𝗻𝘀 𝘁𝗼 𝗺𝗼𝗹𝗲𝗰𝘂𝗹𝗮𝗿 𝗶𝗱𝗲𝗻𝘁𝗶𝘁𝘆 𝗶𝗻 𝘁𝗵𝗲 𝗲𝘅𝗮𝗰𝘁 𝘀𝗮𝗺𝗲 𝗰𝗲𝗹𝗹𝘀 has remained a major bottleneck.

We're excited to highlight 𝗧𝗥𝗨-𝗙𝗔𝗖𝗧 (𝗧𝗼𝘁𝗮𝗹 𝗥𝗲𝗴𝗶𝘀𝘁𝗿𝗮𝘁𝗶𝗼𝗻 𝗨𝗻𝗱𝗲𝗿 𝗙𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝗮𝗹 𝗔𝗰𝘁𝗶𝘃𝗶𝘁𝘆, 𝗖𝗼𝗻𝗻𝗲𝗰𝘁𝗶𝘃𝗶𝘁𝘆, 𝗮𝗻𝗱 𝗧𝗿���𝗻𝘀𝗰𝗿𝗶𝗽𝘁𝗼𝗺𝗶𝗰𝘀), a landmark study published as a preprint, "𝘔𝘶𝘭𝘵𝘪𝘮𝘰𝘥𝘢𝘭 𝘢𝘭𝘪𝘨𝘯𝘮𝘦𝘯𝘵𝘴 𝘰𝘧 𝘪𝘯 𝘷𝘪𝘷𝘰 𝘪𝘮𝘢𝘨𝘪𝘯𝘨 𝘢𝘯𝘥 𝘴𝘱𝘢𝘵𝘪𝘢𝘭 𝘣𝘪𝘰𝘭𝘰𝘨𝘺 𝘥𝘢𝘵𝘢𝘴𝘦𝘵𝘴 𝘢𝘵 𝘤𝘦𝘭𝘭𝘶𝘭𝘢𝘳 𝘳𝘦𝘴𝘰𝘭𝘶𝘵𝘪𝘰𝘯" on bioRxiv, which finally bridges this divide. Congratulations to the primary authors, Dr. Lun Wang, Dr. Xiqian Jiang, and Dr. Xiaochen Sun, along with PI Dr. Mark J. Schnitzer and the team at Stanford University.

𝗧𝗵𝗲 𝗧𝗥𝗨-𝗙𝗔𝗖𝗧 𝗪𝗼𝗿𝗸𝗳𝗹𝗼𝘄:

☑️ 𝗔𝗹𝗶𝗴𝗻: An optomechanical strategy physically preserves the orientation of in vivo imaging planes, ensuring postmortem tissue sections are cut precisely parallel—critical for reliable cell matching across modalities.

☑️ 𝗙𝗶𝗻𝗴𝗲𝗿𝗽𝗿𝗶𝗻𝘁: The Soma-print algorithm registers cells by their unique geometric relationship to neighbors, delivering robust matching even with dense populations, thin sections, or distorted tissue.

☑️ 𝗜𝗻𝘁𝗲𝗴𝗿𝗮𝘁𝗲: A statistical framework that provides for each cell an a posteriori probability of correct registration, enabling true multimodal integration—molecular identity, connectivity, and function—for the same individual cells.

Validated across 13 mice which gave 10,522 matched cells, the pipeline works with both low-plex (HCR-FISH) and high-plex (MERFISH, 500-gene) spatial biology methods.

The TRANSVISTA 𝗺𝗶𝗻𝗶𝗮𝘁𝘂𝗿𝗲 𝘁𝘄𝗼-𝗽𝗵𝗼𝘁𝗼𝗻 𝗺𝗶𝗰𝗿𝗼𝘀𝗰𝗼𝗽𝗲 enabled the complete TRU-FACT workflow in 𝗳𝗿𝗲𝗲𝗹𝘆 𝗯𝗲𝗵𝗮𝘃𝗶𝗻𝗴 𝗺𝗶𝗰𝗲, seamlessly connecting naturalistic behavior, cellular activity, and molecular identity in the exact same cells. At TRANSVISTA (https://t.co/f491R4DdHz) , we're proud to support tools that expand what's possible in freely moving brain and behavior research.

Congratulations to the authors for creating a unified framework that opens new possibilities for 𝗹𝗶𝗻𝗸𝗶𝗻𝗴 𝗻𝗮����𝘂𝗿𝗮𝗹𝗶𝘀𝘁𝗶𝗰 𝗯𝗲𝗵𝗮𝘃𝗶𝗼𝗿 𝗮𝗻𝗱 𝗰𝗲𝗹𝗹𝘂𝗹𝗮𝗿 𝗱𝘆𝗻𝗮𝗺𝗶𝗰𝘀 𝘁𝗼 𝗺𝗼𝗹𝗲𝗰𝘂𝗹𝗮𝗿 𝗶𝗱𝗲𝗻𝘁𝗶𝘁𝘆.

Read Article Here: https://t.co/dZQjMYlBpt
Contact the authors: [email protected] (They'll be hosting workshops in the coming months for groups interested in applying this method.)

Contact TRANSVISTA: [email protected]

#Neuroscience #TwoPhotonImaging #SpatialTranscriptomics #CalciumImaging #FreelyMovingMice #BrainResearch #MultimodalIntegration #TRANSVISTA

[Gaurav Chattree @GChattree]

Excited that our TRU-FACT preprint is now live!

TRU-FACT links what individual neurons do in vivo, with who they are molecularly, and who they connect to.

As a neurologist, I’m excited by its potential for understanding and treating circuit disorders.

https://t.co/zFSvbwzq2y

[Xiqian Jiang @jxqjim]

Check our TRU-FACT videos!
Now you can reliably match hundreds to thousands of neurons from in vivo to ex vivo, and perform spatial transcriptomics on the exact same cells throughout its journey!
BioRxiv: https://t.co/XcnebwUHkb

[Xiqian Jiang @jxqjim]

You record beautiful in vivo data…
then spend weeks trying to find the same cells again in tissue.
It’s tedious, fragile, and often unreliable.

We built TRU-FACT to fix this — a scalable way to align cells from in vivo to ex vivo, linking activity with identity.

From tens to hundreds–thousands of cells, with minimal operator dependency.

Now on bioRxiv: https://t.co/fXISEU0LYV

[Fatih Dinc @fatihdin4en]

For decades, two revolutions in neuroscience ran in parallel:

- 🧠 In vivo imaging — watch neurons fire in living animals

- 🧬 Spatial transcriptomics — read cell's molecular identity

Meet TRU-FACT - a graph-based method that matches cells between these datasets at scale 🧵

[Xiaochen Sun @Xiaochen_Sun_]

Excited to share my co-first-authored work on registering in vivo Ca2+ imaging data to ex vivo transcriptomic and projection datasets, enabling the mapping of each cell’s functional coding to its genetic cell type: https://t.co/OfV3HCWOza.

[Kevin Sun @A_KwanSun]

@QingchunTong @uthealthhoupres @UTHealthHouston Congrats Dr. Tong!

[Kevin Sun @A_KwanSun]

Breakthrough in multimodal neuroscience from Mark Schnitzer's team! By bridging in vivo dynamics and molecular profiles, TRU-FACT sets a new bar for cellular resolution. Our TRANSVISTA SN100 was proud to facilitate the free-behavioral recordings in this study. Congrats to Lun!

[Lun Wang @LunWangm]

(1/2)Here is our TRU-FACT preprint:
Multimodal alignments of in vivo imaging and spatial biology datasets at cellular resolution. https://t.co/8GYYoKay5d
Please let us know your comments and send email to [email protected] for workshop trainings.
Let's make science easier!

[TRANSVISTA @vivoscope]

🔬 New at AAD 2026 | Introducing MY600PRO
At the upcoming American Academy of Dermatology Annual Meeting 2026 in Denver, TRANSVISTA will introduce a new addition to our imaging portfolio — MY600PRO.

Designed as a wide-field, co-localized multimodal RCM system, MY600PRO integrates 𝗱𝗲𝗿𝗺𝗼𝘀𝗰𝗼𝗽𝘆 𝗴𝘂𝗶𝗱𝗮𝗻𝗰𝗲 with reflectance confocal microscopy to support 𝗽𝗿𝗲𝗰𝗶𝘀𝗲 𝗹𝗼𝗰𝗮𝗹𝗶𝘇𝗮𝘁𝗶𝗼𝗻 and 𝗵𝗶𝗴𝗵-𝗿𝗲𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻 skin imaging.

✨ 𝗞𝗲𝘆 𝗳𝗲𝗮𝘁𝘂𝗿𝗲𝘀:
• Precise: Dermoscopy-Guided RCM
• Large: 1 mm × 1 mm FOV
• Rapid: 5–10 s Tomography

📌 The system will be presented at the booth through technical materials and discussions.

If you're attending #AAD2026, we welcome you to visit us at 𝗕𝗼𝗼𝘁𝗵 𝟯𝟰𝟲𝟭 to learn more and explore potential applications in skin research and imaging science.

Learn more about us: https://t.co/f491R4CFS1

#AAD2026 #RCM #SkinImaging #BiomedicalImaging #DermatologyResearch #TRANSVISTA

[TRANSVISTA @vivoscope]

🧠 A different kind of 3-minute talk at #BonnBrain2026

As BonnBrain wraps up in Bonn, we wanted to share a snapshot from TRANSVISTA flash talk.

In a 3-minute format, we combined a concise data showcase with a short flash poem —
a different way to frame how we think about imaging neural dynamics in freely behaving animals.

The data speaks for itself.
The poem offers another perspective.

📖 Sharing the full piece here.

Many thanks to the organizers The University of Bonn German Center for Neurodegenerative Diseases (DZNE) Max Planck Institute for Neurobiology of Behavior

Learn more about us: https://t.co/f491R4DdHz

#BonnBrain #Neuroscience #BrainImaging #Mini2P #FHIRM #TRANSVISTA

[TRANSVISTA @vivoscope]

Reflecting on UCL200: Advancing Neuroscience through Collaborative Innovation 🧠

We had a productive time at the UCL200: UCL and Modern Chinese Neuroscience Symposium at UCL. The event provided a fantastic platform to engage with the UK-China neuroscience community on topics ranging from brain-wide networks to the latest in neurotechnology.

At TRANSVISTA (https://t.co/f491R4DdHz), we remain dedicated to supporting neuroscience research through high-resolution, longitudinal neural imaging.

A key focus for us was discussing how our miniaturized two-photon microscope addresses the technical challenge of maintaining 𝘀𝘂𝗯-𝗰𝗲𝗹𝗹𝘂𝗹𝗮𝗿 𝗿𝗲𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻 𝗶𝗻 𝗳𝗿𝗲𝗲𝗹𝘆 𝗺𝗼𝘃𝗶𝗻𝗴 𝗮𝗻𝗶𝗺𝗮𝗹𝘀. This technology enables researchers to capture 𝗵𝗶𝗴𝗵-𝗿𝗲𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻 𝗻𝗲𝘂𝗿𝗮𝗹 𝗮𝗰𝘁𝗶𝘃𝗶𝘁𝘆 𝗼𝘃𝗲𝗿 𝗲𝘅𝘁𝗲𝗻𝗱𝗲𝗱 𝗽𝗲𝗿𝗶𝗼𝗱𝘀, providing deeper insights into how brain circuits drive complex behaviors and how these functional dynamics change over time.

Thank you to the organizers and all the distinguished speakers for an inspiring symposium. We look forward to continuing our support for the global neuroscience community with reliable and precise imaging solutions.

#UCL200 #Neuroscience #TRANSVISTA #Mini2P #InVivo #FreelyMoving

[TRANSVISTA @vivoscope]

𝗧𝗥𝗔𝗡𝗦𝗩𝗜𝗦𝗧𝗔'𝘀 𝗠𝗶𝗻𝗶𝗮𝘁𝘂𝗿𝗶𝘇𝗲𝗱 𝗧𝘄𝗼-𝗣𝗵𝗼𝘁𝗼𝗻 𝗧𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝘆 𝗛𝗲𝗹𝗽𝘀 𝗥𝗲𝘃𝗲𝗮𝗹 𝘁𝗵𝗲 𝗡𝗲𝘄 𝗠𝗲𝗰𝗵𝗮𝗻𝗶𝘀𝗺 𝗼𝗳 𝗔𝘀𝘁𝗿𝗼𝗰𝘆𝘁𝗲-𝗥𝗲𝗴𝘂𝗹𝗮𝘁𝗲𝗱 𝗚𝗹𝘆𝗺𝗽𝗵𝗮𝘁𝗶𝗰 𝗙𝘂𝗻𝗰𝘁𝗶𝗼𝗻 𝗶𝗻 𝗔𝗹𝘇𝗵𝗲𝗶𝗺����𝗿'𝘀 𝗗𝗶𝘀𝗲𝗮𝘀𝗲

Alzheimer's disease is a progressive neurodegenerative disorder that starts decades before cognitive symptoms appear, with amyloid beta and tau tangles accumulating in the brain. As treatments advance, effective biomarkers are needed for different disease stages. Recent studies highlight the glymphatic system's key role in clearing brain pathologies, but more cellular-level research is required.

We would like to acknowledge an interesting research study published in 𝗡𝗮𝘁𝘂𝗿𝗲 𝗡𝗲𝘂𝗿𝗼𝘀𝗰𝗶𝗲𝗻𝗰𝗲, which investigates abnormal calcium dynamics in astrocytes during the early events of Alzheimer's disease and its impact on the glymphatic system. Congratulations to Drs. Yamei Tang, Wei-Jye Lin, Xiaojing Ye and their teams from Sun Yat-sen University for this outstanding work on Alzheimer's disease.

𝗪𝗵𝗮𝘁'𝘀 𝗜𝗻𝗻𝗼𝘃𝗮𝘁𝗶𝘃𝗲:
1️⃣ Abnormal Calcium Dynamics in Astrocytes: The study demonstrates a functional connection between amyloid-β-induced elevation of calcium dynamics in medial prefrontal cortex (mPFC) astrocytes and glymphatic dysfunction in cognitively impaired 5xFAD mice.
2️⃣ Disruption in AQP4 Polarity: Calcium hyperactivity increases cholesterol synthesis in astrocytes, which leads to increased endocytosis of aquaporin-4 (AQP4) and its relocalization to lysosomes.
3️⃣ Rescue of Cognitive Decline: Selective suppression of Gq GPCR-mediated calcium activity in astrocytes (achieved both in vitro and in vivo) significantly improved deficits across multiple cognitive domains previously linked to the mPFC. Notably, anxiety-like behaviors or general locomotor activity were not affected.
4️⃣ Restoration of Glymphatic Reflux: Suppressing Aβ-induced hyperactivity of astrocytic calcium restored glymphatic influx and reversed the disrupted AQP4 polarity.
5️⃣ Cholesterol Biosynthesis: Transcriptional profiling reveals cholesterol biosynthesis as a downstream pathway regulated by astrocytic calcium activity.

𝗠𝘂𝗹𝘁𝗶𝗽𝗵𝗼𝘁𝗼𝗻 𝗜𝗺𝗮𝗴𝗶𝗻𝗴 𝗶𝗻 𝗙𝗿𝗲𝗲𝗹𝘆 𝗕𝗲𝗵𝗮𝘃𝗶𝗻𝗴 𝗠𝗶𝗰𝗲: The study presented exemplary findings in calcium dynamics in the mPFC of 5xFAD mice, utilizing a GRIN lens for enhanced imaging.

At TRANSVISTA (https://t.co/f491R4DdHz), we are committed to supporting cutting-edge neuroscience by providing tools that expand what is possible in brain and behavior research.

Once again, congratulations to the authors and research teams for their work in Alzheimer's disease.

Read Article Here: https://t.co/k3KXUSZhoJ

#Alzheimer's #TwoPhotonImaging #CalciumImaging #FreelyMovingMice #BrainResearch #ScientificData #Neuroscience

[TRANSVISTA @vivoscope]

🧠 Meet TRANSVISTA at BonnBrain 2026

We're excited to join the 8th BonnBrain Conference, held March 23–25 in Bonn.

At 𝗕𝗼𝗼𝘁𝗵 𝟭𝟰, our team will showcase our miniaturized two-photon imaging technology, designed for 𝗹𝗼𝗻𝗴-𝘁𝗲𝗿𝗺, 𝗵𝗶𝗴𝗵-𝗿𝗲𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 𝗼𝗳 𝗻𝗲𝘂𝗿𝗮𝗹 𝗮𝗻𝗱 𝘀𝘆𝗻𝗮𝗽𝘁𝗶𝗰 𝗮𝗰𝘁𝗶𝘃𝗶𝘁𝘆 𝗶𝗻 𝗳𝗿𝗲𝗲𝗹𝘆 𝗯𝗲𝗵𝗮𝘃𝗶𝗻𝗴 𝗮𝗻𝗶𝗺𝗮𝗹𝘀, enabling researchers to directly 𝗹𝗶𝗻𝗸 𝗯𝗿𝗮𝗶𝗻 𝗱𝘆𝗻𝗮𝗺𝗶𝗰𝘀 𝘄𝗶𝘁𝗵 𝗯𝗲𝗵𝗮𝘃𝗶𝗼𝗿.

📍 Booth 14
🔬 Live demo: SUPERNOVA-100 miniature two-photon microscope
🎤 Mini talk
📄 Poster on advances in miniaturized multiphoton microscopy

If you're attending #BonnBrain2026, come and connect with our team — we'd love to connect and exchange ideas with the neuroscience community.

Learn more about us: https://t.co/f491R4CFS1

#BonnBrain #Neuroscience #TwoPhotonMicroscopy #BrainImaging #Mini2P #TRANSVISTA

[TRANSVISTA @vivoscope]

Meet TRANSVISTA at AAD 2026

TRANSVISTA will be exhibiting at the American Academy of Dermatology Annual Meeting 2026 in Denver.

📅 March 27–29, 2026
📍 Booth 3461

At the meeting, we will showcase the 𝗦𝗨𝗣𝗘𝗥𝗩𝗜𝗦𝗜𝗢𝗡-𝟳𝟴𝟬 𝗜𝗻 𝗩𝗶𝘃𝗼 𝗧𝘄𝗼-𝗣𝗵𝗼𝘁𝗼𝗻 𝗜𝗺𝗮𝗴𝗶𝗻𝗴 𝗦𝘆𝘀𝘁𝗲𝗺, designed to support 𝘀𝘂𝗯𝗰𝗲𝗹𝗹𝘂𝗹𝗮𝗿-𝗿𝗲𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻, 𝗹𝗮𝗯𝗲𝗹-𝗳𝗿𝗲𝗲 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 of skin structures 𝗶𝗻 𝗿𝗲𝗮𝗹 𝘁𝗶𝗺𝗲.

The system enables visualization of multiple skin layers — from the stratum corneum to the superficie of dermis — and provides rich structural and endogenous contrast signals for skin biology and dermatology research.

✨ 𝗛𝗶𝗴𝗵𝗹𝗶𝗴𝗵𝘁𝘀 𝗶𝗻𝗰𝗹𝘂𝗱𝗲:
• In vivo, real-time imaging
• Three-dimensional skin visualization
• Label-free endogenous contrast
• Quantitative and functional imaging capabilities

Visit us at 𝗕𝗼𝗼𝘁𝗵 𝟯𝟰𝟲𝟭 to see live demonstrations and learn how 𝗦𝗨𝗣𝗘𝗥𝗩𝗜𝗦𝗜𝗢𝗡 𝟳𝟴𝟬 can expand possibilities in skin science and biomedical research.

Learn more about us: https://t.co/f491R4DdHz

#AAD2026 #SkinImaging #TwophotonMicroscopy #BiomedicalImaging #SkinScience #TRANSVISTA

[Kevin Sun @A_KwanSun]

As we close this year, I am grateful for every partnership, every society that continues to convene, and every scientist who refuses to let uncertainty silence the search for understanding.
Wishing you and yours a healthy happy and prosperous year of 2026🎉🍀🎆

[TRANSVISTA @vivoscope]

❤️‍🔥TRANSVISTA 2025 | Our Word of the Year: 𝐂𝐨𝐧𝐭𝐫𝐢𝐛𝐮𝐭𝐢𝐨𝐧

In 2025, 𝐜𝐨𝐧𝐭𝐫𝐢𝐛𝐮𝐭𝐢𝐨𝐧 guided everything we did:

✔️ 𝟐𝟎+ peer-reviewed publications enabled by TRANSVISTA research and technology.
✔️ 𝟏𝟎+ international scientific meetings supported, including SfN, GRC, and Cold Spring Harbor meetings etc.
✔️ Global on-site support and training delivered by our application scientists and engineers.

Looking ahead to 2026, we 𝐤𝐞𝐞𝐩 𝐦𝐨𝐯𝐢𝐧𝐠 𝐟𝐫𝐞𝐞𝐥𝐲.

#Contribution #Neuroscience #Imaging #mini2P

[Kevin Sun @A_KwanSun]

A remarkable milestone for miniature two-photon imaging. We are proud that our team contributed to this work, helping achieve high-SNR, large-FOV imaging in a truly 1g-class system.

[TRANSVISTA @vivoscope]

🔬 Breakthrough in Brain Imaging: The World's First 1g-Class Compound Metalens Miniature Two-Photon Microscope!

We're thrilled to announce a significant leap forward in miniaturized brain imaging technology: the 𝐌𝐞𝐭𝐚-𝐦𝟐𝐏𝐌 𝟐.𝟎. Weighing only 𝟏.𝟎𝟔 𝐠𝐫𝐚𝐦𝐬, this second-generation compound metalens-based miniature two-photon microscope achieves 𝐡𝐢𝐠𝐡-𝐒𝐍𝐑, 𝐥𝐚𝐫𝐠𝐞-𝐟𝐢𝐞𝐥𝐝-𝐨𝐟-𝐯𝐢𝐞𝐰 𝐢𝐦𝐚𝐠𝐢𝐧𝐠 𝐨𝐟 𝐧𝐞𝐮𝐫𝐨𝐧𝐚𝐥 𝐚𝐜𝐭𝐢𝐯𝐢𝐭𝐲 𝐢𝐧 𝐟𝐫𝐞𝐞𝐥𝐲 𝐛𝐞𝐡𝐚𝐯𝐢𝐧𝐠 𝐦𝐢𝐜𝐞.

This collaborative work, led by teams from Beijing Information Science & Technology University, Harbin Institute of Technology, Peking University, and Beihang University, is now published in #PhotoniX.

𝐖𝐡𝐲 𝐢𝐬 𝐭𝐡𝐢𝐬 𝐚 𝐠𝐚𝐦𝐞-𝐜𝐡𝐚𝐧𝐠𝐞𝐫?
Existing high-performance miniature microscopes often face a critical trade-off: excellent imaging capability comes with a weight penalty (>2g), limiting their use in weight-sensitive animals like songbirds, bats, and pups. While metalenses offered a lightweight promise, single-layer designs struggled with limited field-of-view and off-axis aberrations.

Our Solution: A "Two-Stage Imaging" Compound Metalens Architecture
By decoupling the scanning and focusing functions using a novel dual-layer metalens design, we broke the traditional balance between weight, FOV, and resolution.

𝐊𝐞𝐲 𝐀𝐜𝐡𝐢𝐞𝐯𝐞𝐦𝐞𝐧𝐭𝐬 𝐨𝐟 𝐌𝐞𝐭𝐚-𝐦𝟐𝐏𝐌 𝟐.𝟎:
▪️ Ultralight Weight: Probe head at 1.06g (lens weight reduced to 1/10 of conventional designs).
▪️ Large FOV: 350×330 µm², a >50x improvement over the first generation.
▪️ High Resolution: 1.17 µm laterally, maintaining >80% resolution even at the FOV edge.
▪️ High Stability: 90% field displacement <5 µm during short-term tests, enabling reliable long-term tracking of the same neurons across days in freely moving mice.

This work successfully transitions metalens technology from a lab concept to a practical tool capable of supporting high-quality, natural-behavior brain function imaging.

Looking ahead, this technology paves the way for free-behavior multicolor imaging, multi-region synchronous observation, and cross-species neural circuit studies, with potential impacts on understanding brain cognition, early disease diagnosis, and neuropharmaceutical evaluation.

Huge congratulations to the entire team, especially first authors Zeyu Hao and Yao Zhang, and corresponding authors Prof. Runlong Wu, Prof. Shumin Xiao, and Prof. Aimin Wang.

Read the full paper in PhotoniX: https://t.co/Bw2ofW2eIP
Learn More about TRANSVISTA: https://t.co/f491R4DdHz

#Neuroscience #BrainImaging #TwoPhotonMicroscopy #m2PM #mini2P

[TRANSVISTA @vivoscope]

🎉 Happy holidays!

As 2025 comes to a close, we extend our deepest gratitude for your partnership and shared journey. Wishing you and your family a wonderful New Year filled with health, success, and happiness.

We look forward to continuing our journey of discovery with you in 2026 —— Empowering discovery through advanced in vivo imaging, illuminating the brain and beyond.

#Neuroscience #mini2p #imaging #transvista

[TRANSVISTA @vivoscope]

🎉 SfN 2025 has officially wrapped up!

Thank you to everyone who visited TRANSVISTA Booth #913, joined our discussions, and shared their research needs with us over the past four days.

We appreciate the strong interest in SUPERNOVA-100 and LEAPSONICS, and the many valuable conversations around miniature multiphoton imaging for freely moving animals and its future applications.

To close the meeting — let's keep moving freely!

Looking forward to continuing the conversations after SfN.

Contact us: [email protected]
Learn more about us: https://t.co/f491R4DdHz

#SfN2025 #Neuroscience #Mini2P #InVivoImaging #BrainImaging #FreelyMovingAnimals

[Richard Kozma @kozmarichard92]

Come to the booth number 913.
We offer kindness, professionalism + some cute pandas ( toys )

[TRANSVISTA @vivoscope]

💡 It has been an incredibly vibrant and productive first three days at #SfN2025!

We're grateful for the tremendous engagement, insightful conversations, and continued enthusiasm at the TRANSVISTA booth.

A special thank-you to everyone who joined our Meet the Expert sessions with:

🔹 𝐋𝐨𝐧𝐠𝐣𝐮𝐧 𝐖𝐮, 𝐏𝐡𝐃
Professor and Founding Director, IMM–Center for Neuroimmunology and Glial Biology, UTHealth Houston

🔹 𝐘𝐮𝐡𝐚𝐧 𝐙𝐡𝐚𝐧𝐠
PhD Student, Ge-Xiong Lab, Department of Neurobiology and Behavior, Stony Brook University

They shared their in-depth experiences using 𝐒𝐔𝐏𝐄𝐑𝐍𝐎𝐕𝐀-𝟏𝟎𝟎 and 𝐒𝐔𝐏𝐄𝐑𝐍𝐎𝐕𝐀-𝟔𝟎𝟎 miniature two-photon microscopes, sparking valuable conversations with many interested visitors.

🧠 𝐏𝐨𝐬𝐭𝐞𝐫 𝐇𝐢𝐠𝐡𝐥𝐢𝐠𝐡𝐭
Yuhan Zhang presented:
“𝐒𝐭𝐮𝐝𝐲𝐢𝐧𝐠 𝐫𝐞𝐰𝐚𝐫𝐝 𝐞𝐧����𝐨𝐝𝐢𝐧𝐠 𝐢𝐧 𝐭𝐡𝐞 𝐚𝐮𝐝𝐢𝐭𝐨𝐫𝐲 𝐜𝐞𝐧𝐭𝐫𝐚𝐥 𝐩𝐫𝐨𝐜𝐞𝐬𝐬𝐢𝐧𝐠 𝐩𝐚𝐭𝐡𝐰𝐚𝐲 𝐮𝐬𝐢𝐧𝐠 𝐭𝐰𝐨-𝐩𝐡𝐨𝐭𝐨𝐧 𝐢𝐦𝐚𝐠𝐢𝐧𝐠 𝐢𝐧 𝐟𝐫𝐞𝐞𝐥𝐲 𝐛𝐞𝐡𝐚𝐯𝐢𝐧𝐠 𝐦𝐢𝐜𝐞."
She showcased how SUPERNOVA-600's 𝐝𝐮𝐚𝐥-𝐜𝐡𝐚𝐧��𝐞𝐥 𝐚𝐩𝐩𝐫𝐨𝐚𝐜𝐡 is helping uncover the neural mechanisms linking sensory inputs and reward processing.

🔬 𝐍𝐚𝐧𝐨𝐬𝐲𝐦𝐩𝐨𝐬𝐢𝐮𝐦 𝐇𝐢𝐠𝐡𝐥𝐢𝐠𝐡𝐭
Dr. Runlong Wu presented exciting results on:
“𝐀 𝐥𝐨𝐧𝐠-𝐰𝐨𝐫𝐤𝐢𝐧𝐠 𝐝𝐢𝐬𝐭𝐚𝐧𝐜𝐞 𝐦𝐢𝐧𝐢𝐚𝐭𝐮𝐫𝐞 𝐭𝐰𝐨-𝐩𝐡𝐨𝐭𝐨𝐧 𝐦𝐢𝐜𝐫𝐨𝐬𝐜𝐨𝐩𝐞 𝐞𝐧𝐚𝐛𝐥𝐞𝐬 𝐜𝐫𝐨𝐬𝐬-𝐬𝐩𝐞𝐜𝐢𝐞𝐬 𝐢𝐦𝐚𝐠𝐢𝐧𝐠 𝐟𝐫𝐨𝐦 𝐫𝐨𝐝𝐞𝐧𝐭𝐬 𝐭𝐨 𝐧𝐨𝐧𝐡𝐮𝐦𝐚𝐧 𝐩𝐫𝐢𝐦𝐚𝐭𝐞𝐬.”
A powerful demonstration of how miniature multiphoton imaging is expanding into 𝐧𝐨𝐧𝐡𝐮𝐦𝐚𝐧 𝐩𝐫𝐢𝐦𝐚𝐭𝐞𝐬.

📍 Tomorrow is the final day of SfN 2025!

If you haven't visited yet — or if you want to dive deeper into our technologies — come see us at Booth #913.

Let's make the last day count!

#SfN2025 #Neuroscience #TwoPhotonImaging #Mini2P #InVivoImaging #FreelyMovingAnimals #BrainImaging