Congratulations to the primary authors, Dr. @LunWangm, Dr. @jxqjim, Dr.@Xiaochen_Sun_ , and Dr. @GChattree๏ผalong with PI Dr. Mark J. Schnitzer and the team at @Stanford for their groundbreaking work.
The parallel revolutions in spatial biology and in vivo microscopy have transformed our ability to record cellular dynamics and profile molecular signaturesโyet ๐น๐ถ๐ป๐ธ๐ถ๐ป๐ด ๐ฎ๐ฐ๐๐ถ๐๐ถ๐๐ ๐ฝ๐ฎ๐๐๐ฒ๐ฟ๐ป๐ ๐๐ผ ๐บ๐ผ๐น๐ฒ๐ฐ๐๐น๐ฎ๐ฟ ๐ถ๐ฑ๐ฒ๐ป๐๐ถ๐๐ ๐ถ๐ป ๐๐ต๐ฒ ๐ฒ๐ ๐ฎ๐ฐ๐ ๐๐ฎ๐บ๐ฒ ๐ฐ๐ฒ๐น๐น๐ has remained a major bottleneck.
We're excited to highlight ๐ง๐ฅ๐จ-๐๐๐๐ง (๐ง๐ผ๐๐ฎ๐น ๐ฅ๐ฒ๐ด๐ถ๐๐๐ฟ๐ฎ๐๐ถ๐ผ๐ป ๐จ๐ป๐ฑ๐ฒ๐ฟ ๐๐๐ป๐ฐ๐๐ถ๐ผ๐ป๐ฎ๐น ๐๐ฐ๐๐ถ๐๐ถ๐๐, ๐๐ผ๐ป๐ป๐ฒ๐ฐ๐๐ถ๐๐ถ๐๐, ๐ฎ๐ป๐ฑ ๐ง๐ฟ๏ฟฝ๏ฟฝ๏ฟฝ๐ป๐๐ฐ๐ฟ๐ถ๐ฝ๐๐ผ๐บ๐ถ๐ฐ๐), a landmark study published as a preprint, "๐๐ถ๐ญ๐ต๐ช๐ฎ๐ฐ๐ฅ๐ข๐ญ ๐ข๐ญ๐ช๐จ๐ฏ๐ฎ๐ฆ๐ฏ๐ต๐ด ๐ฐ๐ง ๐ช๐ฏ ๐ท๐ช๐ท๐ฐ ๐ช๐ฎ๐ข๐จ๐ช๐ฏ๐จ ๐ข๐ฏ๐ฅ ๐ด๐ฑ๐ข๐ต๐ช๐ข๐ญ ๐ฃ๐ช๐ฐ๐ญ๐ฐ๐จ๐บ ๐ฅ๐ข๐ต๐ข๐ด๐ฆ๐ต๐ด ๐ข๐ต ๐ค๐ฆ๐ญ๐ญ๐ถ๐ญ๐ข๐ณ ๐ณ๐ฆ๐ด๐ฐ๐ญ๐ถ๐ต๐ช๐ฐ๐ฏ" on bioRxiv, which finally bridges this divide. Congratulations to the primary authors, Dr. Lun Wang, Dr. Xiqian Jiang, and Dr. Xiaochen Sun, along with PI Dr. Mark J. Schnitzer and the team at Stanford University.
๐ง๐ต๐ฒ ๐ง๐ฅ๐จ-๐๐๐๐ง ๐ช๐ผ๐ฟ๐ธ๐ณ๐น๐ผ๐:
โ๏ธ ๐๐น๐ถ๐ด๐ป: An optomechanical strategy physically preserves the orientation of in vivo imaging planes, ensuring postmortem tissue sections are cut precisely parallelโcritical for reliable cell matching across modalities.
โ๏ธ ๐๐ถ๐ป๐ด๐ฒ๐ฟ๐ฝ๐ฟ๐ถ๐ป๐: The Soma-print algorithm registers cells by their unique geometric relationship to neighbors, delivering robust matching even with dense populations, thin sections, or distorted tissue.
โ๏ธ ๐๐ป๐๐ฒ๐ด๐ฟ๐ฎ๐๐ฒ: A statistical framework that provides for each cell an a posteriori probability of correct registration, enabling true multimodal integrationโmolecular identity, connectivity, and functionโfor the same individual cells.
Validated across 13 mice which gave 10,522 matched cells, the pipeline works with both low-plex (HCR-FISH) and high-plex (MERFISH, 500-gene) spatial biology methods.
The TRANSVISTA ๐บ๐ถ๐ป๐ถ๐ฎ๐๐๐ฟ๐ฒ ๐๐๐ผ-๐ฝ๐ต๐ผ๐๐ผ๐ป ๐บ๐ถ๐ฐ๐ฟ๐ผ๐๐ฐ๐ผ๐ฝ๐ฒ enabled the complete TRU-FACT workflow in ๐ณ๐ฟ๐ฒ๐ฒ๐น๐ ๐ฏ๐ฒ๐ต๐ฎ๐๐ถ๐ป๐ด ๐บ๐ถ๐ฐ๐ฒ, seamlessly connecting naturalistic behavior, cellular activity, and molecular identity in the exact same cells. At TRANSVISTA (https://t.co/f491R4DdHz) , we're proud to support tools that expand what's possible in freely moving brain and behavior research.
Congratulations to the authors for creating a unified framework that opens new possibilities for ๐น๐ถ๐ป๐ธ๐ถ๐ป๐ด ๐ป๐ฎ๏ฟฝ๏ฟฝ๏ฟฝ๏ฟฝ๐๐ฟ๐ฎ๐น๐ถ๐๐๐ถ๐ฐ ๐ฏ๐ฒ๐ต๐ฎ๐๐ถ๐ผ๐ฟ ๐ฎ๐ป๐ฑ ๐ฐ๐ฒ๐น๐น๐๐น๐ฎ๐ฟ ๐ฑ๐๐ป๐ฎ๐บ๐ถ๐ฐ๐ ๐๐ผ ๐บ๐ผ๐น๐ฒ๐ฐ๐๐น๐ฎ๐ฟ ๐ถ๐ฑ๐ฒ๐ป๐๐ถ๐๐.
Read Article Here: https://t.co/dZQjMYlBpt
Contact the authors: [email protected] (They'll be hosting workshops in the coming months for groups interested in applying this method.)
Contact TRANSVISTA: [email protected]
#Neuroscience #TwoPhotonImaging #SpatialTranscriptomics #CalciumImaging #FreelyMovingMice #BrainResearch #MultimodalIntegration #TRANSVISTA
Excited that our TRU-FACT preprint is now live!
TRU-FACT links what individual neurons do in vivo, with who they are molecularly, and who they connect to.
As a neurologist, Iโm excited by its potential for understanding and treating circuit disorders.
https://t.co/zFSvbwzq2y
Check our TRU-FACT videos!
Now you can reliably match hundreds to thousands of neurons from in vivo to ex vivo, and perform spatial transcriptomics on the exact same cells throughout its journey!
BioRxiv: https://t.co/XcnebwUHkb
You record beautiful in vivo dataโฆ
then spend weeks trying to find the same cells again in tissue.
Itโs tedious, fragile, and often unreliable.
We built TRU-FACT to fix this โ a scalable way to align cells from in vivo to ex vivo, linking activity with identity.
From tens to hundredsโthousands of cells, with minimal operator dependency.
Now on bioRxiv: https://t.co/fXISEU0LYV
For decades, two revolutions in neuroscience ran in parallel:
- ๐ง In vivo imaging โ watch neurons fire in living animals
- ๐งฌ Spatial transcriptomics โ read cell's molecular identity
Meet TRU-FACT - a graph-based method that matches cells between these datasets at scale ๐งต
Excited to share my co-first-authored work on registering in vivo Ca2+ imaging data to ex vivo transcriptomic and projection datasets, enabling the mapping of each cellโs functional coding to its genetic cell type: https://t.co/OfV3HCWOza.
Breakthrough in multimodal neuroscience from Mark Schnitzer's team! By bridging in vivo dynamics and molecular profiles, TRU-FACT sets a new bar for cellular resolution. Our TRANSVISTA SN100 was proud to facilitate the free-behavioral recordings in this study. Congrats to Lun!
(1/2)Here is our TRU-FACT preprint:
Multimodal alignments of in vivo imaging and spatial biology datasets at cellular resolution. https://t.co/8GYYoKay5d
Please let us know your comments and send email to [email protected] for workshop trainings.
Let's make science easier!
๐ฌ New at AAD 2026 | Introducing MY600PRO
At the upcoming American Academy of Dermatology Annual Meeting 2026 in Denver, TRANSVISTA will introduce a new addition to our imaging portfolio โ MY600PRO.
Designed as a wide-field, co-localized multimodal RCM system, MY600PRO integrates ๐ฑ๐ฒ๐ฟ๐บ๐ผ๐๐ฐ๐ผ๐ฝ๐ ๐ด๐๐ถ๐ฑ๐ฎ๐ป๐ฐ๐ฒ with reflectance confocal microscopy to support ๐ฝ๐ฟ๐ฒ๐ฐ๐ถ๐๐ฒ ๐น๐ผ๐ฐ๐ฎ๐น๐ถ๐๐ฎ๐๐ถ๐ผ๐ป and ๐ต๐ถ๐ด๐ต-๐ฟ๐ฒ๐๐ผ๐น๐๐๐ถ๐ผ๐ป skin imaging.
โจ ๐๐ฒ๐ ๐ณ๐ฒ๐ฎ๐๐๐ฟ๐ฒ๐:
โข Precise: Dermoscopy-Guided RCM
โข Large: 1 mm ร 1 mm FOV
โข Rapid: 5โ10 s Tomography
๐ The system will be presented at the booth through technical materials and discussions.
If you're attending #AAD2026, we welcome you to visit us at ๐๐ผ๐ผ๐๐ต ๐ฏ๐ฐ๐ฒ๐ญ to learn more and explore potential applications in skin research and imaging science.
Learn more about us: https://t.co/f491R4CFS1
#AAD2026 #RCM #SkinImaging #BiomedicalImaging #DermatologyResearch #TRANSVISTA
๐ง A different kind of 3-minute talk at #BonnBrain2026
As BonnBrain wraps up in Bonn, we wanted to share a snapshot from TRANSVISTA flash talk.
In a 3-minute format, we combined a concise data showcase with a short flash poem โ
a different way to frame how we think about imaging neural dynamics in freely behaving animals.
The data speaks for itself.
The poem offers another perspective.
๐ Sharing the full piece here.
Many thanks to the organizers The University of Bonn German Center for Neurodegenerative Diseases (DZNE) Max Planck Institute for Neurobiology of Behavior
Learn more about us: https://t.co/f491R4DdHz
#BonnBrain #Neuroscience #BrainImaging #Mini2P #FHIRM #TRANSVISTA
Reflecting on UCL200: Advancing Neuroscience through Collaborative Innovation ๐ง
We had a productive time at theย UCL200: UCL and Modern Chinese Neuroscience Symposiumย at UCL. The event provided a fantastic platform to engage with the UK-China neuroscience community on topics ranging from brain-wide networks to the latest in neurotechnology.
At TRANSVISTA (https://t.co/f491R4DdHz), we remain dedicated to supporting neuroscience research throughย high-resolution, longitudinal neural imaging.
A key focus for us was discussing how our miniaturized two-photon microscope addresses the technical challenge ofย maintaining ๐๐๐ฏ-๐ฐ๐ฒ๐น๐น๐๐น๐ฎ๐ฟ ๐ฟ๐ฒ๐๐ผ๐น๐๐๐ถ๐ผ๐ป ๐ถ๐ป ๐ณ๐ฟ๐ฒ๐ฒ๐น๐ ๐บ๐ผ๐๐ถ๐ป๐ด ๐ฎ๐ป๐ถ๐บ๐ฎ๐น๐. This technology enables researchers toย capture ๐ต๐ถ๐ด๐ต-๐ฟ๐ฒ๐๐ผ๐น๐๐๐ถ๐ผ๐ป ๐ป๐ฒ๐๐ฟ๐ฎ๐น ๐ฎ๐ฐ๐๐ถ๐๐ถ๐๐ ๐ผ๐๐ฒ๐ฟ ๐ฒ๐ ๐๐ฒ๐ป๐ฑ๐ฒ๐ฑ ๐ฝ๐ฒ๐ฟ๐ถ๐ผ๐ฑ๐, providing deeper insights intoย how brain circuits drive complex behaviorsย and how these functional dynamics change over time.
Thank you to the organizersย and all the distinguished speakers for an inspiring symposium. We look forward to continuing our support for the global neuroscience community with reliable and precise imaging solutions.
#UCL200 #Neuroscience #TRANSVISTA #Mini2P #InVivo #FreelyMoving
๐ง๐ฅ๐๐ก๐ฆ๐ฉ๐๐ฆ๐ง๐'๐ ๐ ๐ถ๐ป๐ถ๐ฎ๐๐๐ฟ๐ถ๐๐ฒ๐ฑ ๐ง๐๐ผ-๐ฃ๐ต๐ผ๐๐ผ๐ป ๐ง๐ฒ๐ฐ๐ต๐ป๐ผ๐น๐ผ๐ด๐ ๐๐ฒ๐น๐ฝ๐ ๐ฅ๐ฒ๐๐ฒ๐ฎ๐น ๐๐ต๐ฒ ๐ก๐ฒ๐ ๐ ๐ฒ๐ฐ๐ต๐ฎ๐ป๐ถ๐๐บ ๐ผ๐ณ ๐๐๐๐ฟ๐ผ๐ฐ๐๐๐ฒ-๐ฅ๐ฒ๐ด๐๐น๐ฎ๐๐ฒ๐ฑ ๐๐น๐๐บ๐ฝ๐ต๐ฎ๐๐ถ๐ฐ ๐๐๐ป๐ฐ๐๐ถ๐ผ๐ป ๐ถ๐ป ๐๐น๐๐ต๐ฒ๐ถ๐บ๏ฟฝ๏ฟฝ๏ฟฝ๏ฟฝ๐ฟ'๐ ๐๐ถ๐๐ฒ๐ฎ๐๐ฒ
Alzheimer's disease is a progressive neurodegenerative disorder that starts decades before cognitive symptoms appear, with amyloid beta and tau tangles accumulating in the brain. As treatments advance, effective biomarkers are needed for different disease stages. Recent studies highlight the glymphatic system's key role in clearing brain pathologies, but more cellular-level research is required.
We would like to acknowledge an interesting research study published in ๐ก๐ฎ๐๐๐ฟ๐ฒ ๐ก๐ฒ๐๐ฟ๐ผ๐๐ฐ๐ถ๐ฒ๐ป๐ฐ๐ฒ, which investigates abnormal calcium dynamics in astrocytes during the early events of Alzheimer's disease and its impact on the glymphatic system. Congratulations to Drs. Yamei Tang, Wei-Jye Lin, Xiaojing Ye and their teams from Sun Yat-sen University for this outstanding work on Alzheimer's disease.
๐ช๐ต๐ฎ๐'๐ ๐๐ป๐ป๐ผ๐๐ฎ๐๐ถ๐๐ฒ:
1๏ธโฃ Abnormal Calcium Dynamics in Astrocytes: The study demonstrates a functional connection between amyloid-ฮฒ-induced elevation of calcium dynamics in medial prefrontal cortex (mPFC) astrocytes and glymphatic dysfunction in cognitively impaired 5xFAD mice.
2๏ธโฃ Disruption in AQP4 Polarity: Calcium hyperactivity increases cholesterol synthesis in astrocytes, which leads to increased endocytosis of aquaporin-4 (AQP4) and its relocalization to lysosomes.
3๏ธโฃ Rescue of Cognitive Decline: Selective suppression of Gq GPCR-mediated calcium activity in astrocytes (achieved both in vitro and in vivo) significantly improved deficits across multiple cognitive domains previously linked to the mPFC. Notably, anxiety-like behaviors or general locomotor activity were not affected.
4๏ธโฃ Restoration of Glymphatic Reflux: Suppressing Aฮฒ-induced hyperactivity of astrocytic calcium restored glymphatic influx and reversed the disrupted AQP4 polarity.
5๏ธโฃ Cholesterol Biosynthesis: Transcriptional profiling reveals cholesterol biosynthesis as a downstream pathway regulated by astrocytic calcium activity.
๐ ๐๐น๐๐ถ๐ฝ๐ต๐ผ๐๐ผ๐ป ๐๐บ๐ฎ๐ด๐ถ๐ป๐ด ๐ถ๐ป ๐๐ฟ๐ฒ๐ฒ๐น๐ ๐๐ฒ๐ต๐ฎ๐๐ถ๐ป๐ด ๐ ๐ถ๐ฐ๐ฒ: The study presented exemplary findings in calcium dynamics in the mPFC of 5xFAD mice, utilizing a GRIN lens for enhanced imaging.
At TRANSVISTA (https://t.co/f491R4DdHz), we are committed to supporting cutting-edge neuroscience by providing tools that expand what is possible in brain and behavior research.
Once again, congratulations to the authors and research teams for their work in Alzheimer's disease.
Read Article Here: https://t.co/k3KXUSZhoJ
#Alzheimer's #TwoPhotonImaging #CalciumImaging #FreelyMovingMice #BrainResearch #ScientificData #Neuroscience
๐ง Meet TRANSVISTA at BonnBrain 2026
We're excited to join the 8th BonnBrain Conference, held March 23โ25 in Bonn.
At ๐๐ผ๐ผ๐๐ต ๐ญ๐ฐ, our team will showcase our miniaturized two-photon imaging technology, designed for ๐น๐ผ๐ป๐ด-๐๐ฒ๐ฟ๐บ, ๐ต๐ถ๐ด๐ต-๐ฟ๐ฒ๐๐ผ๐น๐๐๐ถ๐ผ๐ป ๐ถ๐บ๐ฎ๐ด๐ถ๐ป๐ด ๐ผ๐ณ ๐ป๐ฒ๐๐ฟ๐ฎ๐น ๐ฎ๐ป๐ฑ ๐๐๐ป๐ฎ๐ฝ๐๐ถ๐ฐ ๐ฎ๐ฐ๐๐ถ๐๐ถ๐๐ ๐ถ๐ป ๐ณ๐ฟ๐ฒ๐ฒ๐น๐ ๐ฏ๐ฒ๐ต๐ฎ๐๐ถ๐ป๐ด ๐ฎ๐ป๐ถ๐บ๐ฎ๐น๐, enabling researchers to directly ๐น๐ถ๐ป๐ธ ๐ฏ๐ฟ๐ฎ๐ถ๐ป ๐ฑ๐๐ป๐ฎ๐บ๐ถ๐ฐ๐ ๐๐ถ๐๐ต ๐ฏ๐ฒ๐ต๐ฎ๐๐ถ๐ผ๐ฟ.
๐ Booth 14
๐ฌ Live demo: SUPERNOVA-100 miniature two-photon microscope
๐ค Mini talk
๐ Poster on advances in miniaturized multiphoton microscopy
If you're attending #BonnBrain2026, come and connect with our team โ we'd love to connect and exchange ideas with the neuroscience community.
Learn more about us: https://t.co/f491R4CFS1
#BonnBrain #Neuroscience #TwoPhotonMicroscopy #BrainImaging #Mini2P #TRANSVISTA
Meet TRANSVISTA at AAD 2026
TRANSVISTA will be exhibiting at the American Academy of Dermatology Annual Meeting 2026 in Denver.
๐ March 27โ29, 2026
๐ Booth 3461
At the meeting, we will showcase the ๐ฆ๐จ๐ฃ๐๐ฅ๐ฉ๐๐ฆ๐๐ข๐ก-๐ณ๐ด๐ฌ ๐๐ป ๐ฉ๐ถ๐๐ผ ๐ง๐๐ผ-๐ฃ๐ต๐ผ๐๐ผ๐ป ๐๐บ๐ฎ๐ด๐ถ๐ป๐ด ๐ฆ๐๐๐๐ฒ๐บ, designed to support ๐๐๐ฏ๐ฐ๐ฒ๐น๐น๐๐น๐ฎ๐ฟ-๐ฟ๐ฒ๐๐ผ๐น๐๐๐ถ๐ผ๐ป, ๐น๐ฎ๐ฏ๐ฒ๐น-๐ณ๐ฟ๐ฒ๐ฒ ๐ถ๐บ๐ฎ๐ด๐ถ๐ป๐ด of skin structures ๐ถ๐ป ๐ฟ๐ฒ๐ฎ๐น ๐๐ถ๐บ๐ฒ.
The system enables visualization of multiple skin layers โ from the stratum corneum to the superficie of dermis โ and provides rich structural and endogenous contrast signals for skin biology and dermatology research.
โจ ๐๐ถ๐ด๐ต๐น๐ถ๐ด๐ต๐๐ ๐ถ๐ป๐ฐ๐น๐๐ฑ๐ฒ:
โข In vivo, real-time imaging
โข Three-dimensional skin visualization
โข Label-free endogenous contrast
โข Quantitative and functional imaging capabilities
Visit us at ๐๐ผ๐ผ๐๐ต ๐ฏ๐ฐ๐ฒ๐ญ to see live demonstrations and learn how ๐ฆ๐จ๐ฃ๐๐ฅ๐ฉ๐๐ฆ๐๐ข๐ก ๐ณ๐ด๐ฌ can expand possibilities in skin science and biomedical research.
Learn more about us: https://t.co/f491R4DdHz
#AAD2026 #SkinImaging #TwophotonMicroscopy #BiomedicalImaging #SkinScience #TRANSVISTA
As we close this year, I am grateful for every partnership, every society that continues to convene, and every scientist who refuses to let uncertainty silence the search for understanding.
Wishing you and yours a healthy happy and prosperous year of 2026๐๐๐
โค๏ธโ๐ฅTRANSVISTA 2025 | Our Word of the Year: ๐๐จ๐ง๐ญ๐ซ๐ข๐๐ฎ๐ญ๐ข๐จ๐ง
In 2025, ๐๐จ๐ง๐ญ๐ซ๐ข๐๐ฎ๐ญ๐ข๐จ๐ง guided everything we did:
โ๏ธ ๐๐+ peer-reviewed publications enabled by TRANSVISTA research and technology.
โ๏ธ ๐๐+ international scientific meetings supported, including SfN, GRC, and Cold Spring Harbor meetings etc.
โ๏ธ Global on-site support and training delivered by our application scientists and engineers.
Looking ahead to 2026, we ๐ค๐๐๐ฉ ๐ฆ๐จ๐ฏ๐ข๐ง๐ ๐๐ซ๐๐๐ฅ๐ฒ.
#Contribution #Neuroscience #Imaging #mini2P
A remarkable milestone for miniature two-photon imaging. We are proud that our team contributed to this work, helping achieve high-SNR, large-FOV imaging in a truly 1g-class system.
๐ฌ Breakthrough in Brain Imaging: The World's First 1g-Class Compound Metalens Miniature Two-Photon Microscope!
We're thrilled to announce a significant leap forward in miniaturized brain imaging technology: the ๐๐๐ญ๐-๐ฆ๐๐๐ ๐.๐. Weighing only ๐.๐๐ ๐ ๐ซ๐๐ฆ๐ฌ, this second-generation compound metalens-based miniature two-photon microscope achieves ๐ก๐ข๐ ๐ก-๐๐๐, ๐ฅ๐๐ซ๐ ๐-๐๐ข๐๐ฅ๐-๐จ๐-๐ฏ๐ข๐๐ฐ ๐ข๐ฆ๐๐ ๐ข๐ง๐ ๐จ๐ ๐ง๐๐ฎ๐ซ๐จ๐ง๐๐ฅ ๐๐๐ญ๐ข๐ฏ๐ข๐ญ๐ฒ ๐ข๐ง ๐๐ซ๐๐๐ฅ๐ฒ ๐๐๐ก๐๐ฏ๐ข๐ง๐ ๐ฆ๐ข๐๐.
This collaborative work, led by teams from Beijing Information Science & Technology University, Harbin Institute of Technology, Peking University, and Beihang University, is now published in #PhotoniX.
๐๐ก๐ฒ ๐ข๐ฌ ๐ญ๐ก๐ข๐ฌ ๐ ๐ ๐๐ฆ๐-๐๐ก๐๐ง๐ ๐๐ซ?
Existing high-performance miniature microscopes often face a critical trade-off: excellent imaging capability comes with a weight penalty (>2g), limiting their use in weight-sensitive animals like songbirds, bats, and pups. While metalenses offered a lightweight promise, single-layer designs struggled with limited field-of-view and off-axis aberrations.
Our Solution: A "Two-Stage Imaging" Compound Metalens Architecture
By decoupling the scanning and focusing functions using a novel dual-layer metalens design, we broke the traditional balance between weight, FOV, and resolution.
๐๐๐ฒ ๐๐๐ก๐ข๐๐ฏ๐๐ฆ๐๐ง๐ญ๐ฌ ๐จ๐ ๐๐๐ญ๐-๐ฆ๐๐๐ ๐.๐:
โช๏ธ Ultralight Weight: Probe head at 1.06g (lens weight reduced to 1/10 of conventional designs).
โช๏ธ Large FOV: 350ร330 ยตmยฒ, a >50x improvement over the first generation.
โช๏ธ High Resolution: 1.17 ยตm laterally, maintaining >80% resolution even at the FOV edge.
โช๏ธ High Stability: 90% field displacement <5 ยตm during short-term tests, enabling reliable long-term tracking of the same neurons across days in freely moving mice.
This work successfully transitions metalens technology from a lab concept to a practical tool capable of supporting high-quality, natural-behavior brain function imaging.
Looking ahead, this technology paves the way for free-behavior multicolor imaging, multi-region synchronous observation, and cross-species neural circuit studies, with potential impacts on understanding brain cognition, early disease diagnosis, and neuropharmaceutical evaluation.
Huge congratulations to the entire team, especially first authors Zeyu Hao and Yao Zhang, and corresponding authors Prof. Runlong Wu, Prof. Shumin Xiao, and Prof. Aimin Wang.
Read the full paper in PhotoniX: https://t.co/Bw2ofW2eIP
Learn More about TRANSVISTA: https://t.co/f491R4DdHz
#Neuroscience #BrainImaging #TwoPhotonMicroscopy #m2PM #mini2P
๐ Happy holidays!
As 2025 comes to a close, we extend our deepest gratitude for your partnership and shared journey. Wishing you and your family a wonderful New Year filled with health, success, and happiness.
We look forward to continuing our journey of discovery with you in 2026 โโ Empowering discovery through advanced in vivo imaging, illuminating the brain and beyond.
#Neuroscience #mini2p #imaging #transvista
๐ SfN 2025 has officially wrapped up!
Thank you to everyone who visited TRANSVISTA Booth #913, joined our discussions, and shared their research needs with us over the past four days.
We appreciate the strong interest in SUPERNOVA-100 and LEAPSONICS, and the many valuable conversations around miniature multiphoton imaging for freely moving animals and its future applications.
To close the meeting โ let's keep moving freely!
Looking forward to continuing the conversations after SfN.
Contact us: [email protected]
Learn more about us: https://t.co/f491R4DdHz
#SfN2025 #Neuroscience #Mini2P #InVivoImaging #BrainImaging #FreelyMovingAnimals
๐ก It has been an incredibly vibrant and productive first three days at #SfN2025!
We're grateful for the tremendous engagement, insightful conversations, and continued enthusiasm at the TRANSVISTA booth.
A special thank-you to everyone who joined our Meet the Expert sessions with:
๐น ๐๐จ๐ง๐ ๐ฃ๐ฎ๐ง ๐๐ฎ, ๐๐ก๐
Professor and Founding Director, IMMโCenter for Neuroimmunology and Glial Biology, UTHealth Houston
๐น ๐๐ฎ๐ก๐๐ง ๐๐ก๐๐ง๐
PhD Student, Ge-Xiong Lab, Department of Neurobiology and Behavior, Stony Brook University
They shared their in-depth experiences using ๐๐๐๐๐๐๐๐๐-๐๐๐ and ๐๐๐๐๐๐๐๐๐-๐๐๐ miniature two-photon microscopes, sparking valuable conversations with many interested visitors.
๐ง ๐๐จ๐ฌ๐ญ๐๐ซ ๐๐ข๐ ๐ก๐ฅ๐ข๐ ๐ก๐ญ
Yuhan Zhang presented:
โ๐๐ญ๐ฎ๐๐ฒ๐ข๐ง๐ ๐ซ๐๐ฐ๐๐ซ๐ ๐๐ง๏ฟฝ๏ฟฝ๏ฟฝ๏ฟฝ๐จ๐๐ข๐ง๐ ๐ข๐ง ๐ญ๐ก๐ ๐๐ฎ๐๐ข๐ญ๐จ๐ซ๐ฒ ๐๐๐ง๐ญ๐ซ๐๐ฅ ๐ฉ๐ซ๐จ๐๐๐ฌ๐ฌ๐ข๐ง๐ ๐ฉ๐๐ญ๐ก๐ฐ๐๐ฒ ๐ฎ๐ฌ๐ข๐ง๐ ๐ญ๐ฐ๐จ-๐ฉ๐ก๐จ๐ญ๐จ๐ง ๐ข๐ฆ๐๐ ๐ข๐ง๐ ๐ข๐ง ๐๐ซ๐๐๐ฅ๐ฒ ๐๐๐ก๐๐ฏ๐ข๐ง๐ ๐ฆ๐ข๐๐."
She showcased how SUPERNOVA-600's ๐๐ฎ๐๐ฅ-๐๐ก๐๐ง๏ฟฝ๏ฟฝ๐๐ฅ ๐๐ฉ๐ฉ๐ซ๐จ๐๐๐ก is helping uncover the neural mechanisms linking sensory inputs and reward processing.
๐ฌ ๐๐๐ง๐จ๐ฌ๐ฒ๐ฆ๐ฉ๐จ๐ฌ๐ข๐ฎ๐ฆ ๐๐ข๐ ๐ก๐ฅ๐ข๐ ๐ก๐ญ
Dr. Runlong Wu presented exciting results on:
โ๐ ๐ฅ๐จ๐ง๐ -๐ฐ๐จ๐ซ๐ค๐ข๐ง๐ ๐๐ข๐ฌ๐ญ๐๐ง๐๐ ๐ฆ๐ข๐ง๐ข๐๐ญ๐ฎ๐ซ๐ ๐ญ๐ฐ๐จ-๐ฉ๐ก๐จ๐ญ๐จ๐ง ๐ฆ๐ข๐๐ซ๐จ๐ฌ๐๐จ๐ฉ๐ ๐๐ง๐๐๐ฅ๐๐ฌ ๐๐ซ๐จ๐ฌ๐ฌ-๐ฌ๐ฉ๐๐๐ข๐๐ฌ ๐ข๐ฆ๐๐ ๐ข๐ง๐ ๐๐ซ๐จ๐ฆ ๐ซ๐จ๐๐๐ง๐ญ๐ฌ ๐ญ๐จ ๐ง๐จ๐ง๐ก๐ฎ๐ฆ๐๐ง ๐ฉ๐ซ๐ข๐ฆ๐๐ญ๐๐ฌ.โ
A powerful demonstration of how miniature multiphoton imaging is expanding into ๐ง๐จ๐ง๐ก๐ฎ๐ฆ๐๐ง ๐ฉ๐ซ๐ข๐ฆ๐๐ญ๐๐ฌ.
๐ Tomorrow is the final day of SfN 2025!
If you haven't visited yet โ or if you want to dive deeper into our technologies โ come see us at Booth #913.
Let's make the last day count!
#SfN2025 #Neuroscience #TwoPhotonImaging #Mini2P #InVivoImaging #FreelyMovingAnimals #BrainImaging