Ahmed Abdelbaki

Research scientist @TheCrick @NiakanLab Cell fate decisions in human embryos.

[Nature Biotechnology @NatureBiotech]

Live imaging of late-stage preimplantation human embryos reveals de novo mitotic errors https://t.co/IiMn4WS9kc

[Ahmed Abdelbaki @Abdelbaky47]

@BailWeatherbee Congratulations 🙌 well deserved 🌺

[Ahmed Abdelbaki @Abdelbaky47]

@ASBrumm @Dev_Cell Congratulations 🥳 Sophie well deserved

[Ahmed Abdelbaki @Abdelbaky47]

special thank you to Kathy and my colleagues and all collaborators for their support in imaging early human embryos!!
@NiakanLab

[Ahmed Abdelbaki @Abdelbaky47]

Pleased to share my latest work, "Live imaging human embryos reveals mitotic errors and lineage restriction prior to implantation." We used live imaging to uncover key insights into mitotic errors and lineage specification just before implantation.
https://t.co/Hjks1H824w

[Ahmed Abdelbaki @Abdelbaky47]

9/ Overall, we established that mitotic chromosome segregation errors arise just before implantation, contributing to aneuploidy mosaicism. These findings are vital to understanding the events that affect implantation success.

[Ahmed Abdelbaki @Abdelbaky47]

6/We found the majority of lagging chromosomes were passively inherited by one daughter cell, instead of reincorporating into the nuclei, suggesting a distinct pattern of micronuclei inheritance in human embryos.

[Ahmed Abdelbaki @Abdelbaky47]

5/ Interestingly, we found that human blastocysts exhibited a number of chromosome missegregation events including multipolar division, lagging chromosomes, misalignment and mitotic slippage at the blastocyst stage.

[Ahmed Abdelbaki @Abdelbaky47]

7/By semi-automated segmentation, we tracked the position of labelled cells in human embryos and observed that while most labelled cells remained segregated to the outside, and therefore restricted to a placental-progenitor fate.

[Ahmed Abdelbaki @Abdelbaky47]

@MLAgerholm_ @LabBrickman @reNEW_Global @josh_brickman @CellCellPress Congratulations madeleine🎉🎉 great work 🎉🎉

[Ahmed Abdelbaki @Abdelbaky47]

@millieerace Congratulations 🥳