ADAPT-Sepsis

Biomarker-guided duration of antibiotic treatment for sepsis

[NCA Research NHS @NCAresearchNHS]

A simple blood test can tell doctors when it is safe to stop antibiotics in patients recovering from #sepsis, a review has found. The work supported by @NCAlliance_NHS & other GM organisations & co-authored by @darknatter is published in @Anaes_Journal
https://t.co/t68N6QMN2U

[ADAPT-Sepsis @AdaptSepsis]

Cost effectiveness of PCT-guided antibiotic discontinuation explored https://t.co/zW4vYAfKf3

[UKCCRG @UKCCRGroup]

Primary outcome ⁦@UKCCRGroup⁩ ⁦@AdaptSepsis⁩ . Safe reduction in antibiotics ⁦@DarkNatter⁩ #UKCCRF25

[UKCCRG @UKCCRGroup]

⁦@DarkNatter⁩ presents ⁦@AdaptSepsis⁩ #UKCCRF25 lovely presentation

[ADAPT-Sepsis @AdaptSepsis]

Delighted to have the chance to address important international discussions about @AdaptSepsis https://t.co/V8QZgqgbxv

[JAMA @JAMA_current]

Editor’s choice from the February 25 issue.

➡️ Camrelizumab With Chemotherapy in Patients With Early or Locally Advanced TNBC
➡️ Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis
➡️ Essential Thrombocythemia: A Review; and more.

https://t.co/kRpTEJttDt

#JAMA #MedicalResearch #ClinicalTrials

[Paul Dark @DarkNatter]

@WICSBottomLine @hqva Thank you for this detailed review and comments. We @AdaptSepsis are working on trial process evaluation and health economic outcomes right now, so more to come to aid understanding of results. Hopefully, we will see you all @ICS_updates events in 2025 for further discussions

[ADAPT-Sepsis @AdaptSepsis]

@CarrolEnitan @LancetChildAdol Congratulations on delivering and reporting an important study 👏 👏 👏. Looking forward to more discussions together and with @Pronto_Trial soon. @NIHRresearch @DarkNatter @[email protected]

[Enitan Carrol 🇬🇲🇸🇱🏴󠁧󠁢󠁳󠁣󠁴󠁿🇬🇧 @CarrolEnitan]

1/ Delighted to report the results of the Procalcitonin-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection in the UK (BATCH) trial in @LancetChildAdol https://t.co/FI5mzk3A7j

[The University of Manchester News @UoMNews]

A major UK patient trial of a new biomarker testing protocol for sepsis, led by @OfficialUoM researchers, has shown it is possible to safely stop antibiotic treatment earlier than current care 🔬

@FBMH_UoM @DarkNatter

Read more about the trial 👇
https://t.co/0w0WKwcivz

[Critical Care Reviews @CritCareReviews]

@darknatter presents the results of the @AdaptSepsis trial results earlier today at @CCRdownunder

The paper has been published in @JAMA_current
https://t.co/BK8lAqLFXd

[Critical Care Reviews @CritCareReviews]

Chief Investigator @darknatter shares the findings from the #ADAPTsepsistrial at #CCRdownunder

@adaptsepsis @FBMH_UoM @NIHRresearch @EPPiC_Warwick @NCAresearchNHS @JAMA_current

[Oldham ICU @OldhamICU]

We are delighted to have contributed to this important trial. Because clinical research is how we improve the care we deliver. Thank you to our patients who took part. @AdaptSepsis @NCAresearchNHS @DarkNatter

[Keith Couper @KeithCouper]

Fantastic work led by @darknatter and delivered by the phenomenal UK Critical Care community.

We can safely reduce antibiotic duration using procalcitonin (but not CRP).

@AdaptSepsis @WarwickCTU

[Critical Care Reviews @CritCareReviews]

We're delighted to announce @AdaptSepsis as our first trial result presentation at #CCRdownunder

ADAPT-Sepsis is a 2760 patient RCT investigating biomarker-guided duration of antibiotic therapy in patients with sepsis

To be presented by @DarkNatter

https://t.co/b4KzFpBA2r

[Critical Care Reviews @CritCareReviews]

From Belfast to Melbourne - CCR Down Under is coming

The Best Critical Care Trials in the World

#CCRdownunder
https://t.co/VXLd1WDL9H

@intensiveblog @precordialthump @KBibbinsDomingo @giovannilandoni @GiacomoMonti @BaiardoMartina @anzicsctg @chodgsonANZICRC @DogICUma

[CEDAR @CEDAR_Cardiff]

Thrilled to hear that the @AdaptSepsis team have reached their recruitment target - well done everyone!
We're looking forward to comparing our process evaluation findings with your trial results in the coming months! https://t.co/k8azAAe0ZK

[Ingeborg Welters @IngeborgWelters]

@DarkNatter @AdaptSepsis @NCAresearchNHS @WCTU @FBMH_UoM Congratulations, Paul, looking forward to the results!

[Oldham ICU @OldhamICU]

Great work to all involved in completing recruitment to the @AdaptSepsis study. Thank you to our research team for their hard work in recruiting 85 of the number below! @NCAresearchNHS @OldhamCO_NHS

[Emma Boxall @Littleem10]

@DarkNatter @AdaptSepsis @NCAresearchNHS @WCTU @FBMH_UoM Amazing!! Well done xx