Aitor Martinez

#Mitochondria #ubiquitin and #mitophagy lover🔬⚗️🤩 Investigating Neurodegenerative Diseases Postdoctoral fellow at @whitworth_lab @MRC_MBU

[Aitor Martinez @Aitor_Mtz]

So happy that our new paper is finally out!🥳 Thank you everyone is his couldn't have been done without your help and support🫶🏼

[Molecular Neurodegeneration @MolNeuro]

'#Mitochondrial CISD1/Cisd accumulation blocks #mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in #Pink1/#parkin models'

@Aitor_Mtz @alsanchezmar Jake Pickering...@whitworth_lab @MRC_MBU #Parkinsons

https://t.co/hPfdOveW2n

[ChiefraT @ChiefraFba]

Another perfect short zone 🤝

[PrudentLab @LabPrudent]

Job Alert!
Our lab is recruiting a Postdoctoral fellow to work on the interplay between mitochondrial morphology, mb contact sites, mtDNA dynamics and quality control.
Have a look if interested! @MRC_MBU @Cambridge_Uni

https://t.co/sJ0lINsD4G

[Luis Carlos Tábara Rodríguez @Tabara_LC]

Thrilled to announce that our project has been published in @CellCellPress. In this work, we link mitochondrial dynamics to mitochondrial quality control and mtDNA maintenance by characterizing the molecular function of MTFP1. Please DM; happy to discuss! https://t.co/uZqi9Fc8PM

[David Pla-Martín @Dpla_]

A must read for mito aficionados https://t.co/LOn0rSqrjV

[David Pla-Martín @Dpla_]

Second must read of the day! One of my favorite topics, mtDNA and innate immunity!
https://t.co/oRPIk8x9PN

[S @SsJankauskas]

Redistribution of mitochondrial protein genes from mtDNA to nucleus early in evolution put a hard challenge for nervous system much later. Neurons need somehow to supply mito in axon terminals with proteins. And transport of substances through a long axons could take days - a period longer than lifetime of many proteins. And especially longer than lifetime of “consumables” proteins like PINK1 that are intended to be degraded very quickly. And without PINK1 the mitochondria quality control mechanism is vanished with all detrimental consequences you can imagine.

In a set of mind blowing works @HarbauerL demonstrated that this problem is solved by co-transporting mitochondria together with mRNAs of short lived proteins they need. Mitochondrion travels through axon carrying mRNA that it will use for protein synthesis later 🤯🤯🤯

I really recommend to read their papers as they deciphered many details of this machinery. I will only mention that Insulin dependent inactivation of AMPK disrupts above mentioned mechanism, potentially linking insulin resistance with neurodegeneration. However, it requires further research cause IR is associated with not only increased levels of circulating insulin, but also with some degree of InsR signaling attenuation.

https://t.co/391TyFxj3V

https://t.co/2mgaTFxkdB

[Natalie Porat-Shliom @PoratShliomLab]

Did you know that hepatocytes, located 300 microns apart, have different mitochondria? Learn how we use advanced microscopy to study mitochondrial physiology in vivo. Sunday 8:45 am Conv. Ctr., 102 #APS2024 #liverzonation #mitochondria

[Martin Picard @MitoPsychoBio]

Today marks the transition from data collection to data analysis for our Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study.

Six years of work by dozens of people across countries—thank you! So much to learn.

https://t.co/K54pfxZr1H

[Martin Picard @MitoPsychoBio]

Mitochondria as Cellular and Organismal Signaling Hubs

"They are vital in cellular and organismal pathways that direct metabolism, stress responses, immunity, and cellular fate."

https://t.co/wSj0CNfaBq

[Jean-Francois Trempe @jftrempe]

We just published our investigation on PINK1 inhibitors; PRT062607, a SYK inhibitor, also inhibits PINK1 (IC50 1 uM). The inhibitor is not selective for PINK1, but paves the way to the development of PINK1 selective chemical probes: https://t.co/tgrSOoiMlz

[BrentRyanLab @BRyanLab2]

Our new review exploring how CRISPRi can and will be used in iPSC models to understand neurodegeneration is available now in Biochemical Society Transactions https://t.co/uN3dOAuEcT

[Aitor Martinez @Aitor_Mtz]

@J_pickering01 @IRBBarcelona @MSCActions @MitoTherapx_Lab @avlecvie Congrats Jake and good luck in your new avenues!

[Rapé Lab @RapeLab]

Excited to announce the Molecular Therapeutics Initiative @UCBerkeley, which in the age of #InducedProximity will turn exciting biology into new therapeutic modalities for patients in need. Thank you to our generous donor, who made this possible!

https://t.co/izDfArlcJu

[Jonny Nixon-Abell @AbellJonny]

🚨 JOB CALL!!! 🚨

If you’re interested in neuronal cell biology, come and work with us to use custom imaging and omics tools to study organelle contact sites in neurons.

Please RT friends‼️

Open calls for a @wellcometrust funded Post doc and RA position listed below…

[Ralser Lab @RalserLab]

Did you know that 28 out of 34 signalling pathways, and ~60% of the proteome, respond differently depending on the metal ion environment? Neither did we, but now believe that the metal ion levels are one of the big "known unknowns" in cellular networks https://t.co/lqTsBY2mBt

[Jean-Francois Trempe @jftrempe]

Our article on PINK1 forming a complex with TOM and TIM23 is out today. Congrats Mohamed and Andrew! Great collaboration with the Fon lab. https://t.co/hbGG2zd2D3

[Aitor Martinez @Aitor_Mtz]

Best place do a PhD in mitochondrial biology in the world! If you want to cure Neurodegenerative diseases and study mitophagy (also Ca2+) @whitworth_lab is the best. Im not biased at all😜

[MRC MBU @MRC_MBU]

UKRI/MRC PhD studentships available for UK/Irish citizens or UK permanent residents for entry in October 2024. Closing date 14 March. Possible projects below.
To apply see: https://t.co/qPhEtjmu4d
@whitworth_lab @LabPrudent @mito_gene

[MRC MBU @MRC_MBU]

UKRI/MRC PhD studentships available for UK/Irish citizens or UK permanent residents for entry in October 2024. Closing date 14 March. Possible projects below.
To apply see: https://t.co/qPhEtjmu4d
@whitworth_lab @LabPrudent @mito_gene

[Verena Kohler @_VerenaKohler]

Translation is an emerging constraint on protein homeostasis in ageing https://t.co/8s45UyXorE

[Aitor Martinez @Aitor_Mtz]

New mitophagy BiomedNews issue to keep you updated!

Highlights:

Highthroughput proteomic assay for Parkin activators

Inner mitochondrial membrane exposure triggers apoptotic mitophagy

https://t.co/i519LF09bw