Alex Clark

Postdoctoral fellow in the Saucerman Lab at UVA studying cardiac development and electrophysiology

[Alex Clark @AlexClark111]

https://t.co/gf6qqGTZCS

[Alex Clark @AlexClark111]

Excited to share the last two publications from my PhD! We explore and discuss iPSC-CM EPhys heterogeneity in manual and automated patch studies, with an eye towards experimental design and safety pharmacology.
https://t.co/gf6qqGTZCS
https://t.co/krj6qMCfWd

[Jeff Saucerman @jsauce7]

Come join @sauce_lab to discover drugs for heart failure and regeneration with systems biology! Postdocs @UVACVRC open and free no-GRE PhD app due 12/15 @UVABME.

[Europace Editor-in-Chief @EuropaceEiC]

New tools for translational cardiac electrophysiology

👉Leak currents and induced pluripotent stem cell-derived cardiomyocytes

Now #EUROPACE_FRESH_OFF_THE_PRESS
📖https://t.co/aTH5L0V8kh

@GiulioConte9 @Dominik_Linz @FraSantoroMD
@AndyZhangMD @marcovitoloMD

[European Society of Cardiology Journals @ESC_Journals]

Leak currents and induced pluripotent stem cell-derived cardiomyocytes in translational cardiac electrophysiology 👉 https://t.co/h6ZSsBbNUP

@EuropaceEiC @GiulioConte9 @Dominik_Linz @FraSantoroMD @AndyZhangMD @marcovitoloMD #hiPSC #Europace #arrhythmias #translational

[Alex Clark @AlexClark111]

Excited to share the latest from the @DavidChristini lab. This work was completed with Michael Clerx, Siyu Wei, @ChonLokLei , @teunpdeboer, @GaryMirams, and Trine Krogh-Madsen.
https://t.co/BhJzUkZm0l

We're very appreciated of the accompanying commentary.
https://t.co/En9Gm97rsD

[Alex Clark @AlexClark111]

Dissertation defense scheduled for Tuesday, April 4 at 12 EDT. DM me for a Zoom link!

I'll be discussing:
My PhD journey
Arrhythmia mechanisms
Preclinical drug screening
iPSC-CM electrophysiology/heterogeneity
Cell-specific modeling
Manual and automated patch-clamp techniques

[Alex Clark @AlexClark111]

Finally, this paper was made possible by the contributions and expertise of my advisers (Trine Krogh-Madsen and @DavidChristini) and our terrific co-authors: @MichaelClerx, Siyu Wei, @ChonLokLei, @teunpdeboer, and @GaryMirams.

We welcome your feedback and questions!

[Alex Clark @AlexClark111]

Excited to share our new preprint! We investigate the effects of patch-clamp seal-leak current on iPSC-CM action potential morphology.

See thread for more details!

https://t.co/xXlw2JjE7N

[Alex Clark @AlexClark111]

Based on these findings, we make three recommendations that should be considered when interpreting, analysing and fitting iPSC-CM action potential data.

[Alex Clark @AlexClark111]

I'll be discussing these findings and some new results during a @NanionTech webinar this Thursday at 10AM EDT. Register here: https://t.co/2xG0pl46of

[Alex Clark @AlexClark111]

Excited to share my first accepted paper with the @DavidChristini Lab. We developed a pipeline for detecting drug cardiotoxicity using electrophysiological modeling and iPSC-CMs. 

https://t.co/jT7bcG8b3r