Alex Keeble

Muscle biologist

[Eric Topol @EricTopol]

Big progress vs cancer, folks.
The kind of event curves from randomized trials that we've not seen before for a couple of the most deadly cancers. Congrats to the oncology research community for getting these trial done. #ASCO26, @ASCO

[NBA @NBA]

LEBRON DELIVERED IN THE SERIES-CLINCHING WIN!

👑 28 PTS
👑 7 REB
👑 8 AST

Lakers will face the Thunder in Round 2 of the NBA Playoffs presented by @Google 🍿

[Eric Topol @EricTopol]

No less, enabling the design de novo proteins, a brilliant review @nature
"Over the next five to ten years, we anticipate the design of sophisticated protein nanomachines and materials with functionality ranging far beyond that generated during natural evolution for a wide range of
applications in medicine, technology and sustainability,"

https://t.co/PKyvvHey2t

[Christopher Fry @ChrisFryPhD]

Back-to-back papers from @AlexKeeble5 and @saragonzalezve . Working with @MVFranchi , we show that limb suspension and post-ACLR muscle exhibit fundamentally different muscle transcriptomic signatures.
https://t.co/MO2RVfPrVx

[Christopher Fry @ChrisFryPhD]

Excited to share our findings on sex differences in muscle signaling after ACL reconstruction—females exhibit a markedly divergent transcriptomic response, with greater susceptibility to atrophy, oxidative stress, and impaired angiogenic signaling:
https://t.co/THIZVOy8en

[Craig A. Goodman @CraigAGoodman1]

Treating age-related loss of muscle mass and function: Where should we be focusing?
https://t.co/UyY5aZqZFr

[Abigail Mackey @AbigailMackey1]

We wrote this letter to address the overly rigid preregistration requirements imposed now by many journals on exploratory experimental physiology research - time to align guidelines with contemporary research methods!

@proferikrichter
@ISMCopenhagen

https://t.co/MzG7VZ058H

[The Hornberger Lab @HornbergerLab]

1/ Why do muscles atrophy with aging and disuse?

Is it because each tiny little myofibril gets smaller… or is it because we lose myofibrils?

In our new study, we addressed this in humans and mice. https://t.co/J7nEk1r6P2

Full breakdown of the findings in this thread 👇

[Prof. Carl Sagan @ProfCarlSagan]

In 1990, as Voyager 1 was leaving the solar system, Sagan fought a long internal battle at NASA to turn the cameras around one last time to photograph Earth. Many engineers opposed it, fearing it might damage the cameras or waste time.

But Sagan’s successful effort resulted in the "Pale Blue Dot" image. He used this tiny, 0.12-pixel speck of Earth to write his famous reflection on how "every human being who ever was" lived on that "mote of dust suspended in a sunbeam".

[Christopher Fry @ChrisFryPhD]

Congrats to @AlexKeeble5 for his manuscript being selected as Editor’s Choice and making the cover at @JPhysiol for December! https://t.co/zCrbAoScwt

[Alex Keeble @AlexKeeble5]

@ChrisFryPhD @JPhysiol Thanks, Chris!

[Alex Keeble @AlexKeeble5]

@FabioSarto3 @ChrisFryPhD @saragonzalezve Thanks, Fabio!

[Alex Keeble @AlexKeeble5]

Very excited to share some of our recent work studying primary human MPCs from patients with late stage CKD! We identify metallothionein-induced zinc deficiency as a contributor to attenuated myogenesis in this population.
@ChrisFryPhD @saragonzalezve

https://t.co/udQfULI7iV

[Kevin Murach @KevinMurachPhD]

Upcoming Postdoc Position! With Chris Nelson’s lab at U of A, we are looking for a fully supported 2-year postdoc to work on muscle gene editing and detection of gene doping in vivo. If interested, email myself and Chris: [email protected] and [email protected] #myotwitter

[Kevin Murach @KevinMurachPhD]

A heavy lift from a literal strongman, PhD candidate @PJKoopmans “The Age-Dependent Resident Myonuclear Multi-Omic Response to a Skeletal Muscle Hypertrophic Stimulus” 💪🏻 https://t.co/MfwqNOcNzb

[Christopher Fry @ChrisFryPhD]

BIG congrats to @saragonzalezve for passing her quals today - welcome to PhD candidacy! A much deserved celebration @UKYCMB

[The Hornberger Lab @HornbergerLab]

9/ Shoutout to co-first authors @jhibbert_phd and @kentjorgenson_ and the rest of the team pushing this 8-year-long project to the finish line. The next step is to get it published. Please give it a repost if you think it will be impactful for the field. https://t.co/WqkBT4Cvwj

[Lammerding Lab @LammerdingLab]

Interested in #mechanobiology of the cell nucleus? The submission deadline for the FASEB Science Research Conference on the Mechanobiology of the Nucleus is August 31, 2025. Submit your abstract to be considered for a platform presentation.
#MBNSRC
https://t.co/jLVJ3vtN7x

[Kevin Murach @KevinMurachPhD]

“Satellite cells choreograph an immune cell-fibrogenic cell circuit during mechanical loading in geriatric skeletal muscle” by @NickTThomas w/@ChrisFryPhD @UKYCMB #myotwitter @PNASNexus Nicely done by Nicky T!!! @UArkResearch @uacoehp https://t.co/5kFyplxqhE

[The Nobel Prize @NobelPrize]

Edwin Krebs and Edmond Fischer showed how proteins in the muscle cell make the energy supply accessible for muscular work and how the breakdown of glycogen to glucose is controlled in the skeletal muscles.

Read more: https://t.co/NPTwgFGZZJ

#NobelPrize