Alex Wei

UPenn Neuroscience PhD. CRISPR. DNA Methylation. NHGRI F31 Fellow. UCSB Alumnus. Powerlifter. Brazilian Jiu Jitsu. 70% Coffee. 🌴🌊🌞

[bioRxiv Genomics @biorxiv_genomic]

De-novo DNA Methylation of Bivalent Promoters Induces Gene Activation through PRC2 Displacement https://t.co/lYA2MsYk8S #biorxiv_genomic

[Jamie Hackett @hackettlab]

How do chromatin modifications quantitatively impact gene expression?

How do sequence variants or combinatorial marks influence relationships?

We developed a modular #EpigenomeEditing toolkit to systematically test these Q, published today 🧵…

https://t.co/2p4W0J50Oc

[Patrick Hsu @pdhsu]

Just shared at @KeystoneSymp a new @ArcInstitute discovery of the bridge RNA recombinase mechanism: a new class of natural RNA-guided systems that retains the key property of programmability from RNAi and CRISPR while enabling large-scale genome design beyond RNA and DNA cuts

[Maxim Greenberg @maxvcg]

🚨New Preprint🚨 In this study, we set out to determine how the de novo DNA methylation program impacts the 3D cis regulatory landscape. Comments welcome! Here's a thread detailing our study's key findings (1/12) https://t.co/UHElRVJTzC

[Tong Wang @twang0518]

Excited to share our paper out today in @nchembio! DM-Seq is our non-destructive approach for detecting DNA methylation. We even benchmarked against the recently acquired diagnostic technology TAPS (by Exact, maker of Cologuard). Thread! 🧵https://t.co/0wNnP7NdAw

[Alex Wei @AlexTWei]

Check out this Review I wrote with @hao_wu_7 on recent advances in mammalian DNA methylation dynamics, and emergent technologies in the field that afford unprecedented mechanistic dissection! 🧬

[Development @Dev_journal]

Mammalian DNA methylome dynamics: mechanisms, functions and new frontiers

In their Review, @AlexTWei & @hao_wu_7 examine how DNA methylation dynamics contribute to mammalian development and tissue maturation, highlighting recent technological advances.

https://t.co/ZZnllurDeK

[Hao Wu | 吴昊 @hao_wu_7]

Led by talented graduate student @AlexTWei in the lab, we review the recent advances in the study of mammalian DNA methylome dynamics.

[Penn NGG @PennNGG]

NGG is proud to present the upcoming Thesis Defense of Alex Wei (@AlexTWei) of the Wu Lab! Please join us in-person or virtually (DM us for the link!) on Friday, December 9th. Best of luck, Alex! #WeAreNGG #AlmostPhDone

[Schübeler Lab @SchubelerLab]

CG rich regulatory regions in our genomes are efficiently repressed by DNA methylation, but how? New work from the lab, now online @ Nature Genetics (https://t.co/t3Scw58xTK), suggests that direct inhibition of transcription factor binding is a prevailing mode of action 1/7

[Junwei Shi @junwei_s]

Dear Twitter friends and please RT: Kohli lab and our lab are seeking a joint research technician. Great opportunity to work on our collaborative projects on new CRISPR gene editing toolkits. Here is the job post link: https://t.co/s68ImlWMUG

[Alexandra Mattei @AL_Mattei]

What does DNA methylation do again? Our answer in 32 short pages. Excited to finally get to share a true labor of love Nina Bailly and I worked on together throughout the pandemic, a swan song to my PhD and time in Germany. https://t.co/2PrbMim23e

[Hao Wu | 吴昊 @hao_wu_7]

Come work with us to lead new single-cell & functional genomics projects. More info here: https://t.co/LqCV6PNgB7

[Hao Wu | 吴昊 @hao_wu_7]

Happy to announce our new project funded by the IGVF consortium & @genome_gov. I am fortunate to collaborate with colleagues at @PennMedicine (@UPenn_SongMing, @SarahTishkoff, @kiranmusunuru @junwei_s, @ziyue_gao, Wenli Yang) & @UW (Sreeram Kannan). 1/2

[Patrick Hsu @pdhsu]

Tour de force engineering @Nature by @jgooten @omarabudayyeh discovering Cas7-11 as a collateral-free RNA targeting tool. Also a beautiful story of CRISPR evolutionary biology blurring the lines of multi-subunit and single effector defense systems

https://t.co/Mr1LoZ3Mwy

[Feng Zhang @zhangf]

CRISPR systems are quite diverse, including some, like CRISPR-Cas13, which target RNA. @soumya_kannan12 & @altaetran found tiny versions of Cas13b (Cas13bt) that can be used to create RNA editors small enough to fit into a single AAV for in vivo delivery. https://t.co/dvnC8l29uY

[Tong Wang @twang0518]

We wrote about how four classes of *enzymes* can be applied for BS-free sequencing of 5mC and 5hmC. Check it out here in @MolMetab! https://t.co/k9Upl83IbF

[Hao Wu | 吴昊 @hao_wu_7]

Excited to be part of this global effort. Look forward to contributing to a better understanding of pediatric development of human immune system together with our amazing colleagues at @CHOP_Research and @PennGenetics.

[Junwei Shi @junwei_s]

Please RT: Shi Lab is seeking a research technician. Great opportunity to work on exciting projects ranging from developing gene editing technology to applying the CRISPR toolbox to investigate cancer dependencies.If interest, DM or email me jushi#upenn.edu.

[Hao Wu | 吴昊 @hao_wu_7]

Preprint alert! By harnessing differential activity of a DNA deaminase towards 5mC and chemically protected 5hmC, we can teach an old dog like bisulfite sequencing a new trick: quantitative 5hmC sequencing in single cells. https://t.co/8iCFZAKdzv

[Maxim Greenberg @maxvcg]

🚨 First Greenberg Lab publication 🚨 There were some very cool papers from last year that I wanted to incorporate into our broader understanding of DNA methylation reprogramming in vivo (with a dash of speculation about why this all evolved) https://t.co/ibHOGJapNN