Alex Detappe

husband, father, medical physicist and nano-scientist, innovator and entrepreneur. opinions are my own

[Eric Topol @EricTopol]

A very impressive study for how we could prevent lung cancer more than 5 years before it is diagnosed. Using machine learning, discovery of a 14-plasma protein signature of risk that predicts responsiveness to an antibody therapy to interleukin, IL-1β
Validated across 8 cohorts
@CellCellPress @CharlesSwanton
https://t.co/qpPtgs1dH0

[Alex Detappe @AlxDetappe]

Link here: https://t.co/oZRK3kyPDm

[Alex Detappe @AlxDetappe]

New preprint on bioRxiv: Hydrogel confinement enables subcutaneous delivery of vesicant antibody-drug conjugates.
We observe that:

[Alex Detappe @AlxDetappe]

• Platform generalization across T-DM1, T-DXd, trastuzumab and enfortumab vedotin establishes that the determining variable is payload pharmacology rather than target or conjugate chemistry.

[Alex Detappe @AlxDetappe]

ADC are IV-dominant. Biology permits SC. Engineering blocks it. Our J Controlled Release perspective details what's needed: conjugation chemistry, high-conc formulations (>100 mg/mL), biomaterials, devices.
https://t.co/fU79qLroSP

@ERC_Research @laliguecancer @GustaveRoussy

[Alex Detappe @AlxDetappe]

Thanks a lot for inviting me! It was a blast meeting you all!

[CIPF @CIPFciencia]

Amazing A. Detappe! Liposomal nanoformulations, ultrasmall gadolinium-based nanoparticles & polymer-nanoparticle hydrogel are being developed to enable at-home administration of hospital-restricted biologics. Efforts to shorten the path from bench chemistry to patient benefit.

[Alex Detappe @AlxDetappe]

@julnicolas @CNRSIdFSud @CNRS @CNRSchimie @UnivParisSaclay @umr8612 @ERC_Research @Pharma_UPSaclay Love it! Congrats !

[Nature Reviews Bioengineering @natrevbioeng]

Dynamic precision cancer nanomedicine https://t.co/mDLyk4HAN1

[Alex Detappe @AlxDetappe]

New in @NatRevBioeng w/ @FAndreMD
: No targeted nanomedicines approved despite preclinical tumor accumulation. Our thesis: It's not poor delivery, it's static formulations in a dynamic disease. Time to test adaptive nanomedicine. Thanks
@ChristineHorejs!
https://t.co/5oUw0dlfwT

[Alex Detappe @AlxDetappe]

@laliguecancer @ERC_Research @unistra @CGFL_Dijon #InstitutMedicamentStrasbourg #ICANS

[Alex Detappe @AlxDetappe]

Our latest paper in @ACSNano is out! 🤩
We built tiny peptide-based “delivery vehicles” that bring heavy metals (Gd, Bi, Hf) to tumors so we can fairly compare how well each one boosts external radiotherapy and radioligand therapies.

[Alex Detappe @AlxDetappe]

Big congrats to Dr. Sebastian and our amazing collaborators for making this happen 🙌
If you’re interested in smarter radioenhancers and “see & treat” oncology, check out the paper:
🔗 https://t.co/AkISNvLZvz

[Alex Detappe @AlxDetappe]

@rvdmnanomeds @EUeic @WillemNANO @BioTRIPBV @AMakriPistikou @twan_lammers @radboudumc @TUeindhoven1 @VUBrussel @RWTH Congrats!! this is huge! Well done!

[Alex Detappe @AlxDetappe]

@julnicolas J'ai des bureaux et paillasses dispos pas trop loin si tu veux re localiser 😇

[Alex Detappe @AlxDetappe]

Thank you @le_Parisien @leparisien_94 for being with us at @GustaveRoussy on this special day. It’s not just about a new building, but about pushing research forward and giving more hope to patients.

[Le Parisien | 94 @leparisien_94]

« Les patients attendent beaucoup de nous » : face au cancer, Gustave-Roussy offre un écrin tout neuf à ses chercheurs https://t.co/NvT7rgOZaf

[Gustave Roussy @GustaveRoussy]

📰 « Les patients attendent beaucoup de nous » : face au cancer, @GustaveRoussy offre un écrin tout neuf à ses chercheurs.

Les Prs Fabrice @barlesi et @FAndreMD rappellent l’ambition de l’institut dans @le_Parisien ⤵
https://t.co/tvsmxM1Enb