(36/??) Grace awakens strapped down to a gurney, completely strapped down. She has an IV drip inserted into her, and has bandaged underneath her shirt with blood around her chest. She yells for help, asking herself what is this, confused & scared.
We'll not get too much further
(30/??) Grace understandably seems taken aback, while Nathan says that Alyssa died "eight years ago". As this game will most likely take place in 2026, that puts Alyssa's murder in 2018.
We see some more shots of Alyssa in the Hotel.
My DEEP suspicion is similar to RE7,