CBATL_Analytics

A “think tank” improving transplant care by asking the “right” questions. Using machine learning, big data, and data science to find the best answers.

[Alexandra Shingina, M.D., M.Sc. @AShinginaMD]

The application of machine learning algorithms is limitless! 🦾💻🤖

Check out this cool paper on using MLA to predict GVHD in patients undergoing liver transplantation! @Scott_Biggins @UW @AshleySpannMD

[Liver Transplantation Journal (LTxJournal) @LTxJournal]

Acute graft-vs-host disease following liver #transplantation-Predicting this rare complication using machine learning

A practical model that can identify patients at high risk for GVHD & may warrant additional monitoring w/ peripheral🩸chimerism testing

https://t.co/g9johwgB1V

[CBATL_Analytics @AnalyticsCbatl]

Cooper et al. with CBATL at UWMC developed a machine learning approach to predict recipients at high risk for developing GVHD on factors at the time of OLT. Liver Transpl. 2021 Sep 29.doi: 10.1002/lt.26318. GVHD calculator: https://t.co/G6dpDjJCvI @AnalyticsCbatl #machinelearning

[CBATL_Analytics @AnalyticsCbatl]

@LTxJournal Less than 1% of donor livers between the age of 18-30 need to be split to transplant all pediatric candidates. All adult programs need to establish connections with a pediatric center for splitting and this would result in transplanting their small stature candidates.

[CBATL_Analytics @AnalyticsCbatl]

Donor–Recipient BSA Matching Is Prognostically Significant... : Transplantation Direct https://t.co/RNGjL9l1me

[CBATL_Analytics @AnalyticsCbatl]

Livers From Pediatric Donation After Circulatory Death Donors Represent a Viable and Underutilized Source of Allograft https://t.co/a0qGjKMZEP

[CBATL_Analytics @AnalyticsCbatl]

Donor CMV Reactivation as a Novel Risk Factor for CMV... : Transplantation Direct https://t.co/quPmschdvL

[CBATL_Analytics @AnalyticsCbatl]

Livers From Pediatric Donation After Circulatory Death Donors Represent a Viable and Underutilized Source of Allogr… https://t.co/JLuhH92bjC

[CBATL_Analytics @AnalyticsCbatl]

Association of Donor and Recipient Cytomegalovirus Serostatus on Graft and Patient Survival in Liver Transplant Rec… https://t.co/I8dyRgYsgU

[CBATL_Analytics @AnalyticsCbatl]

https://t.co/Qn5ZqXJ5oj

[Liver Transplantation Journal (LTxJournal) @LTxJournal]

Results:
⭐️D+R- was independently associated with graft loss (aHR 1.13) ad mortality (aHR 1.13).
⭐️This effect was stable at 1 year and beyond 1 year.

[Liver Transplantation Journal (LTxJournal) @LTxJournal]

Association of donor and recipient cytomegalovirus serostatus on graft and patient survival in liver transplant recipients by @PhilipVutien, @HannahImlay, @Scottbiggins4 et al. https://t.co/DvwwJPzRCp

[CBATL_Analytics @AnalyticsCbatl]

More evidence that this practice should become routine.

[SRTR @SRTRNews]

Study finds HCV-positive livers safe for transplantation; Patients cured afterward | https://t.co/MJ1mOGmrzo

#liver #livertransplant #transplantation #transplant

[CBATL_Analytics @AnalyticsCbatl]

Little and CBATL observed pediatric DCD livers are underused but when transplanted have comparable survival to 18-40 year-old DCD donors. This survival is improved when transplanted into pediatric recipients. Pediatric DCD livers are a viable organ source for adults and children.

[CBATL_Analytics @AnalyticsCbatl]

Excellent survival in pediatric recipients undergoing liver transplantation with organs labeled Public Health Service (PHS) high-risk organs was the conclusion of a study by Dick et al. This may lead to increased use of these organs and decreased waitlist mortality. #transplant

[CBATL_Analytics @AnalyticsCbatl]

Butler et al. in a contemporary cohort of deceased donor kidney transplant recipients found no difference in graft loss from DCD compared to DBD grafts. These findings could increase the utilization of DCD kidneys helping to improve the shortage of donor kidneys. #kidney

[ILTS @_ILTS_]

Vanguard Article of the Week: In JAMA Surgery, Locke et al discuss and analyze critical factors contributing to sex-based disparities in liver allocation. https://t.co/dOzzkeMbkp #VanguardArticleoftheWeek #livertransplantation #ILTS

[CBATL_Analytics @AnalyticsCbatl]

Kling and other members of CBATL in follow-up to previous research found there is no difference in 3-year patient and graft survival between kidneys from aviremic HCV donors (HCV Ab+ NAT –) and HCV negative donors (HCV Ab- Nat -). #HCV #kidney #Transplant

[CBATL_Analytics @AnalyticsCbatl]

Kling and other CBATL members observed that the number of donors with hepatitis C virus is increasing. They also observed a concomitant increase in the transplantation of kidneys and livers from aviremic donors. #kidney #liver #transplant #HCV

[CBATL_Analytics @AnalyticsCbatl]

Sibulesky and other CBATL members conducted research supporting the quality of aviremic hepatitis C positive (HCV NAT -) kidneys. Using these kidneys would result in more kidney transplants with the survival being the same as matched controls. #NAT- #Aviremic #kidney #transplant